Physiological significance of TRPV2 as a mechanosensor, thermosensor and lipid sensor
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This review provides a summary of the physiological significance of the TRPV2 ion channel. While TRPV2 was initially characterized as a noxious heat sensor, we found that TRPV2 can also act as a mechanosensor in embryonic neurons or adult myenteric neurons. Here, we summarize the newly characterized functions of TRPV2, including the research progress that has been made toward our understanding of TRPV2 physiology, and discuss other recent data pertaining to TRPV2. It is thought that TRPV2 may be an important drug target based on its broad expression patterns and important physiological roles. The possible associations between diseases and TRPV2 are also discussed.
KeywordsTRPV2 Mechanical stimulus Axon outgrowth Mechanosensor Thermosensor
The author would like to acknowledge the following funding sources: Grants-in-Aid for Scientific Research (KAKENHI Project No. 15H05934 <Thermal Biology>, 21200012, 20399554, 24111507 + 26111702 <Brain Environment>, 26117502 <glial assembly>, 15H03000) from the Ministry of Education, Culture, Sports, Science and Technology, Japan; a grant from Uehara Memorial Foundation; a grant from Takeda Science Foundation, Tokyo, Japan; a grant from the Sumitomo Foundation; a grant from the Brain Science Foundation; a grant from Narishige Neuroscience Research Foundation; a grant from Salt Science Research Foundation No.14C2; and a grant from the Ichiro Kanehara Foundation.
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