The journal of nutrition, health & aging

, Volume 16, Issue 5, pp 422–425 | Cite as

Anorexia of aging: A true geriatric syndrome



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  1. 1.
    Inouye SK, Studenski S, Tinetti ME, Kuchel GA. Geriatric syndromes: clinical, research, and policy implications of a core geriatric concept. J Am Geriatr Soc 2007;55:780–791.PubMedCrossRefGoogle Scholar
  2. 2.
    Morley JE. Anabolic steroids and frailty. J Am Med Dir Assoc 2010;11:533–536.PubMedCrossRefGoogle Scholar
  3. 3.
    Gobbens RJ, van Assen MA, Luijkx KG, et al. Determinants of frailty. J Am Med Dir Assoc 2010;11:356–364.PubMedCrossRefGoogle Scholar
  4. 4.
    Gobbens RJ, van Assen MA, Luijkx KG, et al. The Tilburg Frailty Indicator: Psychometric properties. J Am Med Dir Assoc 2010;11:344–355.PubMedCrossRefGoogle Scholar
  5. 5.
    Abellan van Kan G, Rolland YM, Morley JE, Vellas B. Frailty: Toward a clinical definition. J Am Med Dir Assoc 2008;9:71–72.PubMedCrossRefGoogle Scholar
  6. 6.
    Rockwood K, Abeysundera MJ, Mitnitski A. How should we grade frailty in nursing home patients? J Am Med Dir Assoc 2007;8:595–603.PubMedCrossRefGoogle Scholar
  7. 7.
    Morley JE. Frailty: Diagnosis and management. J Nutr Health Aging 2011;15:667–670.PubMedCrossRefGoogle Scholar
  8. 8.
    Abellan van Kan G, Rolland Y, Bergman H, et al. The I.A.N.A. Task Force on frailty assessment of older people in clinical practice. J Nutr Health Aging 2008;12:29–37.PubMedCrossRefGoogle Scholar
  9. 9.
    Morley JE. Developing novel therapeutic approaches to frailty. Curr Pharm Des 2009;15:3384–3395.PubMedCrossRefGoogle Scholar
  10. 10.
    Mitnitski A, Fallah N, Rockwood MR, Rockwood K. Transitions in cognitive status in relation to frailty in older adults: A comparison of three frailty measures. J Nutr Health Aging 2011;15:863–867.PubMedCrossRefGoogle Scholar
  11. 11.
    Sirola J, Pitkala KH, Tilvis RS, Miettinen TA, Strandberg TE. Definition of frailty in older men according to quesitonnaire data (RAND-36/SF-36): The Helsinki Businessmen Study. J Nutr Health Aging 2011;15:783–787.PubMedCrossRefGoogle Scholar
  12. 12.
    Morley JE, Silver AJ. Anorexia in the elderly. Neurobiol Aging 1988;9:9–16.PubMedCrossRefGoogle Scholar
  13. 13.
    Landi F, Liperoti R, Lattanzio F, et al. Effects of anorexia on mortality among older adults receiving home care: An observation study. J Nutr Health Aging 2012;16:79–83.PubMedCrossRefGoogle Scholar
  14. 14.
    Cornali C, Franzoni S, Frisoni GB, Trabucchi M. Anorexia as an independent predictor of mortality. J Am Geriatr Soc 2005;53:354–355.PubMedCrossRefGoogle Scholar
  15. 15.
    Donini LM, Dominguez LJ, Barbagallo M, et al. Senile anorexia in different geriatric settings in Italy. J Nutr Health Aging 2011;15:775–781.PubMedCrossRefGoogle Scholar
  16. 16.
    Donini LM, Savina C, Piredda M, et al. Senile anorexia in acute-ward and rehabilitations settings J Nutr Health Aging 2008;12:511–517.PubMedCrossRefGoogle Scholar
  17. 17.
    Landi F, Russo A, Liperoti R, et al. Anorexia, physical function, and incident disability among the frail elderly population: Results from the ilSIRENTE study. J Am Med Dir Assoc 2010;11:268–274.PubMedCrossRefGoogle Scholar
  18. 18.
