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The journal of nutrition, health & aging

, Volume 16, Issue 4, pp 383–388 | Cite as

Prospective observational study of isoflavone and the risk of stroke recurrence: Potential clinical implications beyond vascular function

  • Y. -H. Chan
  • K. -K. Lau
  • K. -H. Yiu
  • C. -W. Siu
  • H. -T. Chan
  • S. -W. Li
  • S. Tam
  • T. -H. Lam
  • C. -P. Lau
  • Hung-Fat TseEmail author
JNHA: Clinical Trials and Aging

Abstract

Background

Whether isoflavone has any effect on recurrent cardiovascular events is unknown.

Objective

To investigate the relations between isoflavone intake and the risk of stroke recurrence.

Subjects and Methods

We recruited 127 consecutive patients with prior history of atherothrombolic/ hemorrhagic stroke (mean age: 67 ± 11 years, 69% male) and prospectively followed up for a mean duration of 30 months. Stroke recurrence and major adverse cardiovascular events (MACE) were documented. Brachial flow-mediated dilatation (FMD) was measured using high-resolution ultrasound. Isoflavone intake was estimated using a validated food frequency questionnaire.

Results

Median isoflavone intake was 6.9 (range: 2.1–14.5) mg/day. Isoflavone intake was independently associated with increased FMD (Pearson R=0.23, p=0.012). At 30 months, there were 10 stroke recurrence and 12 MACE. Kaplan-Meier analysis showed that patients with isoflavone intake higher than median value had significantly longer median stroke recurrence-free survival time (19.0 [range: 10.4–27.6] mth versus 5.0 [range: 4.1–5.9] mth, p=0.021) and MACE-free survival time (19.0 [range: 10.4–27.6] mth versus 4.0 [range: 2.4–5.6] mth, p=0.013). Using multivariate cox regression, higher isoflavone intake was an independent predictor for lower risk of stroke recurrence (hazards ratio 0.18 [95%CI: 0.03–0.95], risk reduction 82%, p=0.043) and MACE (hazards ratio 0.16 [95%CI: 0.03–0.84], risk reduction 84%, p=0.030).

Conclusions

Higher isoflavone intake in stroke patients was associated with prolonged recurrence-free survival, and reduced risk of stroke recurrence and MACE, independent of baseline vascular.function. Whether isoflavone may confer clinically significant secondary protection in stroke patients should be further investigated in a randomized controlled trial.

Key words

Recurrent stroke isoflavone diet secondary prevention vascular function 

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Copyright information

© Serdi and Springer Verlag France 2012

Authors and Affiliations

  • Y. -H. Chan
    • 1
  • K. -K. Lau
    • 2
  • K. -H. Yiu
    • 2
  • C. -W. Siu
    • 2
  • H. -T. Chan
    • 2
  • S. -W. Li
    • 3
  • S. Tam
    • 4
  • T. -H. Lam
    • 1
  • C. -P. Lau
    • 2
  • Hung-Fat Tse
    • 2
    • 5
    Email author
  1. 1.School of Public HealthThe University of Hong KongHong KongChina
  2. 2.Cardiology Division, Department of MedicineThe University of Hong Kong, Queen Mary HospitalHong KongChina
  3. 3.Department of MedicineTung Wah HospitalHong KongChina
  4. 4.Department of Clinical Biochemistry UnitQueen Mary HospitalHong KongChina
  5. 5.Department of MedicineThe University of Hong Kong, Queen Mary HospitalHong KongChina

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