Sleep disorders and their impacts on healthy, dependent, and frail older adults

  • Valérie Cochen
  • C. Arbus
  • M. E. Soto
  • H. Villars
  • M. Tiberge
  • T. Montemayor
  • C. Hein
  • M. F. Veccherini
  • S. -H. Onen
  • I. Ghorayeb
  • M. Verny
  • L. J. Fitten
  • J. Savage
  • Y. Dauvilliers
  • B. Vellas
Sleep Disorders and Their Impacts on Healthy, Dependent, and Frail Older Adults

Abstract

Background

Sleep disorders differ widely in the heterogeneous older adult population. Older adults can be classified into three groups based upon their overall level of disability: healthy, dependent, and frail. Frailty is an emerging concept that denotes older persons at increased risk for poor outcomes.

Objective

The aim of this consensus review is to describe the sleep disorders observed in healthy and dependent older adults and to discuss the potential sleep disorders associated with frailty as well as their potential consequences on this weakened population.

Methods

A review task force was created including neurologists, geriatricians, sleep specialists and geriatric psychiatrists to discuss age related sleep disorders depending on the three categories of older adults. All published studies on sleep in older adults on Ovid Medline were reviewed and 106 articles were selected for the purpose of this consensus.

Results

Many healthy older adults have complains about their sleep such as waking not rested and too early, trouble falling asleep, daytime napping, and multiple nocturnal awakenings. Sleep architecture is modified by age with an increased percentage of time spent in stage one and a decreased percentage spent in stages three and four. Insomnia is frequent and its mechanisms include painful medical conditions, psychological distress, loss of physical activity and iatrogenic influences. Treatments are also involved in older adults’ somnolence. The prevalence of primary sleep disorders such as restless legs syndrome, periodic limb movements and sleep disordered breathing increases with age. Potential outcomes relevant to these sleep disorders in old age include mortality, cardiovascular and neurobehavioral co-morbidities. Sleep in dependent older adults such as patients with Alzheimer Disease (AD) is disturbed. The sleep patterns observed in these patients are often similar to those observed in non-demented elderly but alterations are more severe. Nocturnal sleep disruption and daytime sleepiness are the main problems. They are the results of Sleep/wake circadian rhythm disorders, environmental, psychological and iatrogenic factors. They are worsened by other sleep disorders such as sleep disordered breathing. Sleep in frail older adults per se has not yet been formally studied but four axes of investigation should be considered: i) sleep architecture abnormalities, ii) insomnia iii) restless legs syndrome (RLS), iv) sleep disordered breathing.

Conclusion

Our knowledge in the field of sleep disorders in older adults has increased in recent years, yet some groups within this heterogeneous population, such as frail older adults, remain to be more thoroughly studied and characterized.