    Morley JE. Clinical practice in nursing homes as a key for progress. J Nutr Health Aging 2010;14:586–593.PubMedCrossRefGoogle Scholar
  19. 19.
    Morley JE. Anorexia, weight loss, and frailty. J Am Med Dir Assoc 2010;11:225–228.PubMedCrossRefGoogle Scholar
  20. 20.
    Landi F, Laviano A, Cruz-Jentoft AJ. The anorexia of aging: Is it a geriatric syndrome? J Am Med Dir Assoc 2010;11:153–156.PubMedCrossRefGoogle Scholar
  21. 21.
    Wilson MM, Thomas DR, Rubenstein LZ, et al. Appetite assessment: Simple appetite questionnaire predicts weight loss in community-dwelling adults and nursing home residents. Am J Clin Nutr 2005;82:1074–1081.PubMedGoogle Scholar
  22. 22.
    Rolland Y, Perrin A, Gardette V, et al. Screening older people at risk of malnutrition or malnourished using the Simplified Nutritional Appetite Questionnaire (SNAQ): A comparison with the Mini-Nutritional Assessment (MNA) tool. J Am Med Dir Assoc 2012;13:31–34.PubMedCrossRefGoogle Scholar
  23. 23.
    Morley JE. Assessment of malnutrition in older persons: A focus on the Mini Nutritional Assessment. J Nutr Health Aging 2011;15:87–90.PubMedCrossRefGoogle Scholar
  24. 24.
    Volkert D, Saeglitz C, Gueldenzoph H, et al. Undiagnosed malnutrition and nutrition-related problems in geriatric patients. J Nutr Health Aging 2010;14:387–392.PubMedCrossRefGoogle Scholar
  25. 25.
    Cansado P, Ravasco P, Camilo M. A longitudinal study of hospital undernutrition in the elderly: Comparison of four validated methods. J Nutr Health Aging 2009;13:159–164.PubMedCrossRefGoogle Scholar
  26. 26.
    Kaiser MJ, Bauer JM, Ramsch C, et al; MNA-International Group. Validation of the Mini Nutritional Assessment short-form (MNA-SF): A practical tool for identification of nutritional status. J Nutr Health Aging 2009;13:782–788.PubMedCrossRefGoogle Scholar
  27. 27.
    Vellas B, Villars H, Abellan G, et al. Overview of the MNA—Its history and challenges. J Nutr Health Aging 2006;10:456–463.PubMedGoogle Scholar
  28. 28.
    Morley JE. Undernutrition: A major problem in nursing homes. J Am Med Dir Assoc 2011;12:243–246.PubMedCrossRefGoogle Scholar
  29. 29.
    Vellas B, Villars H, Abellan G, et al. Overview of the MNA—Its history and challenges. J Nutr Health Aging 2005;10:456–463.Google Scholar
  30. 30.
    Salva A, Andrieu S, Fernandez E, et al; NutriAlz Group. Health and nutritional promotion program for patients with dementia (NutriAlz Study): Design and baseline data. J Nutr Health Aging 2009;13:529–537.PubMedCrossRefGoogle Scholar
  31. 31.
    MacIntosh C, Morley JE, Chapman IM. The anorexia of aging. Nutrition 2000;16:983–995.PubMedCrossRefGoogle Scholar
  32. 32.
    Kmiec Z. Central control of food intake in aging. Interdiscip Top Gerontol 2010;37:37–50.PubMedCrossRefGoogle Scholar
  33. 33.
    Gosnell BA, Levine AS, Morley JE. The effects of aging on opioid modulation of feeding in rats. Life Sci. 1983;32:2793–2799.PubMedCrossRefGoogle Scholar
  34. 34.
    Gruenewald DA, Marck BT, Matsumoto AM. Fasting-induced increases in food intake and neuropeptide Y gene expression are attenuated in aging male Brown Norway rats. Endocrinology 1996;137:4460–4467.PubMedCrossRefGoogle Scholar
  35. 35.
