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The journal of nutrition, health & aging

, Volume 15, Issue 8, pp 690–694 | Cite as

Physical frailty predicts future cognitive decline — A four-year prospective study in 2737 cognitively normal older adults

  • T. W. Auyeung
  • J. S. W. Lee
  • T. Kwok
  • J. Woo
Physical Frailty Predicts Future Cognitive Declin

Abstract

Objective

To examine the association between baseline frailty measurements and cognitive function 4 years later.

Design

Prospective observational study.

Setting

Community.

Participants

Two thousand seven hundred and thirty seven cognitively normal older adults.

Measurement

The appendicular muscle mass (ASM), hand grip strength, timed chair-stand test, walking speed and step length were measured at baseline. The Minimental state examination (MMSe) was administered at baseline and 4 years later.

Results

In men, all baseline frailty measurements, namely, being underweight, lower ASM, weaker grip strength, slower chair-stand test, shorter step length, slower timed walk were significantly associated with a lower MMSe score 4 years afterwards. After adjustment for age, years of education and baseline MMSe score, ASM and timed walk became insignificant. In women, all frailty measurements except underweight and low ASM were significantly associated with MMSe score 4 years later. Moreover, only weaker grip strength persisted to be significant after adjustment for age, years of education and baseline MMSe score.

Conclusion

Physical frailty, as represented by being underweight, weaker grip strength, slower chair-stand test, shorter step-length in men and weaker grip strength in women, was associated with cognitive decline over a four year period.

Key words

Frailty physical function dementia cognitive impairment 

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Copyright information

© Serdi and Springer Verlag France 2011

Authors and Affiliations

  • T. W. Auyeung
    • 1
  • J. S. W. Lee
    • 2
  • T. Kwok
    • 2
  • J. Woo
    • 2
  1. 1.S.H. Ho Centre for Gerontology and GeriatricThe Chinese University of Hong Kong and Pok Oi HospitalHong KongChina
  2. 2.Division of Geriatrics, Department of Medicine and TherapeuticsThe Chinese University of Hong KongHong KongChina

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