Advertisement

Association Between Depressive Symptoms and Supplemental Intake of Calcium and Vitamin D in Older Adults

  • M. N. Wu
  • F. He
  • Q. R. Tang
  • J. Chen
  • X. Gu
  • Y. J. Zhai
  • F. D. Li
  • T. Zhang
  • X. Y. Wang
  • Junfen LinEmail author
Article
  • 3 Downloads

Abstract

Objectives

We explored the associations between depressive symptoms and supplemental calcium and vitamin D intake in older adults.

Design

This was a prospective cohort study.

Participants

8,527 older adults aged ≥60 years from Zhejiang Major Public Health Surveillance Program (ZPHS) without depressive symptoms at baseline survey.

Measurements

Participants were divided into non-supplementation, calcium (Ca), vitamin D, and calcium plus vitamin D (CaD) groups based on their supplemental intake during the past year. Depressive symptoms were assessed using the Patient Health Questionnaire-9 (PHQ-9). Binary logistic regression analyses were performed to examine the association between depressive symptoms and supplemental intake.

Results

When compared to the non-supplementation group, the Ca group exhibited a significant odds ratio (OR) of 0.731 (95% CI: 0.552–0.967, P=0.028). After adjusting for age, sex, and Ca food sources, the OR was even smaller for the CaD group (OR: 0.326; 95% CI: 0.119–0.889, P=0.029). Additionally, our results indicated that taking Ca supplements ≥4 days/week yielded a significant OR of 0.690 (95% CI: 0.492–0.968) after full adjustment. Taking CaD supplements ≥4 days/week yielded a significant OR of 0.282 (95% CI: 0.089–0.898) after adjusting for age, sex, and Ca food sources.

Conclusions

Supplemental intake of Ca or CaD ≥4 days/week can decrease the risk of depressive symptoms in older adults, although CaD supplements may be more effective.

Key words

Calcium vitamin D older adults depressive symptoms 

Notes

Acknowledgments

We wish to thank the investigators from 7 selected counties for their investigation and data collection. This work was supported by the Zhejiang Provincial Public Welfare Technology Application Research Project of China (LGF19H260003) and the Zhejiang Provincial Natural Science Foundation of China (LQ19H260001). The financial sponsors played no role in the study design/execution, analysis and interpretation of data, or writing of the manuscript.

Conflicts of interest: None declared.

