The journal of nutrition, health & aging

, Volume 19, Issue 2, pp 164–168 | Cite as

Association of dietary intake and lifestyle pattern with mild cognitive impairment in the elderly

  • X. Zhao
  • L. Yuan
  • L. Feng
  • Y. Xi
  • H. Yu
  • W. Ma
  • D. Zhang
  • Rong XiaoEmail author


Introduction: Objectives

Specific diets or lifestyles have an impact on cognitive function in previous studies. However, the association of the complex action of Chinese daily diets and lifestyle patterns with mild cognitive impairment (MCI) among elderly people had not been studied exactly. The aim of this study was to explore the association of dietary and lifestyle patterns with MCI among elderly people in Beijing.


Population-based and case-control design.


The physical examination center in Xuanwu Hospital, Capital Medical University in Beijing.


A total of 404 subjects, aged 60 years old or above, with or without MCI.


The Montreal cognitive assessment (MoCA) was used to screen the subjects with MCI. All subjects were required to complete a questionnaire which was comprised of their demographic information, health status, lifestyles, and food frequency questionnaire (FFQ). Binary multivariable logistic regression was used to evaluate the potential association between MCI and these factors.


With adjustment for some factors,higher daily intake of eggs (OR, 0.975,95% CI, 0.959–0.992, P=.003) and marine products (OR, 0.96, 95% CI, 0.943–0.979, P=.000), longer time of watching TV (OR, 0.763, 95% CI, 0.628–0.928, P=.007), reading (OR, 0.540, 95% CI, 0.379–0.769, P=.001) and physical exercise (OR, 0.382, 95% CI, 0.185–0.789) had significantly decreased odds of suffering from MCI compared with the control group.


Our findings suggested that daily higher intake of eggs and marine products,watching TV, reading and physical exercise were associated with preventing the development of MCI in this population-based samples.