Key words

Sleep disorders healthy dependent frailty older adults 

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References

  1. 1.
    Morley JE, Baumgartner RN, Roubenoff R, Mayer J, Nair KS. Sarcopenia. J Lab Clin Med 2001;137(4):231–243.PubMedCrossRefGoogle Scholar
  2. 2.
    Vellas B, Gillette-Guyonnet S, Nourhashemi F, Rolland Y, Lauque S, Ousset PJ, et al. [Falls, frailty and osteoporosis in the elderly: a public health problem]. Rev Med Interne 2000;21(7):608–613.PubMedCrossRefGoogle Scholar
  3. 3.
    Abellan van Kan G, Rolland Y, Bergman H, Morley JE, Kritchevsky SB, Vellas B. The I.A.N.A Task Force on frailty assessment of older people in clinical practice. J Nutr Health Aging 2008;12(1):29–37.PubMedCrossRefGoogle Scholar
  4. 4.
    Lipsitz LA. Dynamics of stability: the physiologic basis of functional health and frailty. J Gerontol A Biol Sci Med Sci 2002;57(3):B115–B125.PubMedGoogle Scholar
  5. 5.
    Fried LP, Ferrucci L, Darer J, Williamson JD, Anderson G. Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care. J Gerontol A Biol Sci Med Sci 2004;59(3):255–263.PubMedGoogle Scholar
  6. 6.
    Bortz WM, 2nd. A conceptual framework of frailty: a review. J Gerontol A Biol Sci Med Sci 2002;57(5):M283–M288.PubMedGoogle Scholar
  7. 7.
    Studenski S, Hayes RP, Leibowitz RQ, Bode R, Lavery L, Walston J, et al. Clinical Global Impression of Change in Physical Frailty: development of a measure based on clinical judgment. J Am Geriatr Soc 2004;52(9):1560–1566.PubMedCrossRefGoogle Scholar
  8. 8.
    Rockwood K, Song X, MacKnight C, Bergman H, Hogan DB, McDowell I, et al. A global clinical measure of fitness and frailty in elderly people. Cmaj 2005;173(5):489–495.PubMedGoogle Scholar
  9. 9.
    Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci 2001;56(3):M146–M156.PubMedGoogle Scholar
  10. 10.
    Gill TM, Gahbauer EA, Allore HG, Han L. Transitions between frailty states among community-living older persons. Arch Intern Med 2006;166(4):418–423.PubMedCrossRefGoogle Scholar
  11. 11.
    Bliwise DL. Sleep in normal aging and dementia. Sleep 1993;16(1):40–81.PubMedGoogle Scholar
  12. 12.
    Dijk DJ, Duffy JF, Riel E, Shanahan TL, Czeisler CA. Ageing and the circadian and homeostatic regulation of human sleep during forced desynchrony of rest, melatonin and temperature rhythms. J Physiol 1999;516(Pt 2):611–627.PubMedCrossRefGoogle Scholar
  13. 13.
    Redline S, Kirchner HL, Quan SF, Gottlieb DJ, Kapur V, Newman A. The effects of age, sex, ethnicity, and sleep-disordered breathing on sleep architecture. Arch Intern Med 2004;164(4):406–418.PubMedCrossRefGoogle Scholar
  14. 14.
    Crowley K, Trinder J, Kim Y, Carrington M, Colrain IM. The effects of normal aging on sleep spindle and K-complex production. Clin Neurophysiol 2002;113(10):1615–1622.PubMedCrossRefGoogle Scholar
  15. 15.
    Wauquier A. Aging and changes in phasic events during sleep. Physiol Behav 1993;54(4):803–806.PubMedCrossRefGoogle Scholar
  16. 16.
    Darchia N, Campbell IG, Feinberg I. Rapid eye movement density is reduced in the normal elderly. Sleep 2003;26(8):973–977.PubMedGoogle Scholar
  17. 17.
    Van Cauter E, Leproult R, Plat L. Age-related changes in slow wave sleep and REM sleep and relationship with growth hormone and cortisol levels in healthy men. Jama 2000;284(7):861–868.PubMedCrossRefGoogle Scholar
  18. 18.
    Blackman MR. Age-related alterations in sleep quality and neuroendocrine function: interrelationships and implications. Jama 2000;284(7):879–881.PubMedCrossRefGoogle Scholar
  19. 19.
    Vgontzas AN, Zoumakis M, Bixler EO, Lin HM, Prolo P, Vela-Bueno A, et al. Impaired nighttime sleep in healthy old versus young adults is associated with elevated plasma interleukin-6 and cortisol levels: physiologic and therapeutic implications. J Clin Endocrinol Metab 2003;88(5):2087–2095.PubMedCrossRefGoogle Scholar