    Blanton CA, Horwitz BA, Blevins JE, et al. Reduced feeding response of neuropeptide Y in senescent Fischer 344 rats. Am J Physiol Regul Integr Comp Physiol 2001;280:1052–1060.Google Scholar
  36. 36.
    Coppola JD, Horwitz BA, Hamilton J, et al. Expression of NPY Y1 and Y5 receptors in the hypothalamic paraventricular nucleus of aged Fischer 344 rats. Am J Physiol Regul Integr Comp Physiol 2004;287:69–75.CrossRefGoogle Scholar
  37. 37.
    Takano S, Kanai S, Hosoya H, et al. Orexin-A does not stimulate food intake in old rats. Am J Physiol Gastrointest Liver Physiol 2004;287:1182–1187.CrossRefGoogle Scholar
  38. 38.
    Wolden-Hanson T, Marck BT, Matsumoto AM. Blunted hypothalamic neuropeptide gene expression in response to fasting, but preservation of feeding responses to AgRP in aging male Brown Norway rats. Am J Physiol Regul Integr Comp Physiol 2004;287-138–287-146.Google Scholar
  39. 39.
    Winkels RM, Jolink-Stoppelenburg A, de Graaf K, et al. Energy intake compensation after 3 weeks of restricted energy intake in young and elderly men. J Am Med Dir Assoc 2011;12:277–286.PubMedCrossRefGoogle Scholar
  40. 40.
    MacIntosh CG, Morley JE. Wishart J, et al. Effect of exogenous cholecystokinin (CCK)-8 on food intake and plasma CCK, leptin, and insulin concentrations in older and young adults: Evidence for increased CCK activity as a cause of the anorexia of aging. J Clin Endocrinol Metab 2001;86:5830–5837.PubMedCrossRefGoogle Scholar
  41. 41.
    Di Francesco V, Barazzoni R, Bissoli L, et al. The quantity of meal fat influences the profile of postprandial hormones as well as hunger sensation in healthy elderly people. J Am Med Dir Assoc 2010;11:188–193.PubMedCrossRefGoogle Scholar
  42. 42.
    Jones KL, Doran SM, Hveem K, et al. Relation between postprandial satiation and antral area in normal subjects. Am J Clin Nutr 1997;66:127–132.PubMedGoogle Scholar
  43. 43.
    Sturm K, MacIntosh CG, Parker BA, et al. Appetite, food intake, and plasma concentrations of cholecystokinin, ghrelin, and other gastrointestinal hormones in undernourished older women and well-nourished young and older women. J Clin Endocrinol Metab 2003;88:3747–3755.PubMedCrossRefGoogle Scholar
  44. 44.
    Sturm K, Parker B, Wishart J, et al. Energy intake and appetite are related to antral area in healthy young and older subjects. Am J Clin Nutr 2004;80:656–667.PubMedGoogle Scholar
  45. 45.
    MacIntosh CG, Horowitz M, Verhagen MA, et al. Effect of small intestinal nutrient infusion on appetite, gastrointestinal hormone release, and gastric myoelectrical activity in young and older men. Am J Gastroenterol 2001;96:997–1007.PubMedCrossRefGoogle Scholar
  46. 46.
    Rolland YM, Perry HM 3rd, Patrick P, Banks WA, Morley JE. Leptin and adiponectin levels in middle-aged postmenopausal women: associations with lifestyle habits, hormones, and inflammatory markers—a cross-sectional study. Metabolism. 2006;55:1630–1636.PubMedCrossRefGoogle Scholar
  47. 47.
    Perry HM 3rd, Miller DK, Patrick P, Morley JE. Testosterone and leptin in older African-American men: relationship to age, strength function, and season. Metabolism. 2000;49:1085–1091.PubMedCrossRefGoogle Scholar
  48. 48.
    Baumgartner RN, Ross RR, Waters DL, et al. Serum leptin in elderly people: Associations with sex hormones, insulin, and adipose tissue volumes. Obes Res 1999;7:141–149.PubMedGoogle Scholar
  49. 49.
    van Symelbeke V, Jiang T, Pfitzenmeyer P. Change in taste preference in undernourished elderly hospitalized subjects during periods of infection and convalescence. J Nutr Health Aging 2009;13:40–45.CrossRefGoogle Scholar
  50. 50.
