Journal of Biorheology

, Volume 26, Issue 1–2, pp 11–20 | Cite as

Drift and fluctuating motion of artificial platelets during the lateral transport and adhesion process near the wall

  • Hiroaki Tobimatsu
  • Antoine Paragon
  • Yosuke Okamura
  • Shinji Takeoka
  • Ryo Sudo
  • Yasuo Ikeda
  • Kazuo Tanishita
Original Article
  • 80 Downloads

Abstract

Recombinant glycoprotein Ibα latex beads (rGPIbα-LB) are a potential solution to overcoming platelet transfusion problems with artificial platelets. To understand the transport process of artificial platelets and to estimate the particle motion when adhering to the wall surface, we evaluated the lateral motion of rGPIbα-LB in terms of drift and random motion, because the lateral motion is an important factor for transport and adhesion. We observed the lateral motion of rGPIbα-LB flowing with red blood cells toward the immobilized von Willebrand factor (vWf) surface in a model arteriole at wall shear rates of 200–1000 s−1 and 0–40% Hct. At 40% Hct, wall shear rate dependence was observed for the drift motion, i.e. the lateral velocity of rGPIbα-LB toward the wall. In the near-wall region, the drift motion of contacting particles differed substantially from that of non-contacting particles. Additionally, the trajectories of contacting particles on the vWf surface had specific motion that was not observed on the BSA surface. These results suggest that the adhesion force between rGPIbα and vWf is highly associated with the motion of particles near the wall. These features are desirable for artificial platelets, particularly for the adhesion process.

Keywords

Blood flow Glycoprotein Ibα von Willebrand factor Lateral motion Near-wall excess Adhesion 

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Copyright information

© Japanese Society of Biorheology 2011

Authors and Affiliations

  • Hiroaki Tobimatsu
    • 1
  • Antoine Paragon
    • 1
  • Yosuke Okamura
    • 2
  • Shinji Takeoka
    • 2
  • Ryo Sudo
    • 1
  • Yasuo Ikeda
    • 3
  • Kazuo Tanishita
    • 1
  1. 1.Department of System Design Engineering, School of Science and TechnologyKeio UniversityYokohamaJapan
  2. 2.Department of Life Science and Medical Bioscience, Graduate School of Advanced Science and EngineeringWaseda UniversityTokyoJapan
  3. 3.School of MedicineKeio UniversityTokyoJapan

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