  20. 20.
    Ancoli-Israel S, Kripke DF, Klauber MR, Mason WJ, Fell R, Kaplan O. Periodic limb movements in sleep in community-dwelling elderly. Sleep 1991;14(6):496–500.PubMedGoogle Scholar
  21. 21.
    Bliwise D. Normal aging. In: Kryger MH RT, Dement WC, editor. Principles and Practice of Sleep Medicine, 4rd ed. Philadelphia: Saunders; 2005. p. 26–42.Google Scholar
  22. 22.
    O’Keeffe ST, Gavin K, Lavan JN. Iron status and restless legs syndrome in the elderly. Age Ageing 1994;23(3):200–203.PubMedCrossRefGoogle Scholar
  23. 23.
    Cervenka S, Palhagen SE, Comley RA, Panagiotidis G, Cselenyi Z, Matthews JC, et al. Support for dopaminergic hypoactivity in restless legs syndrome: a PET study on D2-receptor binding. Brain 2006;129(Pt 8):2017–2028.PubMedCrossRefGoogle Scholar
  24. 24.
    Winkelmann J, Schormair B, Lichtner P, Ripke S, Xiong L, Jalilzadeh S, et al. Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions. Nat Genet 2007;39(8):1000–1006.PubMedCrossRefGoogle Scholar
  25. 25.
    Stefansson H, Rye DB, Hicks A, Petursson H, Ingason A, Thorgeirsson TE, et al. A genetic risk factor for periodic limb movements in sleep. N Engl J Med 2007;357(7):639–647.PubMedCrossRefGoogle Scholar
  26. 26.
    Siddiqui F, Strus J, Ming X, Lee IA, Chokroverty S, Walters AS. Rise of blood pressure with periodic limb movements in sleep and wakefulness. Clin Neurophysiol 2007;118(9):1923–1930.PubMedCrossRefGoogle Scholar
  27. 27.
    Pennestri MH, Montplaisir J, Colombo R, Lavigne G, Lanfranchi PA. Nocturnal blood pressure changes in patients with restless legs syndrome. Neurology 2007;68(15):1213–1218.PubMedCrossRefGoogle Scholar
  28. 28.
    Foley DJ, Monjan AA, Brown SL, Simonsick EM, Wallace RB, Blazer DG. Sleep complaints among elderly persons: an epidemiologic study of three communities. Sleep 1995;18(6):425–432.PubMedGoogle Scholar
  29. 29.
    Ancoli-Israel S. Sleep and aging: prevalence of disturbed sleep and treatment considerations in older adults. J Clin Psychiatry 2005;66Suppl 9:24–30; quiz 42–3.PubMedGoogle Scholar
  30. 30.
    Czeisler CA, Dumont M, Duffy JF, Steinberg JD, Richardson GS, Brown EN, et al. Association of sleep-wake habits in older people with changes in output of circadian pacemaker. Lancet 1992;340(8825):933–936.PubMedCrossRefGoogle Scholar
  31. 31.
    Munch M, Knoblauch V, Blatter K, Schroder C, Schnitzler C, Krauchi K, et al. Agerelated attenuation of the evening circadian arousal signal in humans. Neurobiol Aging 2005;26(9):1307–1319.PubMedCrossRefGoogle Scholar
  32. 32.
    Tsuno N, Jaussent I, Dauvilliers Y, Touchon J, Ritchie K, Besset A. Determinants of excessive daytime sleepiness in a French community-dwelling elderly population. J Sleep Res 2007;16(4):364–371.PubMedCrossRefGoogle Scholar
  33. 33.
    Vitiello MV, Moe KE, Prinz PN. Sleep complaints cosegregate with illness in older adults: clinical research informed by and informing epidemiological studies of sleep. J Psychosom Res 2002;53(1):555–559.PubMedCrossRefGoogle Scholar
  34. 34.
    Morgan K. Daytime activity and risk factors for late-life insomnia. J Sleep Res 2003;12(3):231–238.PubMedCrossRefGoogle Scholar
  35. 35.
    Stone KL, Ancoli-Israel S, Blackwell T, Ensrud KE, Cauley JA, Redline S, et al. Actigraphy-measured sleep characteristics and risk of falls in older women. Arch Intern Med 2008;168(16):1768–1775.PubMedCrossRefGoogle Scholar
  36. 36.
    Merrill RM, Aldana SG, Greenlaw RL, Diehl HA, Salberg A. The effects of an intensive lifestyle modification program on sleep and stress disorders. J Nutr Health Aging 2007;11(3):242–248.PubMedGoogle Scholar
