The suprachiasmatic nucleus: age-related decline in biological rhythms
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Aging is associated with changes in sleep duration and quality, as well as increased rates of pathologic/disordered sleep. While several factors contribute to these changes, emerging research suggests that age-related changes in the mammalian central circadian clock within the suprachiasmatic nucleus (SCN) may be a key factor. Prior work from our group suggests that circadian output from the SCN declines because of aging. Furthermore, we have previously observed age-related infertility in female mice, caused by a mismatch between environmental light–dark cycles and the intrinsic, internal biological clocks. In this review, we address regulatory mechanisms underlying circadian rhythms in mammals and summarize recent literature describing the effects of aging on the circadian system.
KeywordsCircadian rhythm Suprachiasmatic nucleus Aging Estrous cycle Infertility
Multi-unit neural activity
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflicts of interest.
This work was supported by JSPS KAKENHI Grant Numbers 26462809, 26860160, 26861780. N.N.T. is a research fellow of the Japan Society for the Promotion of Science.
- 16.Honma K, Honma S (1988) A human phase response curve for bright light pulses. Jpn J Psychiatr Neurol 42:167–168Google Scholar
- 53.Yoo SH, Yamazaki S, Lowrey PL, Shimomura K, Ko CH, Buhr ED, Siepka SM, Hong HK, Oh WJ, Yoo OJ et al (2004) PERIOD2:LUCIFERASE real-time reporting of circadian dynamics reveals persistent circadian oscillations in mouse peripheral tissues USA. Proc Natl Acad Sci USA 101:5339–5346CrossRefPubMedPubMedCentralGoogle Scholar
- 57.Nakamura TJ, Moriya T, Inoue S, Shimazoe T, Watanabe S, Ebihara S, Shinohara K (2005) Estrogen differentially regulates expression of Per1 and Per2 genes between central and peripheral clocks and between reproductive and nonreproductive tissues in female rats. J Neurosci Res 82:622–630CrossRefPubMedGoogle Scholar