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The journal of nutrition, health & aging

, Volume 19, Issue 8, pp 856–860 | Cite as

Insulin-like growth factor-1 and resistance exercise in community dwelling old adults

  • A. Arnarson
  • O. Gudny Geirsdottir
  • Alfons Ramel
  • P. V. Jonsson
  • I. Thorsdottir
Article

Abstract

Background

Insulin-like growth factor-1 (IGF-1) is related to the preservation of lean body mass. Its decline during ageing is thought to make old adults more susceptible to sarcopenia and functional dependency. The aim of the present study was to investigate circulating total IGF-1 in old adults who engaged in a 12-weeks of progressive resistance training.

Design

Intervention study.

Setting

Community.

Participants

Old Icelandic adults (N = 235, 73.7 ± 5.7 years, 58.2% female). Intervention: Twelve-week resistance exercise program (3 times/week; 3 sets, 6-8 repetitions at 75-80% of the 1-repetition maximum) designed to increase strength and muscle mass of major muscle groups.

Measurements

IGF-1.

Results

At baseline IGF-1 was significantly associated with lean body mass and appendicular muscle mass (also when corrected for age, gender and various covariates). After the training IGF-1 decreased significantly from 112.1 ± 35.6 to 106.1 ± 35.2 µg/L during the course of the study. On and individual level, IGF-1 decreased in 59% and increased in 39% of the participants. Changes in IGF-1 were inversely related to changes in lean body mass (rho = -0.176, P = 0.013 ) and appendicular muscle mass (rho = −0.162, P = 0.019) also when corrected for protein intake, age, gender, and other covariates.

Conclusion

Serum total IGF-1 decreases after 12 weeks of resistance exercise in community dwelling old adults. When looked at IGF-1 changes for participants individually it becomes clear that IGF-1 response to resistances exercise is highly variable. Changes in IGF-1 are negatively related to changes in lean body mass during training, which supports the hypothesis that IGF-1 is redistributed from circulation into tissue during periods of active muscle building.

Key words

Elderly lean body mass physical activity 

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Copyright information

© Serdi and Springer-Verlag France 2015

Authors and Affiliations

  • A. Arnarson
    • 1
  • O. Gudny Geirsdottir
    • 1
    • 2
  • Alfons Ramel
    • 1
  • P. V. Jonsson
    • 2
    • 3
  • I. Thorsdottir
    • 1
  1. 1.Unit for Nutrition ResearchNational University Hospital of Iceland & Faculty of Food Science and Nutrition, University of IcelandReykjavikIceland
  2. 2.The Icelandic Gerontological Research CenterNational University Hospital of Iceland & Faculty of MedicineReykjavikIceland
  3. 3.Department of GeriatricsNational University Hospital of IcelandReykjavikIceland

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