Evolution of Aβ42 and Aβ40 levels and Aβ42/Aβ40 ratio in plasma during progression of Alzheimer’s disease: A multicenter assessment
- 216 Downloads
To better understand the seemingly contradictory plasma β-amyloid (Aβ) results in Alzheimer’s disease (AD) patients by using a newly developed plasma Aβ assay, the INNO-BIA plasma Aβ forms, in a multicenter study.
A combined retrospective analysis of plasma Aβ isoforms on mild cognitive impairment (MCI) from three large cross-sectional studies involving 643 samples from the participating German and Swedish centers.
Detection modules based on two different amino (N)-terminal specific Aβ monoclonal antibodies demonstrated that Aβ in plasma could be reliable quantified using a sandwich immunoassay technology with high precision, even for low Aβ42 plasma concentrations. Aβ40 and Aβ42 concentrations varied consistently with the ApoE genotype, while the Aβ42/Aβ40 ratio did not. Irrespective of the decrease of the Aβ42/Aβ40 ratio with age and MMSE, this parameter was strongly associated with AD, as defined in this study by elevated hyperphosphorylated (P-tau181P) levels in cerebrospinal fluid (CSF).
A highly robust assay for repeatedly measuring Aβ forms in plasma such as INNO-BIA plasma Aβ forms might be a useful tool in a future risk assessment of AD.
KeywordsMild Cognitive Impairment ApoE Genotype Mild Cognitive Impairment Patient Neurobiol Aging Medial Temporal Lobe Atrophy
Unable to display preview. Download preview PDF.
- 8.Ertekin-Taner N, Younkin LH, Yager DM, Parfitt F, Baker MC, Asthana S et al. Plasma amyloid ta protein is elevated in late-onset Alzheimer disease families. Neurology 2008; 70(8):596–606.Google Scholar
- 10.Hansson O, Zetterberg H, Vanmechelen E, Vanderstichele H, Andreasson U, Londos E et al. Evaluation of plasma Abeta(40) and Abeta(42) as predictors of conversion to Alzheimer’s disease in patients with mild cognitive impairment. Neurobiol Aging 2008; in press.Google Scholar
- 11.Kornhuber J, Schmidtke K, Frolich L, Perneczky R, Wolf S, Hampel H et al. Early and differential diagnosis of dementia and MCI: design and cohort baseline characteristics of the German Competence Net Dementias. Dementia Geriatr. Cogn. Disorders in press.Google Scholar