    Essed NH, Oerlemans P, Hoek M, et al. Optimal preferred MSG concentration in potatoes, spinach and beef and their effect on intake in institutionalized elderly people. J Nutr Health Aging 2009;13:769–775.PubMedCrossRefGoogle Scholar
  51. 51.
    Donini LM, Savina C, Cannella C. Nutritional interventions in the anorexia of aging. J Nutr Health Aging 2010;14:494–496.PubMedCrossRefGoogle Scholar
  52. 52.
    Nijs K, de Graaf C, van Staveren WA, de Groot LC. Malnutrition and mealtime ambiance in nursing homes. J Am Med Dir Assoc 2009;10:226–229.PubMedCrossRefGoogle Scholar
  53. 53.
    Simmons SF, Zhuo X, Keller E. Cost-effectiveness of nutrition interventions in nursing home residents: A pilot intervention. J Nutr Health Aging 2010;14:367–372.PubMedCrossRefGoogle Scholar
  54. 54.
    Morley JE, Kraenzle D. Causes of weight loss in a community nursing home. J Am Geriatr Soc 1994;42:583–585.PubMedGoogle Scholar
  55. 55.
    Rolland Y, Kim MJ, Gammack JK, et al. Office management of weight loss in older persons. Am J Med 2006;119:1019–1026.PubMedCrossRefGoogle Scholar
  56. 56.
    Wilson MM, Vaswani S, Liu D, Morley JE, Miller DK. Prevalence and causes of undernutrition in medical outpatients. Am J Med 1998;104:56–63.PubMedCrossRefGoogle Scholar
  57. 57.
    Bourdel-Marchasson I. How to improve nutritional support in geriatric institutions. J Am Med Dir Assoc 2010;11:13–20.PubMedCrossRefGoogle Scholar
  58. 58.
    German L, Feldblum I, Bilenko N, et al. Depressive symptoms and risk for malnutrition among hospitalized elderly people. J Nutr Health Aging 2008;12:313–318.PubMedCrossRefGoogle Scholar
  59. 59.
    Lo D, Paniagua MA, Thomas DR. Missed opportunities: Nursing home providers’ ability to identify and recognize depressive symptoms. J Am Med Dir Assoc 2010;11:680–683.PubMedCrossRefGoogle Scholar
  60. 60.
    Damian J, Pastor-Barriuso R, Valderrama-Gama E. Descriptive epidemiology of undetected depression in institutionalized older people. J Am Med Dir Assoc 2010;11:312–319.PubMedCrossRefGoogle Scholar
  61. 61.
    Cabrera MA, Mesas AE, Garcia AR, de Andrade SM. Malnutrition and depression among community-dwelling elderly people. J Am Med Dir Assoc 2007;8:582–584.PubMedCrossRefGoogle Scholar
  62. 62.
    German L, Kahana C, Rosenfeld V, et al. Depressive symptoms are associated with food insufficiency and nutritional deficiencies in poor community-dwelling elderly people. J Nutr Health Aging 2011;15:3–8.PubMedCrossRefGoogle Scholar
  63. 63.
    Torres SJ, McCabe M, Nowson CA. Depression, nutritional risk and eating behaviour in older caregivers. J Nutr Health Aging 2010;14:442–448.PubMedCrossRefGoogle Scholar
  64. 64.
    Morley JE. Depression in nursing home residents. J Am Med Dir Assoc 2010;11:301–303.PubMedCrossRefGoogle Scholar
  65. 65.
    Thakur M, Blazer DG. Depression in long-term care. J Am Med Dir Assoc 2008;9:82–87.PubMedCrossRefGoogle Scholar
  66. 66.
    Morley JE. The strange case of an older woman who was cured by being allowed to refuse therapy. J Am Geriatr Soc 1993;41:1012–1013.PubMedGoogle Scholar
  67. 67.
