Vitamin B12 deficiency in African American and white octogenarians and centenarians in Georgia
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Test the hypotheses that vitamin B12 deficiency would be prevalent in octogenarians and centenarians and associated with age, gender, race/ethnicity, living arrangements (community or skilled nursing facility), animal food intake, B-vitamin supplement use, atrophic gastritis, folate status, and hematological indicators.
Population-based multi-ethnic sample of adults aged 80 to 89 and 98 and above.
Northern Georgia in the United States.
Men and women aged 80 to 89 (octogenarians, n = 80) and 98 and older (centenarians, n = 231).
Wilcoxon signed-rank tests, Fisher℉s exact tests, and logistic regression analysis was used to examine the associations of vitamin B12 status with the variables of interest.
After excluding participants receiving vitamin B12 injections (n = 17), the prevalence of vitamin B12 deficiency was higher in centenarians than in octogenarians (35.3% vs. 22.8%, p < 0.05, defined as plasma vitamin B12 < 258 pmol/L and serum methylmalonic acid > 271 nmol/L and methylmalonic acid > serum 2-methylcitrate) and in both age groups was correlated with significantly higher homocysteine (p < 0.05) and lower plasma and red cell folate (p < 0.01), but was not related to hemoglobin, anemia, mean cell volume, or macrocytosis. In logistic regression analysis, the probability of being vitamin B12-deficient was significantly increased by being a centenarian vs. octogenarian (p < 0.03), by being white vs. African American (p < 0.02), by increasing severity of atrophic gastritis (p < 0.001), and by not taking oral B-vitamin supplements (p < 0.01), but was not related to gender, living arrangements, or animal food intake.
Centenarians and octogenarians are at high risk for vitamin B12 deficiency for many of the same reasons identified in other older adult populations. Given the numerous potential adverse consequences of poor vitamin B12 status, efforts are needed to ensure vitamin B12 adequacy in these older adults.
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- 1.Poon LW, Jazwinski SM, Green RC, Woodard JL, Martin P, Rodgers WL, Johnson MA, Hausman DB, Arnold J, et al. Methodological considerations in studying centenarians: lessons learned from the Georgia centenarian studies. Ann Rev Gerontology and Geriatrics 2007;27:213–264.Google Scholar
- 4.Basile G, Gangemi S, Lo Balbo C, Mento A, Nicita-Mauro C, Crisafulli G, Merendino RA, Ientile R, Nicita-Mauro V. Correlation between serum retinol and alpha-tocopherol levels in centenarians. J Nutr Sci Vitaminol (Tokyo) 2003;49:287–288.Google Scholar
- 12.Institute of Medicine. Dietary Reference Intakes for Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline. Food and Nutrition Board. National Academy of Sciences. 1998. Washington DC: National Academy Press.Google Scholar
- 31.World Health Organization. Iron deficiency anaemia — Assessment, prevention, and control. A guide for programme managers. Geneva: World Health Organization, 2001. Internet: http://www.who.int/nutrition/publications/micronutrients/anaemia_iron_deficiency/en/ida_assessment_prevention_control.pdf (accessed November 1, 2008).Google Scholar