  37. 37.
    Soeffing JP, Lichstein KL, Nau SD, McCrae CS, Wilson NM, Aguillard RN, et al. Psychological treatment of insomnia in hypnotic-dependant older adults. Sleep Med 2008;9(2):165–171.PubMedCrossRefGoogle Scholar
  38. 38.
    Garfinkel D, Laudon M, Nof D, Zisapel N. Improvement of sleep quality in elderly people by controlled-release melatonin. Lancet 1995;346(8974):541–544.PubMedCrossRefGoogle Scholar
  39. 39.
    Haimov I, Laudon M, Zisapel N, Souroujon M, Nof D, Shlitner A, et al. Sleep disorders and melatonin rhythms in elderly people. Bmj 1994;309(6948):167.PubMedGoogle Scholar
  40. 40.
    Phillips B, Young T, Finn L, Asher K, Hening WA, Purvis C. Epidemiology of restless legs symptoms in adults. Arch Intern Med 2000;160(14):2137–2141.PubMedCrossRefGoogle Scholar
  41. 41.
    Tison F, Crochard A, Leger D, Bouee S, Lainey E, El Hasnaoui A. Epidemiology of restless legs syndrome in French adults: a nationwide survey: the INSTANT Study. Neurology 2005;65(2):239–246.PubMedCrossRefGoogle Scholar
  42. 42.
    Ghorayeb I, Bioulac B, Scribans C, Tison F. Perceived severity of restless legs syndrome across the female life cycle. Sleep Med 2007.Google Scholar
  43. 43.
    Ancoli-Israel S, Mason W, Coy TV, Stepnowsky C, Clausen JL, Dimsdale J. Evaluation of sleep disordered breathing with unattended recording: the Nightwatch System. J Med Eng Technol 1997;21(1):10–14.PubMedCrossRefGoogle Scholar
  44. 44.
    Naifeh KH, Severinghaus JW, Kamiya J. Effect of aging on sleep-related changes in respiratory variables. Sleep 1987;10(2):160–171.PubMedGoogle Scholar
  45. 45.
    Young T, Shahar E, Nieto FJ, Redline S, Newman AB, Gottlieb DJ, et al. Predictors of sleep-disordered breathing in community-dwelling adults: the Sleep Heart Health Study. Arch Intern Med 2002;162(8):893–900.PubMedCrossRefGoogle Scholar
  46. 46.
    Bixler EO, Vgontzas AN, Lin HM, Ten Have T, Rein J, Vela-Bueno A, et al. Prevalence of sleep-disordered breathing in women: effects of gender. Am J Respir Crit Care Med 2001;163(3 Pt 1):608–613.PubMedGoogle Scholar
  47. 47.
    Young T, Finn L, Austin D, Peterson A. Menopausal status and sleep-disordered breathing in the Wisconsin Sleep Cohort Study. Am J Respir Crit Care Med 2003;167(9):1181–1185.PubMedCrossRefGoogle Scholar
  48. 48.
    Tishler PV, Larkin EK, Schluchter MD, Redline S. Incidence of sleep-disordered breathing in an urban adult population: the relative importance of risk factors in the development of sleep-disordered breathing. Jama 2003;289(17):2230–2237.PubMedCrossRefGoogle Scholar
  49. 49.
    Martin SE, Mathur R, Marshall I, Douglas NJ. The effect of age, sex, obesity and posture on upper airway size. Eur Respir J 1997;10(9):2087–2090.PubMedCrossRefGoogle Scholar
  50. 50.
    Crow HC, Ship JA. Tongue strength and endurance in different aged individuals. J Gerontol A Biol Sci Med Sci 1996;51(5):M247–M250.PubMedGoogle Scholar
  51. 51.
    Endeshaw YW, Katz S, Ouslander JG, Bliwise DL. Association of denture use with sleep-disordered breathing among older adults. J Public Health Dent 2004;64(3):181–183.PubMedCrossRefGoogle Scholar
  52. 52.
    Pack AI, Silage DA, Millman RP, Knight H, Shore ET, Chung DC. Spectral analysis of ventilation in elderly subjects awake and asleep. J Appl Physiol 1988;64(3):1257–1267.PubMedGoogle Scholar
  53. 53.
    Ware JC, McBrayer RH, Scott JA. Influence of sex and age on duration and frequency of sleep apnea events. Sleep 2000;23(2):165–170.PubMedGoogle Scholar
  54. 54.
    Haimov I, Hadad BS, Shurkin D. Visual cognitive function: changes associated with chronic insomnia in older adults. J Gerontol Nurs 2007;33(10):32–41.PubMedGoogle Scholar
  55. 55.
