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The Journal of Physiological Sciences

, Volume 63, Issue 1, pp 55–62 | Cite as

Intravenous infusion of hyperosmotic NaCl solution induces acute cor pulmonale in anesthetized rats

  • Chikara Abe
  • Yoshiharu Tsuru
  • Chihiro Iwata
  • Ryosuke Ogihara
  • Hironobu MoritaEmail author
Original Paper

Abstract

Intravenous hyperosmotic NaCl infusion is an effective treatment for circulatory shock. However, a fast infusion rate (2 mL/kg at the rate of 1 mL/s) induces transient hypotension. This response has been reported to be due to decreased total peripheral resistance and/or decreased cardiac performance. Although the hypotension is transient and recovers within 2 min without detrimental consequences, it is important to understand the associated hemodynamics and mechanisms. We found that the hypotensive effect was larger with intravenous NaCl infusion than with intra-aortic infusion, indicating that change in cardiac performance played a more significant role than change in peripheral resistance. NaCl infusion induced an increase in pulmonary vascular resistance and central venous pressure and a decrease in right ventricular dP/dt max, suggesting acute cor pulmonale. Diastolic ventricular crosstalk-induced left ventricular failure was also observed. Hyperosmotic NaCl-induced hypotension was therefore mainly due to a combination of acute cor pulmonale and left ventricular failure.

Keywords

Arterial pressure Aortic flow Total systemic peripheral resistance Left ventricle Right ventricle dP/dt max 

Notes

Acknowledgments

This study was supported by The Salt Science Research Foundation, No. 1226, a Grant-in-Aid for Young Scientists (B), and a Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science.

Conflict of interest

None.

Supplementary material

Supplementary material 1 (MPG 3410 kb)

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Copyright information

© The Physiological Society of Japan and Springer Japan 2012

Authors and Affiliations

  • Chikara Abe
    • 1
  • Yoshiharu Tsuru
    • 2
  • Chihiro Iwata
    • 1
  • Ryosuke Ogihara
    • 2
  • Hironobu Morita
    • 1
    Email author
  1. 1.Department of PhysiologyGifu University Graduate School of MedicineGifuJapan
  2. 2.Primetech CorporationTokyoJapan

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