Short-term influence of elevation of plasma homocysteine levels on cognitive function in young healthy adults
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Acute homocysteine elevation has been shown to have a significant impact on cognitive function in animal models.
Investigation of the short-term impact of elevation of plasma homocysteine levels through a dietary intervention on cognitive abilities of young healthy adults.
100 healthy medical students of both genders were enrolled in the study.
Design and Measurements
Homocysteine levels and cognitive abilities were measured at 08:30 (before breakfast) and at 15:00 (two hours after lunch and six hours after breakfast). Food intake was restricted to specified comestibles. The cognitive assessment comprised a version of the Short Test for General Intelligence, three subtests of the Syndrome Short Test and the Stroop test.
At 15:00 plasma homocysteine was significantly elevated in 56 participants (P<0.00001), whilst in 44 it was decreased (P<0.00001) in comparison to baseline (08:30). The decrease was however of limited clinical significance. The differences in the changes in cognitive performance between the two groups did not attain statistical significance (P>0.05) and the direction of the changes did not differ between them. Accordingly, the multiple linear regression analysis did not reveal an important influence of homocysteine elevation on cognitive performance variations.
Significant increase of plasma homocysteine is not associated with a straightforward inhibitory or facilitatory short-term effect on physiological cognitive parameters in young healthy adults.
Key wordsHomocysteine healthy adults cognitive function
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- 3.Selhub J, Bagley LC, Miller J, Rosenberg IH. B vitamins, homocysteine, and neurocognitive function in the elderly. Am J Clin Nutr. 2000;71:614–620.Google Scholar
- 9.Regland B, Abrahamsson L, Gottfries CG, Magnus E. Vitamin B12 analogues, homocysteine, methylmalonic acid, and transcobalamins in the study of vitamin B12 deficiency in primary degenerative dementia. Dementia 1990;1:272–277.Google Scholar
- 13.Wilhelm J, Bayerlein K, Hillemacher T, Reulbach U, Frieling H, Kromolan B, Degner D, Kornhuber J, Bleich S. Short-term cognition deficits during early alcohol withdrawal are associated with elevated plasma homocysteine levels in patients with alcoholism. J Neural Transm. 2006;113:357–363.PubMedCrossRefGoogle Scholar
- 18.White AR, Huang X, Jobling MF, Barrow CJ, Beyreuther K, Masters CL, Bush AI, Cappai R. Homocysteine potentiates copper- and amyloid beta peptide-mediated toxicity in primary neuronal cultures: possible risk factors in the Alzheimer’s-type neurodegenerative pathways. J Neurochem. 2001;76:1509–1520.PubMedCrossRefGoogle Scholar
- 25.Lehrl S, Gallwitz A, Blaha L, Fischer B: Geistige Leistungsfähigkeit. Theorie und Messung der biologischen Intelligenz mit dem Kurztest KAI, ed 3 Ebersberg, Vless, 1992.Google Scholar
- 29.Erzigkeit H: The SKT- A short cognitive performance test as an instrument for the assessment of clinical efficacy of cognitive enhancers; in Bergner W, Reisberg B (eds): Diagnosis and Treatment of Senile Dementia. Heidelberg, Springer Verlag, 1989.Google Scholar
- 30.Haider M: Elektrophysiologische Indikatoren der Aktivierung; in Schönpflug W (eds): Methoden der Aktivierungsforschung. Stuttgart, Huber, 1969.Google Scholar