    Kripke DF, Garfinkel L, Wingard DL, Klauber MR, Marler MR. Mortality associated with sleep duration and insomnia. Arch Gen Psychiatry 2002;59(2):131–136.PubMedCrossRefGoogle Scholar
  56. 56.
    Tamakoshi A, Ohno Y. Self-reported sleep duration as a predictor of all-cause mortality: results from the JACC study, Japan. Sleep 2004;27(1):51–54.PubMedGoogle Scholar
  57. 57.
    Montplaisir J, Petit D, Lorrain D, Gauthier S, Nielsen T. Sleep in Alzheimer’s disease: further considerations on the role of brainstem and forebrain cholinergic populations in sleep-wake mechanisms. Sleep 1995;18(3):145–148.PubMedGoogle Scholar
  58. 58.
    Petit D, Gagnon JF, Fantini ML, Ferini-Strambi L, Montplaisir J. Sleep and quantitative EEG in neurodegenerative disorders. J Psychosom Res 2004;56(5):487–496.PubMedCrossRefGoogle Scholar
  59. 59.
    Petit D, Montplaisir J, Lorrain D, Gauthier S. Spectral analysis of the rapid eye movement sleep electroencephalogram in right and left temporal regions: a biological marker of Alzheimer’s disease. Ann Neurol 1992;32(2):172–176.PubMedCrossRefGoogle Scholar
  60. 60.
    Bliwise DL. Sleep disorders in Alzheimer’s disease and other dementias. Clin Cornerstone 2004;6Suppl 1A:S16–S28.PubMedCrossRefGoogle Scholar
  61. 61.
    Ancoli-Israel S, Clopton P, Klauber MR, Fell R, Mason W. Use of wrist activity for monitoring sleep/wake in demented nursing-home patients. Sleep 1997;20(1):24–27.PubMedGoogle Scholar
  62. 62.
    Campbell SS, Kripke DF, Gillin JC, Hrubovcak JC. Exposure to light in healthy elderly subjects and Alzheimer’s patients. Physiol Behav 1988;42(2):141–144.PubMedCrossRefGoogle Scholar
  63. 63.
    Martin JL, Webber AP, Alam T, Harker JO, Josephson KR, Alessi CA. Daytime sleeping, sleep disturbance, and circadian rhythms in the nursing home. Am J Geriatr Psychiatry 2006;14(2):121–129.PubMedCrossRefGoogle Scholar
  64. 64.
    Yesavage JA, Friedman L, Ancoli-Israel S, Bliwise D, Singer C, Vitiello MV, et al. Development of diagnostic criteria for defining sleep disturbance in Alzheimer’s disease. J Geriatr Psychiatry Neurol 2003;16(3):131–139.PubMedCrossRefGoogle Scholar
  65. 65.
    Swaab DF, Fisser B, Kamphorst W, Troost D. The human suprachiasmatic nucleus; neuropeptide changes in senium and Alzheimer’s disease. Basic Appl Histochem 1988;32(1):43–54.PubMedGoogle Scholar
  66. 66.
    Harper DG, Volicer L, Stopa EG, McKee AC, Nitta M, Satlin A. Disturbance of endogenous circadian rhythm in aging and Alzheimer disease. Am J Geriatr Psychiatry 2005;13(5):359–368.PubMedGoogle Scholar
  67. 67.
    Sullivan SC, Richards KC. Predictors of circadian sleep-wake rhythm maintenance in elders with dementia. Aging Ment Health 2004;8(2):143–152.PubMedCrossRefGoogle Scholar
  68. 68.
    Skene DJ, Swaab DF. Melatonin rhythmicity: effect of age and Alzheimer’s disease. Exp Gerontol 2003;38(1–2):199–206.PubMedCrossRefGoogle Scholar
  69. 69.
    Giubilei F, Patacchioli FR, Antonini G, Sepe Monti M, Tisei P, Bastianello S, et al. Altered circadian cortisol secretion in Alzheimer’s disease: clinical and neuroradiological aspects. J Neurosci Res 2001;66(2):262–265.PubMedCrossRefGoogle Scholar
  70. 70.
    Volicer L, Harper DG, Manning BC, Goldstein R, Satlin A. Sundowning and circadian rhythms in Alzheimer’s disease. Am J Psychiatry 2001;158(5):704–711.PubMedCrossRefGoogle Scholar
  71. 71.
    Martin J, Marler M, Shochat T, Ancoli-Israel S. Circadian rhythms of agitation in institutionalized patients with Alzheimer’s disease. Chronobiol Int 2000;17(3):405–418.PubMedCrossRefGoogle Scholar
  72. 72.
    Wu YH, Swaab DF. The human pineal gland and melatonin in aging and Alzheimer’s disease. J Pineal Res 2005;38(3):145–152.PubMedCrossRefGoogle Scholar
  73. 73.