References

  1. 1.
    Mathers CD, Loncar D. Projections of global mortality and burden of disease from 2002 to 2030. PLoS medicine. 2006;3(11):e442.CrossRefGoogle Scholar
  2. 2.
    Wang F, Zhang QE, Zhang L, et al. Prevalence of major depressive disorder in older adults in China: A systematic review and meta-analysis. Journal of affective disorders. 2018;241:297–304.CrossRefGoogle Scholar
  3. 3.
    Lips P. Worldwide status of vitamin D nutrition. The Journal of steroid biochemistry and molecular biology. 2010;121(1–2):297–300.CrossRefGoogle Scholar
  4. 4.
    Tuyen le D, Hien VT, Binh PT, Yamamoto S. Calcium and Vitamin D Deficiency in Vietnamese: Recommendations for an Intervention Strategy. Journal of nutritional science and vitaminology. 2016;62(1):1–5.CrossRefGoogle Scholar
  5. 5.
    Payne ME, Anderson JJ, Steffens DC. Calcium and vitamin D intakes may be positively associated with brain lesions in depressed and nondepressed elders. Nutrition research. 2008;28(5):285–292.CrossRefGoogle Scholar
  6. 6.
    Steffens DC, Krishnan KR, Crump C, Burke GL. Cerebrovascular disease and evolution of depressive symptoms in the cardiovascular health study. Stroke. 2002;33(6):1636–1644.CrossRefGoogle Scholar
  7. 7.
    Heaney RP, Kopecky S, Maki KC, Hathcock J, Mackay D, Wallace TC. A review of calcium supplements and cardiovascular disease risk. Advances in nutrition. 2012;3(6):763–771.CrossRefGoogle Scholar
  8. 8.
    Demuro A, Mina E, Kayed R, Milton SC, Parker I, Glabe CG. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. The Journal of biological chemistry. 2005;280(17):17294–17300.CrossRefGoogle Scholar
  9. 9.
    Foster TC, Kumar A. Calcium dysregulation in the aging brain. The Neuroscientist: a review journal bringing neurobiology, neurology and psychiatry. 2002;8(4):297–301.CrossRefGoogle Scholar
  10. 10.
    Eyles DW, Smith S, Kinobe R, Hewison M, McGrath JJ. Distribution of the vitamin D receptor and 1 alpha-hydroxylase in human brain. Journal of chemical neuroanatomy. 2005;29(1):21–30.CrossRefGoogle Scholar
  11. 11.
    Yeshokumar AK, Saylor D, Kornberg MD, Mowry EM. Evidence for the Importance of Vitamin D Status in Neurologic Conditions. Current treatment options in neurology. 2015;17(12):51.CrossRefGoogle Scholar
  12. 12.
    Berk M, Sanders KM, Pasco JA, et al. Vitamin D deficiency may play a role in depression. Medical hypotheses. 2007;69(6):1316–1319.CrossRefGoogle Scholar
  13. 13.
    Bae YJ, Kim SK. Low dietary calcium is associated with self-rated depression in middle-aged Korean women. Nutrition research and practice. 2012;6(6):527–533.CrossRefGoogle Scholar
  14. 14.
    Miki T, Kochi T, Eguchi M, et al. Dietary intake of minerals in relation to depressive symptoms in Japanese employees: the Furukawa Nutrition and Health Study. Nutrition. 2015;31(5):686–690.CrossRefGoogle Scholar
  15. 15.
    Bertone-Johnson ER, Powers SI, Spangler L, et al. Vitamin D intake from foods and supplements and depressive symptoms in a diverse population of older women. The American journal of clinical nutrition. 2011;94(4):1104–1112.CrossRefGoogle Scholar
  16. 16.
    Lansdowne AT, Provost SC. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology. 1998;135(4):319–323.CrossRefGoogle Scholar
  17. 17.
    Dumville JC, Miles JN, Porthouse J, Cockayne S, Saxon L, King C. Can vitamin D supplementation prevent winter-time blues? A randomised trial among older women. The journal of nutrition, health & aging. 2006;10(2):151–153.Google Scholar
  18. 18.
    Lin JF, Li FD, Chen XG, et al. Association of postlunch napping duration and night-time sleep duration with cognitive impairment in Chinese elderly: a cross-sectional study. BMJ open. 2018;8(12):e023188.CrossRefGoogle Scholar
  19. 19.
    Chung M, Balk EM, Brendel M, et al. Vitamin D and calcium: a systematic review of health outcomes. Evidence report/technology assessment. 2009(183):1–420.Google Scholar
  20. 20.
    Ghanbari Z, Haghollahi F, Shariat M, Foroshani AR, Ashrafi M. Effects of calcium supplement therapy in women with premenstrual syndrome. Taiwanese journal of obstetrics & gynecology. 2009;48(2):124–129.CrossRefGoogle Scholar
  21. 21.
    Kim TH, Choi JY, Lee HH, Park Y. Associations between Dietary Pattern and Depression in Korean Adolescent Girls. Journal of pediatric and adolescent gynecology. 2015;28(6):533–537.CrossRefGoogle Scholar
  22. 22.
    Bertone-Johnson ER, Powers SI, Spangler L, et al. Vitamin D supplementation and depression in the women’s health initiative calcium and vitamin D trial. American journal of epidemiology. 2012;176(1):1–13.CrossRefGoogle Scholar
  23. 23.
    Jorde R, Sneve M, Figenschau Y, Svartberg J, Waterloo K. Effects of vitamin D supplementation on symptoms of depression in overweight and obese subjects: randomized double blind trial. Journal of internal medicine. 2008;264(6):599–609.CrossRefGoogle Scholar
  24. 24.
    Motsinger S, Lazovich D, MacLehose RF, Torkelson CJ, Robien K. Vitamin D intake and mental health-related quality of life in older women: The Iowa Women’s Health Study. Maturitas. 2012;71(3):267–273.CrossRefGoogle Scholar
  25. 25.
    Sanders KM, Stuart AL, Williamson EJ, et al. Annual high-dose vitamin D3 and mental well-being: randomised controlled trial. The British journal of psychiatry: the journal of mental science. 2011;198(5):357–364.CrossRefGoogle Scholar
  26. 26.
    Kjaergaard M, Waterloo K, Wang CE, et al. Effect of vitamin D supplement on depression scores in people with low levels of serum 25-hydroxyvitamin D: nested case-control study and randomised clinical trial. The British journal of psychiatry: the journal of mental science. 2012;201(5):360–368.CrossRefGoogle Scholar
  27. 27.
    Langub MC, Herman JP, Malluche HH, Koszewski NJ. Evidence of functional vitamin D receptors in rat hippocampus. Neuroscience. 2001;104(1):49–56.CrossRefGoogle Scholar
  28. 28.
    Hoang MT, Defina LF, Willis BL, Leonard DS, Weiner MF, Brown ES. Association between low serum 25-hydroxyvitamin D and depression in a large sample of healthy adults: the Cooper Center longitudinal study. Mayo Clinic proceedings. 2011;86(11):1050–1055.CrossRefGoogle Scholar
  29. 29.
    Brouwer-Brolsma EM, Feskens EJ, Steegenga WT, de Groot LC. Associations of 25-hydroxyvitamin D with fasting glucose, fasting insulin, dementia and depression in European elderly: the SENECA study. European journal of nutrition. 2013;52(3):917–925.CrossRefGoogle Scholar
  30. 30.
    Benton MJ, White A. Osteoporosis: recommendations for resistance exercise and supplementation with calcium and vitamin D to promote bone health. Journal of community health nursing. 2006;23(4):201–211.CrossRefGoogle Scholar

Copyright information

© Serdi and Springer-Verlag International SAS, part of Springer Nature 2019

Authors and Affiliations

  • M. N. Wu
    • 1
  • F. He
    • 1
  • Q. R. Tang
    • 2
  • J. Chen
    • 2
  • X. Gu
    • 1
  • Y. J. Zhai
    • 1
  • F. D. Li
    • 1
  • T. Zhang
    • 1
  • X. Y. Wang
    • 1
  • Junfen Lin
    • 1
    Email author
  1. 1.Zhejiang Provincial Center for Disease Control and PreventionZhejiangChina
  2. 2.Haishu Center for Disease Control and PreventionNingbo, ZhejiangChina

Personalised recommendations