Intravenous infusion of hyperosmotic NaCl solution induces acute cor pulmonale in anesthetized rats
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Intravenous hyperosmotic NaCl infusion is an effective treatment for circulatory shock. However, a fast infusion rate (2 mL/kg at the rate of 1 mL/s) induces transient hypotension. This response has been reported to be due to decreased total peripheral resistance and/or decreased cardiac performance. Although the hypotension is transient and recovers within 2 min without detrimental consequences, it is important to understand the associated hemodynamics and mechanisms. We found that the hypotensive effect was larger with intravenous NaCl infusion than with intra-aortic infusion, indicating that change in cardiac performance played a more significant role than change in peripheral resistance. NaCl infusion induced an increase in pulmonary vascular resistance and central venous pressure and a decrease in right ventricular dP/dt max, suggesting acute cor pulmonale. Diastolic ventricular crosstalk-induced left ventricular failure was also observed. Hyperosmotic NaCl-induced hypotension was therefore mainly due to a combination of acute cor pulmonale and left ventricular failure.
KeywordsArterial pressure Aortic flow Total systemic peripheral resistance Left ventricle Right ventricle dP/dt max
This study was supported by The Salt Science Research Foundation, No. 1226, a Grant-in-Aid for Young Scientists (B), and a Grant-in-Aid for Scientific Research (C) from the Japan Society for the Promotion of Science.
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Supplementary material 1 (MPG 3410 kb)
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