The Journal of Physiological Sciences

, Volume 62, Issue 3, pp 173–184 | Cite as

T cells affect thymic involution during puberty by inducing regression of the adrenal reticularis

  • Yoshihiro Kushida
  • Sayaka Kumagai
  • Ken Gotoh
  • Masato Fujii
  • Maki Touma
  • Masamichi Hosono
Original Paper


The thymus involutes after puberty, although the mechanism by which this process occurs remains poorly understood. The profile of thymic involution, which is inversely correlated with an increase in peripheral T cells, may indicate that the accumulation of T cells in the periphery is related to thymic atrophy. In this study, it was shown that the prevention of T cell generation delayed the initiation of thymic involution. The activation of T cells increased the serum concentration of glucocorticoid (GC) and thymic involution, which was completely prevented by adrenalectomy. In the adrenals of growing mice, the activity of the zona fasciculata, which produces GC, increased and plateaued by the weaning period; however, the zona reticularis (ZR), which produces dehydroepiandrosterone (DHEA) that has anti-GC actions, started to decline just before puberty. Thymic atrophy was preceded by the infiltration of activated T cells into the ZR and by the loss of ZR cells. Thus, T cells are involved in thymic involution, a process which was retarded by DHEA administration, through an increase in GC activity due to ZR cell-killing.


Thymic involution T cell-mediated stress GC/DHEA ratio Dynamics of adrenal cortex 



The authors would like to thank Dr. Katsuiku Hirokawa (Emeritus Professor of Tokyo Medical and Dental University), Institute for Health and Life Sciences, Tokyo, Japan, for useful discussions and a critical reading of the manuscript. Thanks are also due to Dr. Shigeyasu Tanaka, Faculty of Science, Shizuoka University, Shizuoka, Japan, for helpful comments and technical advice.


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Copyright information

© The Physiological Society of Japan and Springer 2012

Authors and Affiliations

  • Yoshihiro Kushida
    • 1
  • Sayaka Kumagai
    • 1
  • Ken Gotoh
    • 1
  • Masato Fujii
    • 1
  • Maki Touma
    • 1
  • Masamichi Hosono
    • 1
  1. 1.Laboratory of Immunobiology, Department of Life Science, Graduate School of Science and TechnologyNiigata UniversityNiigataJapan

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