Probiotics and Antimicrobial Proteins

, Volume 11, Issue 1, pp 124–132 | Cite as

Probiotic Soy Milk Consumption and Renal Function Among Type 2 Diabetic Patients with Nephropathy: a Randomized Controlled Clinical Trial

  • Maryam Miraghajani
  • Nafiseh Zaghian
  • Abolfazl dehkohneh
  • Maryam Mirlohi
  • Reza GhiasvandEmail author


Diabetic nephropathy (DN) is one the most important complications of diabetes leading to end-stage renal disease. Dietary approaches have been considered to control of the kidney function deterioration among these patients. The aim of the present study was to determine the effects of fortified soy milk with Lactobacillus plantarum A7 on renal function biomarkers in type 2 DN patients. Forty-eight DN subjects were attended to this parallel randomized trial study. Participants were randomly assigned to consume a diet containing 200 mL/day probiotic soy milk in intervention group or soy milk in the control condition for 8 weeks. An inflammatory adipokine—Progranulin (PGRN), a cytokine receptor-soluble tumor necrosis factor receptor 1 (sTNFR1), and serum levels of Neutrophil gelatinase-associated lipocalin (NGAL) and cystatin C (Cys-C) as the new renal function biomarkers were measured after 8 weeks of intervention according to the standard protocol. Our analysis showed that consumption of probiotic soy milk resulted in a significant reduction in the Cys-C and PGRN levels compared with the soy milk (P = 0.01) in the final adjusted model. In addition, after adjustment for age, weight, and energy intake, a marginally significant in the NGAL level was seen between two groups (P = 0.05). However, there was no significant differences on the sTNFR1concenteration between two groups (P = 0.06). Overall, intake of probiotic soy milk may have a beneficial effect on the renal function in patients with DN.


Probiotic soy milk L. plantarum A7 Diabetic nephropathy Renal biomarkers 



The authors appreciate the financial support provided by the Research Council of the Food Security Research Center, Isfahan University of Medical Sciences, Isfahan, Iran.

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no conflict of interest.


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Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • Maryam Miraghajani
    • 1
  • Nafiseh Zaghian
    • 2
  • Abolfazl dehkohneh
    • 3
  • Maryam Mirlohi
    • 2
    • 4
  • Reza Ghiasvand
    • 2
    • 5
    Email author
  1. 1.Prevention of Metabolic Disorders Research Center, Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Food Security Research CenterIsfahan University of Medical SciencesIsfahanIran
  3. 3.Department of Biotechnology, Faculty of Advanced Sciences & Technology, Pharmaceutical Sciences BranchIslamic Azad UniversityTehranIran
  4. 4.Department of Food Science and Technology, School of Nutrition and Food ScienceIsfahan University of Medical SciencesIsfahanIran
  5. 5.Department of Community Nutrition, School of Nutrition and Food ScienceIsfahan University of Medical SciencesIsfahanIran

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