Tea consumption reduces the incidence of neurocognitive disorders: Findings from the Singapore longitudinal aging study
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To examine the relationships between tea consumption habits and incident neurocognitive disorders (NCD) and explore potential effect modification by gender and the apolipoprotein E (APOE) genotype.
Population-based longitudinal study.
The Singapore Longitudinal Aging Study (SLAS).
957 community-living Chinese elderly who were cognitively intact at baseline.
We collected tea consumption information at baseline from 2003 to 2005 and ascertained incident cases of neurocognitive disorders (NCD) from 2006 to 2010. Odds ratio (OR) of association were calculated in logistic regression models that adjusted for potential confounders.
A total of 72 incident NCD cases were identified from the cohort. Tea intake was associated with lower risk of incident NCD, independent of other risk factors. Reduced NCD risk was observed for both green tea (OR=0.43) and black/oolong tea (OR=0.53) and appeared to be influenced by the changing of tea consumption habit at follow-up. Using consistent nontea consumers as the reference, only consistent tea consumers had reduced risk of NCD (OR=0.39). Stratified analyses indicated that tea consumption was associated with reduced risk of NCD among females (OR=0.32) and APOE e4 carriers (OR=0.14) but not males and non APOE e4 carriers.
Regular tea consumption was associated with lower risk of neurocognitive disorders among Chinese elderly. Gender and genetic factors could possibly modulate this association.
Key wordsTea aging neurocognitive disorders Chinese cohort study
- 10.Feng L, Ng TP, Kua EH, Preedy VR. Tea and cognitive function of elderly people -evidence from neurobiology and epidemiology. In: Preedy VR, ed. Tea in Health and Disease Prevention. 1 ed. London: Elsevier Inc., 2012:11325–1336.Google Scholar
- 24.Sheikh JI, Yesavage JA. Geriatric Depression Scale (GDS): Recent evidence and development of a shorter version. Clinical Gerontology: A Guide to Assessment and Intervention. NY: The Haworth Press, 1986:165–73.Google Scholar
- 27.Zeng Y, Chen H, Ni T, et al. GxE Interactions Between FOXO Genotypes and Tea Drinking Significantly Affect Cognitive Disability at Advanced Ages in China. J Gerontol A Biol Sci Med Sci 2014. pii: glu060. [Epub ahead of print]Google Scholar
- 28.Schmidt A, Hammann F, Wolnerhanssen B, et al. Green tea extract enhances parietofrontal connectivity during working memory processing. Psychopharmacology (Berl) 2014.Google Scholar
- 29.Panza F, Solfrizzi V, Barulli MR, Bonfiglio C, Guerra V, Osella A, Seripa D, Sabbà C, Pilotto A, Logroscino G. Coffee, tea, and caffeine consumption and prevention of late-life cognitive decline and dementia: a systematic review. J Nutr Health Aging. 2015 Mar;19(3):313–28. doi: 10.1007/s12603-014-0563-8.CrossRefPubMedGoogle Scholar