The journal of nutrition, health & aging

, Volume 18, Issue 5, pp 496–502 | Cite as

Long-term intake of nuts in relation to cognitive function in older women

  • Jacqueline O’Brien
  • O. Okereke
  • E. Devore
  • B. Rosner
  • M. Breteler
  • F. Grodstein
Article

Abstract

Objective

Nuts contain nutrients that may benefit brain health; thus, we examined long-term intake of nuts in relation to cognition in older women.

Design

Population-based prospective cohort study.

Setting

Academic research using data from the Nurses’ Health Study.

Participants

Nut intake was assessed in a food-frequency questionnaire beginning inl980, and approximately every four years thereafter. Between 1995–2001, 16,010 women age 70 or older (mean age = 74 years) without a history of stroke were administered 4 repeated telephone-based cognitive interviews over 6 years. Our final sample included 15,467 women who completed an initial cognitive interview and had complete information on nut intake.

Main Outcome Measures

The Telephone Interview for Cognitive Status (TICS), a global score averaging the results of all tests (TICS, immediate and delayed verbal recall, category fluency, and attention), and a verbal memory score averaging the results of tests of verbal recall.

Results

In multivariable-adjusted linear regression models, higher long-term total nut intake was associated with better average cognitive status for all cognitive outcomes. For the global composite score combining all tests, women consuming at least 5 servings of nuts/week had higher scores than non-consumers (mean difference=0.08 standard units, 95% confidence interval 0.00–0.15; p-trend=0.003). This mean difference of 0.08 is equivalent to the mean difference we find between women 2 years apart in age. Long-term intake of nuts was not associated with rates of cognitive decline.

Conclusions

Higher nut intake may be related to better overall cognition at older ages, and could be an easily-modifiable public health intervention.

Key words

Cognition cognitive decline cognitive function cohort study diet epidemiology nutrition 

