The journal of nutrition, health & aging

, Volume 15, Issue 3, pp 240–244 | Cite as

The correlation between the clinical laboratory data and the telomere length in peripheral blood leukocytes of Japanese female patients with hypertension

  • Toyoki Maeda
  • J. -I. Oyama
  • M. Sasaki
  • T. Arima
  • N. Makino
Clinical Laboratory Data, Telomere Length in Peripheral Blood Leukocytes

Abstract

Objective

This study investigated the correlation between the chronological age, telomere length in peripheral blood leukocytes and blood laboratory data of female patients with mild hypertension to identify laboratory data that reflect the biological aging of individuals.

Design

Cross-sectional population-based study.

Setting

Outpatient clinic of the Department of Cardiovascular, Respiratory, and Geriatric Medicine Kyushu University Hospital at Beppu in Japan.

Participants

Outpatients with mild hypertension treated with a low dose of amlodipine.

Measurements

The laboratory data of female patients were collected and the telomere length parameters in their peripheral blood leukocytes were determined by Southern blotting. Any correlations between the laboratory data and the telomere length parameters were assessed.

Results

The patients showed a positive correlation between the telomere length and the high density lipoprotein, albumin, creatinine, hemoglobin levels, red blood cell counts, and a negative correlation with the globulin level. The extent of subtelomeric methylation of long telomeres tended to correlate negatively with the telomeric attrition. Only the creatinine level correlated with subtelomeric methylation, but not with telomeric length.

Conclusion

HDL and the albumin/globulin ratio were potential indicators for individual somatic genomic aging. Creatinine may therefore be a useful indicator for a predisposition for telomeric attrition.

Key words

Telomere length subtelomeric methylation blood sugar level renal function arteriosclerosis 

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Copyright information

© Serdi and Springer Verlag France 2011

Authors and Affiliations

  • Toyoki Maeda
    • 1
  • J. -I. Oyama
    • 2
  • M. Sasaki
    • 1
  • T. Arima
    • 3
  • N. Makino
    • 1
  1. 1.The Division of Molecular and Clinical Gerontology, the Department of Molecular and Cellular Biology, Medical Institute of BioregulationKyushu UniversityOitaJapan
  2. 2.The Department of Cardiovascular, Respiratory, and Geriatric MedicineKyushu University Hospital at Beppu, Kyushu UniversityOitaJapan
  3. 3.Innovation of New Biomedical Engineering CenterTohoku University Graduate School of MedicineSendaiJapan

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