    Zhou JN, Liu RY, Kamphorst W, Hofman MA, Swaab DF. Early neuropathological Alzheimer’s changes in aged individuals are accompanied by decreased cerebrospinal fluid melatonin levels. J Pineal Res 2003;35(2):125–130.PubMedCrossRefGoogle Scholar
  74. 74.
    Asayama K, Yamadera H, Ito T, Suzuki H, Kudo Y, Endo S. Double blind study of melatonin effects on the sleep-wake rhythm, cognitive and non-cognitive functions in Alzheimer type dementia. J Nippon Med Sch 2003;70(4):334–341.PubMedCrossRefGoogle Scholar
  75. 75.
    Cardinali DP, Brusco LI, Liberczuk C, Furio AM. The use of melatonin in Alzheimer’s disease. Neuro Endocrinol Lett 2002;23Suppl 1:20–23.PubMedGoogle Scholar
  76. 76.
    Singer C, Tractenberg RE, Kaye J, Schafer K, Gamst A, Grundman M, et al. A multicenter, placebo-controlled trial of melatonin for sleep disturbance in Alzheimer’s disease. Sleep 2003;26(7):893–901.PubMedGoogle Scholar
  77. 77.
    Serfaty M, Kennell-Webb S, Warner J, Blizard R, Raven P. Double blind randomised placebo controlled trial of low dose melatonin for sleep disorders in dementia. Int J Geriatr Psychiatry 2002;17(12):1120–1127.PubMedCrossRefGoogle Scholar
  78. 78.
    Riemersma-van der Lek RF, Swaab DF, Twisk J, Hol EM, Hoogendijk WJ, Van Someren EJ. Effect of bright light and melatonin on cognitive and noncognitive function in elderly residents of group care facilities: a randomized controlled trial. Jama 2008;299(22):2642–2655.PubMedCrossRefGoogle Scholar
  79. 79.
    Dowling GA, Burr RL, Van Someren EJ, Hubbard EM, Luxenberg JS, Mastick J, et al. Melatonin and bright-light treatment for rest-activity disruption in institutionalized patients with Alzheimer’s disease. J Am Geriatr Soc 2008;56(2):239–246.PubMedCrossRefGoogle Scholar
  80. 80.
    Bonanni E, Maestri M, Tognoni G, Fabbrini M, Nucciarone B, Manca ML, et al. Daytime sleepiness in mild and moderate Alzheimer’s disease and its relationship with cognitive impairment. J Sleep Res 2005;14(3):311–317.PubMedCrossRefGoogle Scholar
  81. 81.
    Lee JH, Bliwise DL, Ansari FP, Goldstein FC, Cellar JS, Lah JJ, et al. Daytime sleepiness and functional impairment in Alzheimer disease. Am J Geriatr Psychiatry 2007;15(7):620–626.PubMedCrossRefGoogle Scholar
  82. 82.
    Moran M, Lynch CA, Walsh C, Coen R, Coakley D, Lawlor BA. Sleep disturbance in mild to moderate Alzheimer’s disease. Sleep Med 2005;6(4):347–352.PubMedCrossRefGoogle Scholar
  83. 83.
    McCurry SM, Logsdon RG, Teri L, Gibbons LE, Kukull WA, Bowen JD, et al. Characteristics of sleep disturbance in community-dwelling Alzheimer’s disease patients. J Geriatr Psychiatry Neurol 1999;12(2):53–59.PubMedCrossRefGoogle Scholar
  84. 84.
    Jackson S, Ham RJ, Wilkinson D. The safety and tolerability of donepezil in patients with Alzheimer’s disease. Br J Clin Pharmacol 2004;58Suppl 1:1–8.PubMedCrossRefGoogle Scholar
  85. 85.
    Donaldson C, Tarrier N, Burns A. Determinants of carer stress in Alzheimer’s disease. Int J Geriatr Psychiatry 1998;13(4):248–256.PubMedCrossRefGoogle Scholar
  86. 86.
    Vitiello MV, Bliwise DL, Prinz PN. Sleep in Alzheimer’s disease and the sundown syndrome. Neurology 1992;42(7 Suppl 6):83–93; discussion 93–4.PubMedGoogle Scholar
  87. 87.
    Motohashi Y, Maeda A, Yuasa T, Higuchi S. Reliability and validity of the questionnaire to determine the biosocial rhythms of daily living in the disabled elderly. J Physiol Anthropol Appl Human Sci 2000;19(6):263–269.PubMedCrossRefGoogle Scholar
  88. 88.
    McCurry SM, Reynolds CF, Ancoli-Israel S, Teri L, Vitiello MV. Treatment of sleep disturbance in Alzheimer’s disease. Sleep Med Rev 2000;4(6):603–628.PubMedCrossRefGoogle Scholar
  89. 89.
