Dynapenic Abdominal Obesity Increases Mortality Risk Among English and Brazilian Older Adults: A 10-Year Follow-Up of the ELSA and SABE Studies
There is little epidemiological evidence demonstrating that dynapenic abdominal obesity has higher mortality risk than dynapenia and abdominal obesity alone. Our main aim was to investigate whether dynapenia combined with abdominal obesity increases mortality risk among English and Brazilian older adults over ten-year follow-up.
United Kingdom and Brazil.
Data came from 4,683 individuals from the English Longitudinal Study of Ageing (ELSA) and 1,490 from the Brazilian Health, Well-being and Aging study (SABE), hence the final sample of this study was 6,173 older adults.
The study population was categorized into the following groups: nondynapenic/ non-abdominal obese, abdominal obese, dynapenic, and dynapenic abdominal obese according to their handgrip strength (< 26 kg for men and < 16 kg for women) and waist circumference (> 102 cm for men and > 88 cm for women). The outcome was all-cause mortality over a ten-year follow-up. Adjusted hazard ratios by sociodemographic, behavioural and clinical characteristics were estimated using Cox proportional hazards models. Results: The fully adjusted model showed that dynapenic abdominal obesity has a higher mortality risk among the groups. The hazard ratios (HR) were 1.37 for dynapenic abdominal obesity (95% CI = 1.12–1.68), 1.15 for abdominal obesity (95% CI = 0.98–1.35), and 1.23 for dynapenia (95% CI = 1.04–1.45).
Dynapenia is an important risk factor for mortality but dynapenic abdominal obesity has the highest mortality risk among English and Brazilian older adults.
Key wordsDynapenia handgrip waist circumference obesity mortality
- 1.He W, Goodkind D, Kowal P. An Aging World: 2015 International Population Reports. United States Census Bureau. US Department of Commerce Economics and Statistics Administration, US Department of Health and Human Services National Institutes of Health, National Institute of Aging, 2016.Google Scholar
- 5.Clark BC, Manini TM. Sarcopenia # Dynapenia. Journal of Gerontology A: Biological Sciences Medical Sciences 2008;63A(8):829–34.Google Scholar
- 6.Clark BC, Manini TM. What is dynapenia? Nutrition 28(5):495-503.Google Scholar
- 10.Visser M, Pahor M, Taaffe DR, et al. Relationship of interleukin-6 and tumor necrosis factor-α with muscle mass and muscle strength in elderly men and women The Health ABC Study. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2002;57(5):M326–M332.CrossRefGoogle Scholar
- 19.NHLBI Obesity Education Initiative Expert Panel on the Identification, Evaluation, and Treatment of Obesity in Adults (US). Clinical Guidelines on the Identification, Evaluation, and Treatment of Overweight and Obesity in Adults: The Evidence Report. Bethesda (MD): National Heart, Lung, and Blood Institute; 1998 Sep.Google Scholar
- 20.Alexandre TS, Duarte YAO, Santos JLF, et al. Prevalence and associated factors of sarcopenia among elderly in Brazil: findings from the SABE Study. J Nutr Health Aging 2014;18(3):285–290.Google Scholar
- 21.McLean RR, Shardell MD, Alley DE, et al. Criteria for clinically relevant weakness and low lean mass and their longitudinal association with incident mobility impairment and mortality: The Foundation for the National Institutes of Health (FNIH) Sarcopenia Project. The Journals of Gerontology Series A: Biological Sciences and Medical Sciences 2014;69(5):576–583.CrossRefPubMedCentralGoogle Scholar
- 22.World Health Organization. Consultation on obesity. Obesity: preventing and managing the global epidemic. Geneva, Switzerland: WHO; 2000. WHO Technical Report Series894.Google Scholar
- 33.Hair JF, Anderson RE, Tatham RL et al. Multivariate data analysis with readings. Upper Saddle River, NJ: Prentice Hall 1995.Google Scholar
- 38.Van Gall LF, Mertens IL, De Block CE. Mechanisms linking obesity with cardiovascular disease. Nature 2006;44:878–80.Google Scholar