Echocardiographic evaluation of cardiac function after cancer chemotherapy
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Progress in cancer therapy has led to improved prognosis of patients with cancer and thus to a continuous rise of cancer survivors. However, it has simultaneously increased cardiovascular morbidity and mortality rates due to direct and/or indirect side effects of anticancer treatment. Similar to the rapid rise of patients with adult congenital disease, the number of patients suffering or at risk of cardiotoxicity has been steeply increasing and getting an emerging issue. Among the many facets of chemotherapy-induced cardiovascular toxicity, this review attempts to summarize echocardiographic evaluation of cardiac function after cancer chemotherapy by reviewing the definition, risk factors, brief history, limitation of left ventricular ejection fraction and myocardial strain imaging, as well as the limitations of this technique.
KeywordsCancer therapy-related cardiac dysfunction Cardiotoxicity Myocardial strain Ejection fraction Anthracycline Trastuzumab
Compliance with ethical standards
Conflict of interest
Kazuaki Negishi is supported by an award from the Select Foundation, which had no role in the preparation of this manuscript. Kazuaki and Tomoko Negishi declare that they have no conflicts of interest.
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