    Gill TM, Baker DI, Gottschalk M, Gahbauer EA, Charpentier PA, de Regt PT, et al. A prehabilitation program for physically frail community-living older persons. Arch Phys Med Rehabil 2003;84(3):394–404.PubMedCrossRefGoogle Scholar
  90. 90.
    Chong MS, Ayalon L, Marler M, Loredo JS, Corey-Bloom J, Palmer BW, et al. Continuous positive airway pressure reduces subjective daytime sleepiness in patients with mild to moderate Alzheimer’s disease with sleep disordered breathing. J Am Geriatr Soc 2006;54(5):777–781.PubMedCrossRefGoogle Scholar
  91. 91.
    Martin JL, Ancoli-Israel S. Sleep disturbances in long-term care. Clin Geriatr Med 2008;24(1):39–50, vi.PubMedCrossRefGoogle Scholar
  92. 92.
    Gehrman PR, Martin JL, Shochat T, Nolan S, Corey-Bloom J, Ancoli-Israel S. Sleepdisordered breathing and agitation in institutionalized adults with Alzheimer disease. Am J Geriatr Psychiatry 2003;11(4):426–433.PubMedGoogle Scholar
  93. 93.
    Ayalon L, Ancoli-Israel S, Stepnowsky C, Marler M, Palmer BW, Liu L, et al. Adherence to continuous positive airway pressure treatment in patients with Alzheimer’s disease and obstructive sleep apnea. Am J Geriatr Psychiatry 2006;14(2):176–80.PubMedCrossRefGoogle Scholar
  94. 94.
    Moraes W, Poyares D, Sukys-Claudino L, Guilleminault C, Tufik S. Donepezil improves obstructive sleep apnea in Alzheimer disease: a double-blind, placebocontrolled study. Chest 2008;133(3):677–683.PubMedCrossRefGoogle Scholar
  95. 95.
    Bliwise DL. Sleep apnea, APOE 4 and Alzheimer’s disease 20 years and counting? J Psychosom Res 2002;53(1):539–546.PubMedCrossRefGoogle Scholar
  96. 96.
    Yesavage JA, Friedman L, Kraemer H, Tinklenberg JR, Salehi A, Noda A, et al. Sleep/wake disruption in Alzheimer’s disease: APOE status and longitudinal course. J Geriatr Psychiatry Neurol 2004;17(1):20–24.PubMedCrossRefGoogle Scholar
  97. 97.
    Brassington GS, King AC, Bliwise DL. Sleep problems as a risk factor for falls in a sample of community-dwelling adults aged 64–99 years. J Am Geriatr Soc 2000;48(10):1234–1240.PubMedGoogle Scholar
  98. 98.
    Cricco M, Simonsick EM, Foley DJ. The impact of insomnia on cognitive functioning in older adults. J Am Geriatr Soc 2001;49(9):1185–1189.PubMedCrossRefGoogle Scholar
  99. 99.
    Manabe K, Matsui T, Yamaya M, Sato-Nakagawa T, Okamura N, Arai H, et al. Sleep patterns and mortality among elderly patients in a geriatric hospital. Gerontology 2000;46(6):318–322.PubMedCrossRefGoogle Scholar
  100. 100.
    Montgomery P. Treatments for sleep problems in elderly people. Bmj 2002;325(7372):1049.PubMedCrossRefGoogle Scholar
  101. 101.
    Gulbay BE, Acican T, Onen ZP, Yildiz OA, Baccioglu A, Arslan F, et al. Healthrelated quality of life in patients with sleep-related breathing disorders: relationship with nocturnal parameters, daytime symptoms and comorbid diseases. Respiration 2008;75(4):393–401.PubMedCrossRefGoogle Scholar
  102. 102.
    Endeshaw Y. Clinical characteristics of obstructive sleep apnea in communitydwelling older adults. J Am Geriatr Soc 2006;54(11):1740–1744.PubMedCrossRefGoogle Scholar
  103. 103.
    Onen SH, Dubray C, Decullier E, Moreau T, Chapuis F, Onen F. Observation-Based Nocturnal Sleep Inventory: Screening Tool for Sleep Apnea in Elderly People. J Am Geriatr Soc 2008. 56:1920–1925.PubMedCrossRefGoogle Scholar
  104. 104.
    Petit D, Lorrain D, Gauthier S, Montplaisir J. Regional spectral analysis of the REM sleep EEG in mild to moderate Alzheimer’s disease. Neurobiol Aging 1993;14(2):141–145.PubMedCrossRefGoogle Scholar
  105. 105.
    Dauvilliers Y. Insomnia in patients with neurodegenerative conditions. Sleep Med 2007;8 Suppl 4:S27–S34.CrossRefGoogle Scholar
  106. 106.
    Phillips B, Ancoli-Israel S. Sleep disorders in the elderly. Sleep Med 2001;2(2):99–114.PubMedCrossRefGoogle Scholar

