The journal of nutrition, health & aging

, Volume 15, Issue 5, pp 404–409 | Cite as

Nutritional approach for inhibiting bone resorption in institutionalized elderly women with vitamin D insufficiency and high prevalence of fracture

  • Jean-Philippe Bonjour
  • V. Benoit
  • O. Pourchaire
  • B. Rousseau
  • J. -C. Souberbielle
Nutritional Intervention on Bone Resorption in Elderly Women

Abstract

Background

Nutritional approach to the deterioration of bone integrity and increased fracture risk appears to be particularly appropriate in elderly women living in nursing homes.

Objective

To investigate the beneficial effect of the consumption of soft plain cheese on bone resorption markers in institutionalized elderly women.

Design

Prospective, randomized crossover controlled study.

Setting

Six French nursing homes or other institutions for elderly.

Participants

Institutionalized women ≥ 65 years old with low vitamin D status and calcium intake below 700 mg/day.

Intervention

Consumption of soft plain cheese made of semi-skimmed milk which was fortified by both vitamin D3 (+ 1.25µg/100g) and milk extracted Ca, thus achieving a total Ca content of 151 mg/100g as compared to about 118 mg/100g for standard fresh cheese. Two servings were taken every day during the 6 weeks that preceded or followed a period of 6 weeks without soft plain cheese consumption.

Measurements

The primary end point was the change in serum carboxy terminal cross-linked telopeptide of type I collagen (CTX) selected as a marker of bone resorption.

Results

29 women aged 73–94 yr were selected, 21 of them with mean age 87.2±6.1 years remained compliant The intervention increased calcium and protein intakes by 51% (904±228 vs. 599±122 mg/d) and 33 % (74.2±17.1 vs. 55.6±12.7 g/d, mean±SD), respectively. The dietary intervention was associated with a statistically significant increase in serum levels of both 25OHD and IGF-I, while those of PTH, CTX and TRAP5b were significantly reduced. Compliance was 93,4 %. The daily consumption of two servings of soft plain cheese was well accepted in terms of tastiness and appetite suited portion size.

Conclusion

This randomized crossover controlled trial demonstrates that in elderly women living in nursing homes, the consumption of soft plain cheese increasing the supply of vitamin D, calcium and proteins, could reduce bone resorption and thereby reduce the risk of incidental fragility fractures in the long term.

Key words

Elderly women osteoporosis prevention nutritional intervention fortified cheese bone resorption 

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Copyright information

© Serdi and Springer Verlag France 2011

Authors and Affiliations

  • Jean-Philippe Bonjour
    • 2
    • 1
    • 6
  • V. Benoit
    • 3
    • 1
  • O. Pourchaire
    • 4
    • 1
  • B. Rousseau
    • 3
    • 1
  • J. -C. Souberbielle
    • 5
    • 1
  1. 1.University Hospitals and Faculty of MedicineGenevaSwitzerland
  2. 2.Division of Bone DiseasesWHO Collaborating Center for Osteoporosis PreventionGenevaSwitzerland
  3. 3.Groupe de Recherche Nutritionnelle, YoplaitBoulogneFrance
  4. 4.Hôpital Local Intercommunal de MorestelMorestelFrance
  5. 5.Laboratoire d’Explorations FonctionnellesHôpital Necker-Enfant MaladesParisFrance
  6. 6.Division of Bone DiseasesGeneva University Hospitals and Faculty of MedicineGeneva 14Switzerland

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