Key words

Dietary intake lifestyle patterns mild cognitive impairment elderly people 


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  1. 1.
    Suzana Shaharl, Lai Kuan Lee, Norfadilah Rajab, et al. Association between vitamin A, vitamin E and apolipoprotein E status with mild cognitive impairment among elderly people in low-cost residential areas. Nutritional Neuroscience 2013;16: 6–12.Google Scholar
  2. 2.
    Gauthier S, Reisberg B, Zaudig M, et al. Mild cognitive impairment. Lancet 2006;267: 1262–1270.CrossRefGoogle Scholar
  3. 3.
    Geda YE, Ragossnig M, Roberts LA, et al. Caloric Intake, Aging, and Mild Cognitive Impairment: A Population-Based Study. J Alzheimers Dis 34: 501–507.Google Scholar
  4. 4.
    Balion C, Griffith LE, Strifler L, et al. Vitamin D, cognition, and dementia: a systematic review and analysis. Neurology 2012;79: 1397–1405.CrossRefPubMedCentralPubMedGoogle Scholar
  5. 5.
    Anweiler C, Llewellyn CJ, Beauchet O. Low serum vitamin D concentrations in Alzheimer’s disease: a systematic review and meta-analysis. J. Alzheimers Dis 2012;33: 659–674.Google Scholar
  6. 6.
    Roberts RO, Geda YE, Cerhan JR, et al. Vegetables, unsaturated fats, moderate alcohol intake and mild cognitive impairment. Dement Geriatr Cogn Disord 2010;29: 413–423.CrossRefPubMedCentralPubMedGoogle Scholar
  7. 7.
    Davey DA. Alzheimer’s disease, dementia, mild cognitive impairment and the menopause: a ‘window of opportunity’? Women’s Health 2013;9: 279–290.Google Scholar
  8. 8.
    Wang Z, Dong B, Zeng G, et al. Is there an association between mild cognitive impairment and dietary pattern in chinese elderly? Results from a cross-sectional. population study. BMC Public Health 2010;10: 595–607.CrossRefPubMedCentralPubMedGoogle Scholar
  9. 9.
    Henderson VW, John JA, Hodis HN, et al. Long-term soy isoflavone supplementation and cognition in women: a randomized, controlled trial. Neurology 2012;78: 1841–1848.CrossRefPubMedCentralPubMedGoogle Scholar
  10. 10.
    Geda YE, Silber TC, Roberts RO, et al. Computer Activities, Physical Exercise, Aging, and Mild Cognitive Impairment: A Population-Based Study. Mayo Clin Proc 2012;87: 437–442.CrossRefPubMedCentralPubMedGoogle Scholar
  11. 11.
    Ding BJ, Ma WW, He LL, et al. Soybean isoflavone alleviates ß-amyloid 1-42 induced inflammatory response to improve learning and memory ability by down regulation of Toll-like receptor 4 expression and nuclear factor-γB activity in rats. Int. J. Devl Neuroscience 2011;29: 537–542.CrossRefGoogle Scholar
  12. 12.
    Yuan L, Zhou X, Li D, et al. Pattern recognition receptors involved in the inflammatory attenuating effects of soybean isoflavone in ß-amyloid peptides 1-42 treated rats. Neurosci Lett 2012;506: 266–270.CrossRefPubMedGoogle Scholar
  13. 13.
    Yang YX, Wang GY, Pan XC. China Food Composition. 2nd ed. Peking University Medical Press. Beijing.Google Scholar
  14. 14.
    Lu J, Li D, Li F, et al. Montreal cognitive assessment in detecting cognitive impairment in Chinese elderly individuals: A population-based study. Journal of Geriatric Psychiatry and Neurology 2011;24: 184–190.CrossRefPubMedGoogle Scholar
  15. 15.
    Su X, Shang L, Xu QL, et al. Prevalence and Predictors of Mild Cognitive Impairment in Xi’an: A Community-Based Study among the Elders. PLoS One 2014;9: e83217. doi: 10.1371 [Epub ahead of print]CrossRefGoogle Scholar
  16. 16.
    Nie H, Xu Y, Liu B, et al. The prevalence of mild cognitive impairment about elderly population in China: a meta-analysis. Int J Geriatr Psychiatry 2011;26: 558–563.CrossRefPubMedGoogle Scholar
  17. 17.
    Lee LK, Shahar S, Chin AV, et al. Prevalence of gender disparities and predictors affecting the occurrence of mild cognitive impairment (MCI). Arch Gerontol Geriatr 2012;54: 185–191.CrossRefPubMedGoogle Scholar
  18. 18.
    Jia J, Zhou A, Wei C, et al. The prevalence of mild cognitive impairment and its etiological subtypes in elderly Chinese. Alzheimers Dement, 2014; [Epub ahead of print].Google Scholar
  19. 19.
    Trichopoulou A, Costacou T, Bamia C, et al. Adherence to a Mediterranean diet and survival in a Greek population. N Engl J Med 2003;348: 2599–2608.CrossRefPubMedGoogle Scholar
  20. 20.
    Willett WC, Sacks F, Trichopoulou A, et al. Mediterranean diet pyramid: a cultural model for healthy eating. Am J Clin Nutr 1995;61: 1402S–1406S.PubMedGoogle Scholar
  21. 21.
    Martínez-Lapiscina EH, Clavero P, Toledo E, et al. Virgin olive oil supplementation and long-term cognition: the PREDIMED-NAVARRA randomized, trial. J Nutr Health Aging 2013;17(6): 544–52.CrossRefPubMedGoogle Scholar
  22. 22.
    Singh B, Parsaik AK, Mielke MM, et al. Association of Mediterranean Diet with Mild Cognitive Impairment and Alzheimer’s Disease: A Systematic Review and Meta-Analysis. J Alzheimers Dis 2014;39: 271–282.PubMedCentralPubMedGoogle Scholar
  23. 23.
    Solfrizzi V, Capurso C, D’Introno A et al. Lifestyle-related factors in predementia and dementia syndromes. Expert Rev Neurother 2008;8: 133–158.CrossRefPubMedGoogle Scholar
  24. 24.
    Geda YE, Roberts RO, Knopman DS, et al. Physical exercise, aging, and mild cognitive impairment: a population-based study. Arch Neurol 2010;67: 80–86.PubMedCentralPubMedGoogle Scholar
  25. 25.
    Geda YE, Topazian HM, Lewis RA, et al. Engaging in cognitive activities, aging, and mild cognitive impairment: a population-based study. J Neuropsychiatry Clin Neurosci 2011;23: 149–154.CrossRefPubMedCentralPubMedGoogle Scholar
  26. 26.
    Lee LK, Shahar S, Chin AV, Yusoff NA. Docosahexaenoic acid-concentrated fish oil supplementation in subjects with mild cognitive impairment (MCI): a 12-month randomised, double-blind, placebo-controlled trial. Psychopharmacology (Berl). 2012;225(3): 605–12.CrossRefGoogle Scholar
  27. 27.
    Boripuntakul S, Lord SR, Brodie MA, et al. Spatial variability during gait initiation while dual tasking is increased in individuals with mild cognitive impairment. J Nutr Health Aging 2014;18(3): 307–12.CrossRefPubMedGoogle Scholar

Copyright information

© Serdi and Springer-Verlag France 2014

Authors and Affiliations

  • X. Zhao
    • 1
  • L. Yuan
    • 1
    • 2
  • L. Feng
    • 1
  • Y. Xi
    • 1
  • H. Yu
    • 1
  • W. Ma
    • 1
  • D. Zhang
    • 1
  • Rong Xiao
    • 1
    • 2
    Email author
  1. 1.School of Public HealthCapital Medical UniversityBeijingPR China
  2. 2.Beijing Key Laboratory of Environmental ToxicologyCapital Medical UniversityBeijingChina

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