Abbreviations

ALA

α-linolenic acid

BMI

body mass index

CI

confidence interval

FFQ

food-frequency questionnaire

MET-h

metabolic equivalence hour

MUFA

monounsaturated fatty acid

NHS

Nurses’ Health Study

PUFA

polyunsaturated fatty acid

SD

standard deviation

TICS

Telephone Interview for Cognitive Status

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References

  1. 1.
    Brufau G, Boatella J, Rafecas M: Nuts: source of energy and macronutrients. The British journal of nutrition 2006, 96Suppl 2:S24–S28.PubMedCrossRefGoogle Scholar
  2. 2.
    Mukuddem-Petersen J, Oosthuizen W, Jerling JC: A systematic review of the effects of nuts on blood lipid profiles in humans. The Journal of nutrition 2005, 135:2082–2089.PubMedGoogle Scholar
  3. 3.
    Fraser GE, Sabate J, Beeson WL, Strahan TM: A possible protective effect of nut consumption on risk of coronary heart disease. The Adventist Health Study. Archives of Internal Medicine 1992, 152:1416–1424.PubMedCrossRefGoogle Scholar
  4. 4.
    Hu FB, Stampfer MJ, Manson JE, Rimm EB, Colditz GA, Rosner BA, Speizer FE, Hennekens CH, Willett WC: Frequent nut consumption and risk of coronary heart disease in women: prospective cohort study. BMJ (Clinical research ed) 1998. 317:1341–1345.CrossRefGoogle Scholar
  5. 5.
    Kushi LH, Folsom AR, Prineas RJ, Mink PJ, Wu Y, Bostick RM: Dietary antioxidant vitamins and death from coronary heart disease in postmenopausal women. The New England journal of medicine 1996, 334:1156–1162.PubMedCrossRefGoogle Scholar
  6. 6.
    Jiang R, Manson JE, Stampfer MJ, Liu S, Willett WC, Hu FB: Nut and peanut butter consumption and risk of type 2 diabetes in women. JAMA: the journal of the American Medical Association 2002, 288:2554–2560.CrossRefGoogle Scholar
  7. 7.
    Jenkins DJ, Hu FB, Tapsell LC, Josse AR, Kendall CW: Possible benefit of nuts in type 2 diabetes. The Journal of nutrition 2008, 138:1752S–1756S.PubMedGoogle Scholar
  8. 8.
    Yehuda S, Rabinovitz S, Mostofsky DI: Essential fatty acids and the brain: from infancy to aging. Neurobiology of aging 2005, 26Suppl 1:98–102.PubMedCrossRefGoogle Scholar
  9. 9.
    Nooyens AC, Bueno-de-Mesquita HB, van Boxtel MP, van Gelder BM, Verhagen H, Verschuren WM: Fruit and vegetable intake and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. The British journal of nutrition 2011, 106:752–761.PubMedCrossRefGoogle Scholar
  10. 10.
    Samieri C, Grodstein F, Rosner BA, Kang JH, Cook NR, Manson JE, Buring JE, Willett WC, Okereke OI: Mediterranean diet and cognitive function in older age. Epidemiology 2013, 24:490–499.PubMedCrossRefGoogle Scholar
  11. 11.
    Samieri C, Okereke OI, E ED, Grodstein F: Long-term adherence to the Mediterranean diet is associated with overall cognitive status, but not cognitive decline, in women. J Nutr 2013, 143:493–499.PubMedCentralPubMedCrossRefGoogle Scholar
  12. 12.
    Willett WC, Sampson L, Browne ML, Stampfer MJ, Rosner B, Hennekens CH, Speizer FE: The use of a self-administered questionnaire to assess diet four years in the past. American Journal of Epidemiology 1988, 127:188–199.PubMedGoogle Scholar
  13. 13.
    Willett WC, Sampson L, Stampfer MJ, Rosner B, Bain C, Witschi J, Hennekens CH, Speizer FE: Reproducibility and validity of a semiquantitative food frequency questionnaire. American Journal of Epidemiology 1985, 122:51–65.PubMedGoogle Scholar
  14. 14.
    Salvini S, Hunter DJ, Sampson L, Stampfer MJ, Colditz GA, Rosner B, Willett WC: Food-based validation of a dietary questionnaire: the effects of week-to-week variation in food consumption. International journal of epidemiology 1989, 18:858–867.PubMedCrossRefGoogle Scholar
  15. 15.
    Tabert MH, Manly JJ, Liu X, Pelton GH, Rosenblum S, Jacobs M, Zamora D, Goodkind M, Bell K, Stern Y, Devanand DP: Neuropsychological prediction of conversion to Alzheimer disease in patients with mild cognitive impairment. Archives of General Psychiatry 2006, 63:916–924.PubMedCrossRefGoogle Scholar
  16. 16.
    Stampfer MJ, Kang JH, Chen J, Cherry R, Grodstein F: Effects of moderate alcohol consumption on cognitive function in women. The New England journal of medicine 2005, 352:245–253.PubMedCrossRefGoogle Scholar
  17. 17.
    Kang JH, Ascherio A, Grodstein F: Fruit and vegetable consumption and cognitive decline in aging women. Annals of Neurology 2005, 57:713–720.PubMedCrossRefGoogle Scholar
  18. 18.
    Devore EE, Kang JH, Breteler MM, Grodstein F: Dietary intakes of berries and flavonoids in relation to cognitive decline. Annals of Neurology 2012.Google Scholar
  19. 19.
    Alexiadou K, Katsilambros N: Nuts: anti-atherogenic food? European journal of internal medicine 2011, 22:141–146.PubMedCrossRefGoogle Scholar
  20. 20.
    Ellsworth JL, Kushi LH, Folsom AR: Frequent nut intake and risk of death from coronary heart disease and all causes in postmenopausal women: the Iowa Women’s Health Study. Nutrition, metabolism, and cardiovascular diseases: NMCD 2001, 11:372–377.PubMedGoogle Scholar
  21. 21.
    Griel AE, Kris-Etherton PM: Tree nuts and the lipid profile: a review of clinical studies. The British journal of nutrition 2006, 96Suppl 2:S68–78.PubMedCrossRefGoogle Scholar
  22. 22.
    Casas-Agustench P, Bullo M, Salas-Salvado J: Nuts, inflammation and insulin resistance. Asia Pacific Journal of Clinical Nutrition 2010, 19:124–130.PubMedGoogle Scholar
  23. 23.
    Casas-Agustench P, Lopez-Uriarte P, Ros E, Bullo M, Salas-Salvado J: Nuts, hypertension and endothelial function. Nutrition, metabolism, and cardiovascular diseases: NMCD 2011, 21Suppl 1:S21–33.PubMedCrossRefGoogle Scholar
  24. 24.
    Grodstein F: Cardiovascular risk factors and cognitive function. Alzheimer’s & dementia: the journal of the Alzheimer’s Association 2007, 3:S16–22.CrossRefGoogle Scholar
  25. 25.
    Haider S, Batool Z, Tabassum S, Perveen T, Saleem S, Naqvi F, Javed H, Haleem DJ: Effects of Walnuts (Juglans regia) on Learning and Memory Functions. Plant Foods for Human Nutrition (Dordrecht, Netherlands) 2011.Google Scholar
  26. 26.
    Shatenstein B, Gauvin L, Keller H, Richard L, Gaudreau P, Giroux F, Gray-Donald K, Jabbour M, Morais JA, Payette H: Baseline determinants of global diet quality in older men and women from the NuAge cohort. J Nutr Health Aging 2013, 17:419–425.PubMedCrossRefGoogle Scholar

Copyright information

© Serdi and Springer-Verlag France 2014

Authors and Affiliations

  • Jacqueline O’Brien
    • 1
    • 2
    • 6
  • O. Okereke
    • 1
    • 2
    • 3
  • E. Devore
    • 1
  • B. Rosner
    • 1
    • 4
  • M. Breteler
    • 2
    • 5
  • F. Grodstein
    • 1
    • 2
  1. 1.Channing Division of Network Medicine, Department of MedicineBrigham & Women’s Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of EpidemiologyHarvard School of Public HealthBostonUSA
  3. 3.Department of PsychiatryBrigham & Women’s Hospital and Harvard Medical SchoolBostonUSA
  4. 4.Department of BiostatisticsHarvard School of Public HealthBostonUSA
  5. 5.German Center for Neurodegenerative DiseasesBonnGermany
  6. 6.Channing Division of Network MedicineBrigham and Women’s HospitalBostonUSA

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