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Optimal planning strategies for high-grade gliomas : a dosimetric study on ten patients

Optimisation de la planification des stratégies pour les gliomes de haut grade. Étude dosimétrique sur dix patients

  • Original Article / Article Original
  • Published:
Journal Africain du Cancer / African Journal of Cancer

Abstract

Purpose

To identify the optimal technique of radiotherapy for patients with high-grade glioma.

Materials and methods

CT scans of 10 patients with grade IV glioma were reviewed for the treatment planning. Three different treatment plans were generated using 3D conformal radiotherapy (3DCRT), intensity-modulated radiotherapy (IMRT), and RapidArc (RA), and the plans were compared.

Results

Planning target volume (PTV) coverage was comparable. However, IMRT and RA gave better sparing of critical structures. Treatment time and monitor units (MU) for RapidArc were much less when compared to IMRT. Conclusions: If PTV is near to the organs at risk (OAR), then IMRT gives good results in comparison to 3DCRT plans. RapidArc is faster than IMRT and 3DCRT for same dose prescription to PTV and constraints of OAR.

Résumé

Objectif

Identifier la technique optimale de radiothérapie pour les patients porteurs de gliome de haut grade.

Matériel et méthodes

Les tomodensitogrammes prévisionnels de dix patients porteurs de gliomes de grade IVont été analysés. Trois séries de plans ont été générés et comparés: radiothérapie conformationelle 3D (3DCRT), radiothérapie avec modulation d’intensité (IMRT) et arcthérapie dynamique (RA).

Résultats

La couverture du volume cible prévisionnel (PTV) est comparable. Cependant l’IMRT et le RA préservent davantage les organes critiques. Le temps de traitement et le nombre d’unités moniteur (MU) en arcthérapie sont nettement inférieurs à ceux de l’IMRT.

Conclusions

Si le PTV est proche d’organes à risque (OAR), l’IMRT donne des résultats satisfaisants par rapport aux plans 3DCRT. L’arcthérapie est plus rapide que l’IMRT et le 3DCRT pour les mêmes prescriptions de dose pour le PTV et les mêmes contraintes d’OAR.

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Authors and Affiliations

  1. Department of Radiation Oncology, Apollo Gleneagles Cancer Hospital, Calcutta, India

    B. Goswami, S. Banerjee, S. Mitra, A. B. Shiva, P. Nagendran, S. S. Biswal, M. Gazi, A. Chakraborty & S. Mukherjee

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  1. B. Goswami
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  2. S. Banerjee
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  3. S. Mitra
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  4. A. B. Shiva
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  5. P. Nagendran
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  6. S. S. Biswal
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  7. M. Gazi
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  8. A. Chakraborty
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  9. S. Mukherjee
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Corresponding author

Correspondence to B. Goswami.

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Goswami, B., Banerjee, S., Mitra, S. et al. Optimal planning strategies for high-grade gliomas : a dosimetric study on ten patients. J Afr Cancer 4, 168–170 (2012). https://doi.org/10.1007/s12558-012-0219-8

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  • DOI: https://doi.org/10.1007/s12558-012-0219-8

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