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Anticholinergic Load and Nutritional Status in Older Individuals

  • Eiji KoseEmail author
  • T. Hirai
  • T. Seki
  • N. Yasuno
Article
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Abstract

Objectives

The association between anticholinergic load-based Anticholinergic Risk Scale scores and nutritional status is unclear in Japanese patients. The aim of this study was to establish whether anticholinergic load affects the nutritional status of geriatric patients in convalescent stages.

Design

Retrospective longitudinal cohort study.

Setting

Convalescent rehabilitation wards.

Participants

Of the 1490 patients aged ≥65 years who were discharged from convalescent rehabilitation wards between July 2010 and October 2018, 908 patients met the eligibility criteria. They were categorized according to the presence or absence of increased anticholinergic load from admission to discharge.

Measurements

Demographic data, laboratory data, the Functional Independence Measure were analyzed between the groups. The primary outcome was Geriatric Nutritional Risk Index (GNRI) at discharge. Multiple linear regression analysis was performed to analyze the relationship between anticholinergic load and GNRI at discharge.

Results

Multiple linear regression analysis after adjusting for confounding factors revealed that anticholinergic load was independently and negatively correlated with GNRI at discharge. Particularly, the use of chlorpromazine, hydroxyzine, haloperidol, metoclopramide, risperidone, etc. increased significantly from admission to discharge.

Conclusion

Increased anticholinergic load during hospitalization may be a predictor of nutritional status in geriatric patients.

Key words

Anticholinergic drug anticholinergic risk scale geriatric nutritional risk index older individuals 

Notes

Acknowledgement

The authors thank the manager of Hitachinaka Gereral Hospital who agreed for this study to take place.

Conflict of interest: The authors declare that there is no conflict of interest regarding the publication of this article.

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Copyright information

© Serdi and Springer-Verlag International SAS, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of PharmacyTeikyo University School of Medicine University HospitalTokyoJapan
  2. 2.Department of PharmacyHitachinaka General HospitalIbarakiJapan
  3. 3.Laboratory of Hospital Pharmacy, School of PharmacyTeikyo UniversityTokyoJapan

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