The journal of nutrition, health & aging

, Volume 16, Issue 3, pp 201–204 | Cite as

Changes in blood oxidative and antioxidant parameters in a group of Chinese patients with age-related macular degeneration

  • Xueli ShenEmail author
  • L. H. Jia
  • P. Zhao
  • R. Fan
  • X. Y. Pan
  • H. M. Yang
  • L. Liu
JNHA: Nutrition



To measure the oxidative and antioxidant biochemical parameters in the serum of Chinese patients with age-related macular degeneration (AMD) and in a similar age control group from the same area.


A case-control study.


56 AMD patients (21 early dry, 13 geographic atrophy and 22 wet form) and 34 normal subjects, similar for age and sex were studied.


Both groups completed a questionnaire about demographic characters and dieatry habit, and the levels of serum lipid peroxidation (malondialdehyde, MDA) and antioxidants parameters (vitamin C and E, the activities of superoxide dismutase-SOD, total antioxidant capacity — TAC) were determined.


There was a significantly higher frequency of daily intake of fruit and legumes in controls than in AMD patients. There was a significantly increased serum MDA levels and SOD activities, and significantly decreased serum vitamin C and total antioxidant capacity in AMD patients as compared to controls. The intensity of lipid peroxidation was higher with the progression of AMD. There was not difference in serum vitamin E levels between AMD patients and controls.


Oxido-reduction disturbance may be involved in the pathogenesis of AMD. There is a significantly decreased antioxidant capacity in AMD patients.

Key words

Antioxidant capacity malondialdehyde chinese age-related macular degeneration 


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Copyright information

© Serdi and Springer Verlag France 2012

Authors and Affiliations

  • Xueli Shen
    • 1
    Email author
  • L. H. Jia
    • 2
  • P. Zhao
    • 3
  • R. Fan
    • 3
  • X. Y. Pan
    • 2
  • H. M. Yang
    • 2
  • L. Liu
    • 2
  1. 1.Department of Neurology, The First Affiliated HospitalChina Medical UniversityShenyangChina
  2. 2.Department of Nutrition and Food hygiene, School of Public HealthChina Medical UniversityShenyangChina
  3. 3.Shenyang AIER Ophthalmology HospitalShenyangChina

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