    Engin S, Ozturk M, Engin N, Kulaksizoglu IB. Dark side of the town: Depressive symptoms in disadvantaged senior citizens. J Nutr Health Aging 2010;14:483–487.PubMedCrossRefGoogle Scholar
  68. 68.
    Hsieh YM, Sung TS, Wan KS. A survey of nutrition and health status of solitary and non-solitary elders in Taiwan. J Nutr Health Aging 2010;14:11–14.PubMedCrossRefGoogle Scholar
  69. 69.
    Krahn DD, Gosnell BA, Levine AS, Morley JE. Behavioral effects of corticotropin-releasing factor: localization and characterization of central effects. Brain Res 1988;443:63–9.PubMedCrossRefGoogle Scholar
  70. 70.
    Morley JE. Dementia-related agitation. J Am Med Dir Assoc 2011;12:611–612.e2.PubMedCrossRefGoogle Scholar
  71. 71.
    Fitzgerald SP, Bean NG. An analysis for the interactions between individual comorbidities and their treatments—implications for guidelines and polypharmacy. J Am Med Dir Assoc 2010;11:475–484.PubMedCrossRefGoogle Scholar
  72. 72.
    Bronskill SE, Gill SS, Paterson JM, et al. Exploring variation in rates of polypharmacy across long term care homes. J Am Med Dir Assoc 2012;13:309.e15–21.CrossRefGoogle Scholar
  73. 73.
    Tamura BK, Bell CL, Lubimir K, et al. Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project. J Am Med Dir Assoc 2011;12:326–330.PubMedCrossRefGoogle Scholar
  74. 74.
    Gokce Kutsal Y, Barak A, Atalay A, et al. Polypharmacy in the elderly: A multicenter study. J Am Med Dir Assoc 2009;10:486–490.PubMedCrossRefGoogle Scholar
  75. 75.
    Morley JE. Polypharmacy in the nursing home. J Am Med Dir Assoc 2009;10:289–291.PubMedCrossRefGoogle Scholar
  76. 76.
    Miles RW. A conversation: Polypharmacy in the nursing home. J Am Med Dir Assoc 2010;11:296–297.PubMedCrossRefGoogle Scholar
  77. 77.
    Charlton KE, Nichols C, Bowden S, et al. Older rehabilitation patients are at high risk of malnutrition: Evidence from a large Australian database. J Nutr Health Aging 2010;14:622–628.PubMedCrossRefGoogle Scholar
  78. 78.
    Salva A, Coll-Planas L, Bruce S, et al; Task Force on Nutrition and Ageing of the IAGG and the IANA. Nutritional assessment of residents in long-term care facilities (LTCFs): Recommendations of the task force on nutrition and ageing of the IAGG European region and the IANA. J Nutr Health Aging 2009;13:475–483.PubMedCrossRefGoogle Scholar
  79. 79.
    Kumar Das A, Pillai A, Das L. Why don’t elderly hospital inpatients eat adequately? J Nutr Health Aging 2009;13:584.PubMedGoogle Scholar
  80. 80.
    Salva A, Andrieu S, Fernandez E, et al; NutrAlz group. Health and nutrition promotion program for patients with dementia (NutriAlz): Cluster randomized trial. J Nutr Health Aging 2011;15:822–830.PubMedCrossRefGoogle Scholar
  81. 81.
    Wirth R, Smoliner C, Sieber CC, Volkert D. Cognitive function is associated with body composition and nutritional risk of geriatric patients. J Nutr Health Aging 2011;15:706–710.PubMedCrossRefGoogle Scholar
  82. 82.
    Paslakis G, G, Gilles M, Frankhauser P, et al. Two cases of primary hyperparathyroidism with depressive and cognitive symptoms. J Nutr Health Aging 2010;14:798–799.PubMedCrossRefGoogle Scholar
  83. 83.
    Altenhoevel A, Norman K, Smoliner C, Peroz I. The impact of self-perceived masticatory function on nutrition and gastrointestinal complaints in the elderly. J Nutr Health Aging 2012;16:175–178.PubMedCrossRefGoogle Scholar
  84. 84.
