Current Breast Cancer Reports

, Volume 6, Issue 3, pp 154–158

Molecular Heterogeneity of Triple-Negative Breast Cancer

Translational Research (V Stearns, Section Editor)

DOI: 10.1007/s12609-014-0152-1

Cite this article as:
Abramson, V.G. & Mayer, I.A. Curr Breast Cancer Rep (2014) 6: 154. doi:10.1007/s12609-014-0152-1


Triple-negative breast cancers (TNBCs) are a group of aggressive breast cancers with a greater incidence of relapse, stage-for-stage, than ER/PR-positive and HER2-positive breast cancers, despite optimum loco-regional and systemic therapy. To date, no single targeted therapy has been approved for treatment of TNBC, and cytotoxic chemotherapy remains the standard systemic treatment. Recently, gene expression analysis identified six distinct TNBC subtypes, each with unique biology. In this review we discuss current and forthcoming therapeutic strategies and novel approaches to targeted treatment of these TNBC subtypes.


Triple-negative breast cancer TNBC Gene expression profiles Targeted therapy 

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  1. 1.Division of Hematology/Oncology/ Department of MedicineVanderbilt University School of MedicineNashvilleUSA

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