Computer-Aided Diagnosis of Ataxia SCA-2 Using a Blind Source Separation Algorithm
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This work discusses a new approach for ataxia SCA-2 diagnosis based on the application of independent component analysis to the data obtained by electro-oculography in several experiments carried out over healthy and sick subjects. Abnormalities in the oculomotor system are well-known clinical symptoms in patients of several neurodegenerative diseases, including modifications in latency, peak velocity, and deviation in saccadic movements, causing changes in the waveform of the patient response. The changes in the morphology waveform suggest a higher degree of statistic independence in sick patients when compared to healthy individuals regarding the patient response to the visual saccadic stimulus modeled by means of digital generated saccade waveforms. The electro-oculogram records of thirteen patients diagnosed with ataxia SCA2 (a neurodegenerative hereditary disease) and thirteen healthy subjects used as control were processed to extract saccades.
KeywordsIndependent component analysis Blind source separation Biomedical engineering Computer-aided diagnosis
The authors would like to thank the rest of the personnel in the Centre for the Research and Rehabilitation of Hereditary Ataxias “Carlos J. Finlay”, Holguín, (Cuba) for their support and collaboration. This work has been partially supported by the Spanish MAEC-AECID fellowship program (2008 and 2009). Special thanks to the reviewers for their helpful comments that improved this contribution.
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