Copyright information

© Serdi and Springer Verlag France 2009

Authors and Affiliations

  • Valérie Cochen
    • 1
  • C. Arbus
    • 2
  • M. E. Soto
    • 3
  • H. Villars
    • 3
  • M. Tiberge
    • 1
  • T. Montemayor
    • 1
  • C. Hein
    • 3
  • M. F. Veccherini
    • 4
  • S. -H. Onen
    • 5
  • I. Ghorayeb
    • 6
  • M. Verny
    • 7
  • L. J. Fitten
    • 8
  • J. Savage
    • 9
  • Y. Dauvilliers
    • 11
  • B. Vellas
    • 3
  1. 1.Unité du sommeil, service de neurologieHôpital RangueilToulouseFrance
  2. 2.Service de psychiatrieHôpital PurpanToulouseFrance
  3. 3.Gerontopôle/CHU La Grave-CasselarditToulouseFrance
  4. 4.Laboratoire d’explorations fonctionnelleshôpital Bichat-Claude-BernardParisFrance
  5. 5.Unité Gériatrique d’évaluation et de traitement des troubles du sommeilHCLFranchevilleFrance
  6. 6.Service des Explorations Fonctionnelles du Système NerveuxHôpital PellegrinBordeauxFrance
  7. 7.Service de gériatrieHôpital de la SalpétrièreParisFrance
  8. 8.Department of Psychiatry and Biobehavioral SciencesUniversity of California Los Angeles School of MedicineLos AngelesUSA
  9. 9.Department of Psychaiatry and Behavioral SciencesStanford University School of MedicineStanfordUSA
  10. 10.Palo Alto Veterans Affairs Health Care SystemPalo AltoUSA
  11. 11.Service de neurologieHôpital Gui de Chauliac, CHU MontpellierMontpellierFrance
  12. 12.Unité du sommeilCHU RangueilToulouseFrance

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