    Boczko F. Patients’ awareness of symptoms of dysphagia. J Am Med Dir Assoc 2006;7:587–590.PubMedCrossRefGoogle Scholar
  85. 85.
    Thomas DR. Hard to swallow: Management of dysphagia in nursing home residents. J Am Med Dir Assoc 2008;9:455–458.PubMedCrossRefGoogle Scholar
  86. 86.
    Campbell-Taylor I. Oropharyngeal dysphagia in long-term care: Misperceptions of treatment efficacy. Campbell-Taylor I. J Am Med Dir Assoc 2008;9:523–531.PubMedCrossRefGoogle Scholar
  87. 87.
    Lindbloom EJ, Brandt J, Hough LD, Meadows SE. Elder mistreatment in the nursing home: A systematic review. J Am Med Dir Assoc 2007;8:610–616.PubMedCrossRefGoogle Scholar
  88. 88.
    Archbald-Pannone L, Sevilleja JE, Guerrant R. Diarrhea, clostridium difficile, and intestinal inflammation in residents of a long-term care facility. J Am Med Dir Assoc 2010;11:263–267.PubMedCrossRefGoogle Scholar
  89. 89.
    Morley JE, Anker SD, Evans WJ. Cachexia and aging: An update based on the Fourth International Cachexia Meeting. J Nutr Health Aging 2009;13:47–55.PubMedCrossRefGoogle Scholar
  90. 90.
    Yukawa M, Brown-Chang J, Callahan HS, Spiekerman CF, Weigle DS. Circulating TNF alpha receptor levels identify older adults who fail to regain weight after acute weight loss. J Nutr Health Aging 2010;14:716–720.PubMedCrossRefGoogle Scholar
  91. 91.
    Yeh SS, Lovitt S, Schuster MW. Pharmacological treatment of geriatric cachexia: Evidence and safety in perspective. J Am Med Dir Assoc 2007;8:363–377.PubMedCrossRefGoogle Scholar
  92. 92.
    Yeh SS, Blackwood K, Schuster MW. The cytokine basis of cachexia and its treatment: Are they ready for prime time? J Am Med Dir Assoc 2008;9:219–236.PubMedCrossRefGoogle Scholar
  93. 93.
    Argiles JM, Anker SD, Evans WJ, et al. Consensus on cachexia definitions. J Am Med Dir Assoc 2010;11:229–230.PubMedCrossRefGoogle Scholar
  94. 94.
    Kehayias JJ, Ribeiro SM, Skahan A, et al. Water homeostasis, frailty and cognitive function in the nursing home. J Nutr Health Aging 2012;16:35–39.PubMedCrossRefGoogle Scholar
  95. 95.
    Schols JM, De Groot CP, van der Cammen TJ, Olde Rikkert MG. Preventing and treating dehydration in the elderly during periods of illness and warm weather. J Nutr Health Aging 2009;13:150–157.PubMedCrossRefGoogle Scholar
  96. 96.
    Thomas DR, Cote TR, Lawhorne L, et al. Understanding clinical dehydration and its treatment. J Am Med Dir Assoc 2008;9:292–301.PubMedCrossRefGoogle Scholar
  97. 97.
    Inzitari M, Doets E, Bartali B, et al. Nutrition in the age-related disablement process. J Nutr Health Aging 2011;15:599–604.PubMedCrossRefGoogle Scholar
  98. 98.
    Tariq SH, Karcic E, Thomas DR, et al. The use of no-concentrated-sweets diet in the management of type 2 diabetes in nursing homes. J Am Diet Assoc 2001;101:1463–1466.PubMedCrossRefGoogle Scholar
  99. 99.
    Wilson MM, Purushothaman R, Morley JE. Effect of liquid dietary supplements on energy intake in the elderly. Am J Clin Nutr 2002;75:944–947.PubMedGoogle Scholar
  100. 100.
    van Wetering CR, Hoogendoorn M, Broekhuizen R, et al. Efficacy and costs of nutritional rehabilitation in muscle-wasted patients with chronic obstructive pulmonary disease in a community-based setting: A prespecified subgroup analysis of the INTERCOM trial. J Am Med Dir Assoc 2010;11:179–187.PubMedCrossRefGoogle Scholar
  101. 101.
