The journal of nutrition, health & aging

, Volume 21, Issue 10, pp 1284–1290 | Cite as

Intake of fruit and vegetables and the incident risk of cognitive disorders: A systematic review and meta-analysis of cohort studies

  • L. Wu
  • D. Sun
  • Yan TanEmail author



No quantitative assessment has been performed to specifically link the consumption of fruit and vegetables with the incident risk of cognitive disorders.


We searched the PubMed and the Embase databases (both from the inception to June 13th, 2016) for records that report the intake of fruit and vegetables and the risk of developing cognitive disorders (Alzheimer’s disease, dementia, and cognitive decline/ impairment). A generic inverse-variance method (random-effects model) was used to combine the relative risks (RRs) and 95% confidence intervals (CIs). To explore the potential sources of heterogeneity, we performed the subgroup and meta-regression analyses by pre-specified characteristics.


We identified 6 cohorts involving a total of 21,175 participants. The pooled analysis showed that consumption of fruit and vegetables was inversely associated with the incident risk of cognitive disorders, and the pooled RR (95% CI) was 0.74 (0.62, 0.88), with evidence of significant heterogeneity (I2 =68%). Furthermore, we found that the significant heterogeneity might be attributed to the ethnic difference.


Further large prospective studies should be performed to quantify the potential dose-response patterns of fruit and/or vegetables intake and to explore the role of fruit or vegetables consumption separately on cognitive disorders in different populations.


Fruit and vegetables Alzheimer’s disease dementia cognitive disorders meta-analysis 



Alzheimer’s Disease


food-frequency questionnaire


Diagnostic and Statistical Manual of Mental Disorders


National Institute of Neurological and Communicative Disorders and Stroke-Alzheimer’s Disease and Related Disorders Association


Functional Activities Questionnaire


Observed Cognitive Deterioration


Newcastle-Ottawa Scale


relative risk


hazard ratio


odds ratios

95% CI

95% confidence interval


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Copyright information

© Serdi and Springer-Verlag France 2017

Authors and Affiliations

  1. 1.Department of Epidemiology, Institute of GeriatricsChinese People’s Liberation Army General HospitalBeijingChina
  2. 2.Beijing Key Laboratory of Aging and GeriatricsChinese People’s Liberation Army General HospitalBeijingChina
  3. 3.Department of NanomedicineHouston Methodist Research InstituteHoustonUSA
  4. 4.Editorial Department, Academic Journal of Chinese PLA Medical SchoolChinese People’s Liberation Army General HospitalBeijingChina

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