Food Security

, Volume 8, Issue 4, pp 865–870 | Cite as

Genetic modification for disease resistance: a position paper

  • Peter ScottEmail author
  • Jennifer Thomson
  • David Grzywacz
  • Serge Savary
  • Richard Strange
  • Jean B. Ristaino
  • Lise Korsten
Original Paper


This Position Paper was prepared by members of the Task Force on Global Food Security of the International Society for Plant Pathology. An objective approach is proposed to the assessment of the potential of genetic modification (GM) to reduce the impact of crop diseases. The addition of GM to the plant breeder’s conventional toolbox facilitates gene-by-gene introduction into breeding programmes of well-defined characters, while also allowing access to genes from a greatly extended range of organisms. The current status of GM crops is outlined. GM could make an additional contribution to food security but its potential has been controversial, sometimes because of fixed views that GM is unnatural and risky. These have no factual basis: GM technology, where adopted, is widely regulated and no evidence has been reported of adverse consequences for human health. The potential benefits of GM could be particularly valuable for the developing world but there are numerous constraints. These include cost, inadequate seed supply systems, reluctance to adopt unfamiliar technology, concern about markets, inadequacy of local regulatory systems, mismatch between research and growers’ needs, and limited technical resources. The lower cost of new gene-editing methods should open the practice of GM beyond multinational corporations. As yet there are few examples of utilization of GM-based resistance to plant diseases. Two cases, papaya ringspot virus and banana xanthomonas wilt, are outlined. In the developing world there are many more potential cases whose progress is prevented by the absence of adequate biosafety regulation. It is concluded that there is untapped potential for using GM to introduce disease resistance. An objective approach to mobilizing this potential is recommended, to address the severe impact of plant disease on food security.


Genetic modification Genetic engineering Plant breeding Food security Disease resistance Developing countries Biosafety 


  1. Adenle, A. A., Moris, E. J., & Parayil, G. (2013). Status of development, regulation and adoption of GM agriculture in Africa: views and positions of stakeholder groups. Food Policy, 43, 159–166.CrossRefGoogle Scholar
  2. Bailey, R., Willoughby, R., & Grzywacz, D. (2014). On trial: agricultural biotechnology in Africa. Chatham House Research Paper: Energy, Environment and Resources July 2014, 1–26.Google Scholar
  3. Bennett, D. J., & Jennings, R. C. (2014). Successful Agricultural Innovation in Emerging Economies: New Genetic Technologies for Global Food Production. UK: Cambridge University Press.Google Scholar
  4. Collinge, D. B. (Ed.) (2016). Plant pathogen resistance biotechnology. Hoboken: Wiley-Blackwell.Google Scholar
  5. Collinge, D. B., Mullins, E., Jensen, B., & Jørgensen, H. J. L. (2016). The status and prospects for biotechnological approaches for attaining sustainable disease resistance. Plant Pathogen Resistance Biotechnology, 1–20. Hoboken: Wiley-Blackwell.CrossRefGoogle Scholar
  6. Delmer, D., Nottenburg, C., Graff, D., & Bennett, A. (2003). Intellectual property resources for international development in agriculture. Plant Physiology, 133, 1666–1670.CrossRefPubMedPubMedCentralGoogle Scholar
  7. European Commission (2015). Restrictions of geographical scope of GMO applications/authorisations: Member States demands and outcomes.
  8. Evenson, R. E., & Gollin, D. (2003). Assessing the impact of the green revolution, 1960 to 2000. Science, 300, 758–762.CrossRefPubMedGoogle Scholar
  9. FAO (2015). The Millennium Development Goals Report 2015.
  10. Fermin, G. M., Castro, L. T., & Tennant, P. F. (2010). CP-transgenic and non-transgenic approaches for the control of papaya ringspot: current situation and challenges. Transgenic Plant Journal, 4, 1–15.Google Scholar
  11. James, C. (2015). Global Status of Commercialized Biotech/GM Crops: 2015. ISAAA Brief no. 51. International Service for the Acquisition of Agri-biotech applications, Ithaca, New York.Google Scholar
  12. Ledford, H. (2015). CRISPR, the disruptor. Nature, 522, 20–24.CrossRefPubMedGoogle Scholar
  13. National Academies of Sciences, Engineering, and Medicine (2016). Genetically Engineered Crops: Experiences and Prospects. Washington, DC: The National Academies Press 388 pp.Google Scholar
  14. Oerke, E. C., & Dehne, H. W. (2008). Safeguarding production losses in major crops and the role of crop protection. Crop Protection, 23, 275–285.CrossRefGoogle Scholar
  15. Qaim, M. (2015). Genetically modified crops and agricultural development. Palgrave Studies in Agricultural Economics and Food Policy. London: Palgrave Macmillan.Google Scholar
  16. Sanvido, O., Romeis, J., & Bigler, F. (2007). Ecological impacts of genetically modified crops: ten years of field research and commercial cultivation. Green Gene Technology, Advances in Biochemical Engineering/Biotechnology, 107, 235–278.CrossRefGoogle Scholar
  17. Suzie, K., Julian, K.-C. M., & Pascal, M. W. D. (2008). Genetically modified plants and human health. Journal of the Royal Society of Medicine, 101, 290–298.CrossRefGoogle Scholar
  18. Tester, M., & Langridge, P. (2010). Breeding technologies to increase crop production in a changing world. Science, 327, 818–822.CrossRefPubMedGoogle Scholar
  19. Tripathi, S., Suzuki, J., Ferreira, S., & Gonsalves, D. (2008). Papaya ringspot virus-P: characteristics, pathogenicity, sequence variability and control. Molecular Plant Pathology, 9, 269–280.CrossRefPubMedGoogle Scholar
  20. Tripathi, L., Mwangi, M., Aritua, V., Tushemereirwe, W. K., Steffen, A., & Ranajit, B. (2009). Xanthomonas wilt: a threat to banana production in east and Central Africa. Plant Disease, 93, 440–451.CrossRefGoogle Scholar
  21. US Census Bureau (2015). US Census Bureau International Database.
  22. World Health Organization (2014). Frequently asked questions on genetically modified foods.

Copyright information

© Springer Science+Business Media Dordrecht and International Society for Plant Pathology 2016

Authors and Affiliations

  1. 1.International Society for Plant PathologyOxfordUK
  2. 2.Department of Molecular and Cell BiologyUniversity of Cape TownRondeboschRepublic of South Africa
  3. 3.NRI - Department of Agriculture Health and EnvironmentUniversity of Greenwich, Old Royal Naval CollegeLondonUK
  4. 4.INRA, UMR1248 AGIRUniversité ToulouseToulouseFrance
  5. 5.Department of Genetics, Evolution and EnvironmentUniversity College LondonLondonUK
  6. 6.USAID Senior Science Advisor, Department of Plant PathologyNorth Carolina State UniversityRaleighUSA
  7. 7.Department of Microbiology and Plant PathologyUniversity of PretoriaPretoriaRepublic of South Africa

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