The Journal of Physiological Sciences

, Volume 69, Issue 2, pp 327–333 | Cite as

Endurance exercise increases the protein levels of PGC-1α and respiratory chain complexes in mouse skeletal muscle during atorvastatin administration

  • Koji NonakaEmail author
  • Yutaka Ozaki
  • Kenichi Ito
  • Masahiro Sakita
  • Satsuki Une
  • Junichi Akiyama
Original Paper


Statins and exercise reduce cardiovascular disease incidence. We investigated whether endurance exercise in mice induces mitochondrial adaptation in skeletal muscle and muscle injury during administration of atorvastatin, a member of the statin medication class. Male C57BL mice were assigned to one of three groups: control (Con), statin (Statin), or statin and exercise (Statin + Ex). Atorvastatin was administered, and exercise performed on a treadmill for 8 weeks. The levels of mitochondria-associated proteins, PGC-1α, and respiratory chain complex, (COX) I–V, in the quadriceps femoris, and serum creatine kinase, a muscle injury marker, were measured. PGC-1α and COX I–V were upregulated in the Statin + Ex group compared to those in the Statin and Con groups; serum creatine kinase levels were similar. Endurance training in mice induced mitochondrial adaptation in skeletal muscle without causing muscle injury, during atorvastatin administration.


Statin Exercise PGC-1α Respiratory chain complexes Muscle injury 



We would like to thank Editage ( for English language editing.

Author contributions

KN contributed to experimental design, data collection, analysis, and manuscript preparation. YO contributed to experimental design and data collection. KI contributed to experimental design and manuscript preparation. MS, SU, and JA contributed to manuscript preparation.

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All applicable international, national, and/or institutional guidelines for the care and use of animals were followed. All procedures performed in studies involving animals were in accordance with the ethical standards of the institution at which the studies were conducted.


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Copyright information

© The Physiological Society of Japan and Springer Japan KK, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Physical Therapy, Faculty of Health SciencesKyoto Tachibana UniversityKyotoJapan
  2. 2.Department of RehabilitationKansai Electric Power HospitalOsakaJapan
  3. 3.Faculty of Health SciencesNaragakuen UniversityNaraJapan
  4. 4.Faculty of EducationKagawa UniversityTakamatsuJapan
  5. 5.Department of Physical Therapy, School of Health Care and Social WelfareKibi International UniversityTakahashiJapan

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