Changes in blood oxidative and antioxidant parameters in a group of Chinese patients with age-related macular degeneration
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To measure the oxidative and antioxidant biochemical parameters in the serum of Chinese patients with age-related macular degeneration (AMD) and in a similar age control group from the same area.
A case-control study.
56 AMD patients (21 early dry, 13 geographic atrophy and 22 wet form) and 34 normal subjects, similar for age and sex were studied.
Both groups completed a questionnaire about demographic characters and dieatry habit, and the levels of serum lipid peroxidation (malondialdehyde, MDA) and antioxidants parameters (vitamin C and E, the activities of superoxide dismutase-SOD, total antioxidant capacity — TAC) were determined.
There was a significantly higher frequency of daily intake of fruit and legumes in controls than in AMD patients. There was a significantly increased serum MDA levels and SOD activities, and significantly decreased serum vitamin C and total antioxidant capacity in AMD patients as compared to controls. The intensity of lipid peroxidation was higher with the progression of AMD. There was not difference in serum vitamin E levels between AMD patients and controls.
Oxido-reduction disturbance may be involved in the pathogenesis of AMD. There is a significantly decreased antioxidant capacity in AMD patients.
Key wordsAntioxidant capacity malondialdehyde chinese age-related macular degeneration
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- 6.Wiktorowska-Owczarek A, Nowak JZ. Pathogenesis and prophylaxis of AMD: focus on oxidative stress and antioxidants. Postepy Hig Med Dosw 2010; 28: 333–343.Google Scholar
- 7.Age-Related Eye Disease Study Research Group. A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, betacarotene, and zinc for age-related macular degeneration and vision loss: AREDS Report No. 8. Arch Ophthalmol 2001; 119: 1417–1436.Google Scholar
- 11.Walter Willett, (1998) Nutritional Epidemioligy. Oxford University Press, Inc.Google Scholar
- 12.The Chinese Nutrition Society. Dietary guidelines and the food guide pagoda for Chinese residents: balanced diet, rational nutrition and health promotion. Nutr Today. 1999; 34: 106–115.Google Scholar