    Mateen F, Jatol A. Megestrol acetate for the palliation of anorexia in advanced, incurable cancer patients. Clin Nutr 2006;25:711–715.PubMedCrossRefGoogle Scholar
  102. 102.
    Yeh SS, Lovitt S, Schuster MW. Usage of megestrol acetate in the treatment of anorexia-cachexia syndrome in the elderly. J Nutr Health Aging 2009;13:448–454.PubMedCrossRefGoogle Scholar
  103. 103.
    Wilson MM, Philpot C, Morley JE. Anorexia of aging in long term care: Is dronabinol an effective appetite stimulant—a pilot study. J Nutr Health Aging 2007;11:195–198.PubMedGoogle Scholar
  104. 104.
    Morley JE. End-of-life care in the nursing home. J Am Med Dir Assoc 2011;12:77–83.PubMedCrossRefGoogle Scholar
  105. 105.
    Chasen M, Hirschman SZ, Bhargava R. Phase II study of the novel peptide-nucleic acid OHR118 in the management of cancer-related anorexia/cachexia. J Am Med Dir Assoc 2011;12:62–67.PubMedCrossRefGoogle Scholar
  106. 106.
    Gaskin FS, Farr SA, Banks WA, Kumar VB, Morley JE. Ghrelin-induced feeding is dependent on nitric oxide. Peptides 2003;24:913–918.PubMedCrossRefGoogle Scholar
  107. 107.
    Yaxley A, Miller MD, Fraser RJ, Cobiac L. Pharmacological interventions for geriatric cachexia: A narrative review of the literature. J Nutr Health Aging 2012;16:148–154.PubMedCrossRefGoogle Scholar
  108. 108.
    Aparanji KP, Dharmarajan TS. Pause before a PEG: A feeding tube may not be necessary in every candidate! J Am Med Dir Assoc 2010;11:453–456.PubMedCrossRefGoogle Scholar
  109. 109.
    Kuo S, Rhodes RL, Mitchell SL, et al. Natural history of feeding-tube use in nursing home residents with advanced dementia. J Am Med Dir Assoc 2009;10:264–270.PubMedCrossRefGoogle Scholar
  110. 110.
    Gillick MR, Volandes AE. The standard of caring: Why do we still use feeding tubes in patients with advanced dementia? J Am Med Dir Assoc 2008;9:364–367.PubMedCrossRefGoogle Scholar
  111. 111.
    Biola H, Sloane PD, Williams CS, et al. Preferences versus practice: Life-sustaining treatments in last months of life in long-term care. J Am Med Dir Assoc 2010;11:42–51.PubMedCrossRefGoogle Scholar
  112. 112.
    Finucane TE, Christmas C, Leff BA. Tube feeding in dementia: How incentives undermine health care quality and patient safety. J Am Med Dir Assoc 2007;8:205–208.PubMedCrossRefGoogle Scholar
  113. 113.
    Tolson D, Rolland Y, Andrieu S, et al; The International Association of Gerontology and Geriatrics/World Health Organization/Society Française de Gérontologie et de Gériatrie Task Force. International Association of Gerontology and Geriatrics: A global agenda for clinical research and quality of care in nursing homes. J Am Med Dir Assoc 2011;12:184–189.PubMedCrossRefGoogle Scholar
  114. 114.
    Rolland Y, Aquino JP, Andrieu S, et al. Identification of the main domains for quality of care and clinical research in nursing homes. J Nutr Health Aging 2011;15:410–424.PubMedCrossRefGoogle Scholar

Copyright information

© Serdi and Springer Verlag France 2012

Authors and Affiliations

  1. 1.Division of Geriatric MedicineSaint Louis University School of MedicineSt. LouisUSA
  2. 2.Division of Geriatric MedicineSaint Louis University School of MedicineSt. LouisUSA

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