Compression médullaire en oncologie

  • Z. Fadoukhair
  • I. Lalya
  • M. Amzerin
  • N. Ismaili
  • R. Belbaraka
  • Y. Bensouda
  • S. Elmajjaoui
  • S. Boutayeb
  • N. Benjaafar
  • B. K. El Gueddari
  • H. M’rabti
  • H. Errihani
Article Original / Original Article
  • 106 Downloads

Résumé

La compression médullaire d’origine métastatique est une complication assez fréquente en oncologie. C’est une urgence diagnostique et thérapeutique. Le pronostic fonctionnel, la survie et la qualité de vie du patient dépendent essentiellement de la précocité du diagnostic et de la rapidité de la prise en charge. Il ne faut surtout pas attendre l’apparition des troubles neurologiques pour démarrer le traitement. L’IRM médullaire reste l’examen clé dans le diagnostic de la compression médullaire. La prise en charge thérapeutique doit être impérativement pluridisciplinaire et inclut la corticothérapie, la radiothérapie (RTH) et la chirurgie en fonction des indications.

Mots clés

Compression médullaire métastatique IRM Corticostéroïdes Radiothérapie Neurochirurgie Urgence 

Malignant spinal cord compression

Abstract

Malignant spinal-cord compression (MSCC) is a common complication in oncology. It is an emergency diagnosis and therapeutic. The functional outcome, survival, and quality of life of the patient depend mainly on early diagnosis and rapid management. It is important to start treatment before the onset of neurological disorders. Spinal cord MRI remains the key examination in the diagnosis of spinal cord compression. The therapeutic management should be multidisciplinary and includes steroids, radiation and surgery according to indications.

Keywords

Metastatic spinal cord compression MRI Corticosteroids Radiotherapy Neurosurgery Emergency 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

Références

  1. 1.
    Loblaw DA, Laperriere NJ (1998) Emergency treatment of malignant extradural spinal cord compression: An evidence-based guideline. J Clin Oncol 16:1613PubMedGoogle Scholar
  2. 2.
    Spiller WG (1925) Rapidly progressive paralysis associated with carcinoma. Arch Neurol Psychiatry 13:471Google Scholar
  3. 3.
    Loblaw DA, Laperriere NJ, Mackillop WJ (2003) A populationbased study of malignant spinal cord compression in Ontario cancer patients. Clin Oncol 15:211–217CrossRefGoogle Scholar
  4. 4.
    Schiff D, O’Neill BP, Suman VJ (1997) Spinal epidural metastasis as the initial manifestation of malignancy: Clinical features and diagnostic approach. Neurology 49:452PubMedCrossRefGoogle Scholar
  5. 5.
    Levack P, Graham J, Collie D, et al (2002) Don’t wait for a sensory level-listen to the symptoms: a prospective audit of the delays in diagnosis of malignant cord compression. Clin Oncol 14:472–480CrossRefGoogle Scholar
  6. 6.
    Turner S, Marosszeky B, Timms I, Boyages J (1993) Malignant spinal cord compression: a prospective evaluation. Int J Radiat Oncol Biol Phys 26:141–146PubMedCrossRefGoogle Scholar
  7. 7.
    Flounders JA, Ott BB (2003) Oncology emergency modules: spinal cord compression. Oncol Nurs Forum 30:E17–E23PubMedCrossRefGoogle Scholar
  8. 8.
    Misserand G, Court C (2007) Le rôle de l’urgentiste dans la prise en charge des métastases rachidiennes. J Eur Urg 20:28–31Google Scholar
  9. 9.
    Feiz-Erfan I, Rhines LD, Weinberg JS (2008) The role of surgery in the management of metastatic spinal tumors. Semin Oncol 35:108–117PubMedCrossRefGoogle Scholar
  10. 10.
    Traul DE, Shaffrey ME, Schiff D (2007) Spinal-cord neoplasmsintradural neoplasms. Lancet Oncol 8:35–45PubMedCrossRefGoogle Scholar
  11. 11.
    Helweg-Larsen S, Sorensen PS (1994) Symptoms and signs in metastatic spinal cord compression: a study of progression from first symptom until diagnosis in 153 patients. Eur J Cancer 30:396–398CrossRefGoogle Scholar
  12. 12.
    Gilbert RW, Kim JH, Posner JB (1978) Epidural spinal cord compression from metastatic tumor: diagnosis and treatment. Ann Neurol 3:40PubMedCrossRefGoogle Scholar
  13. 13.
    Frankel HL, Hancock DO, Hyslop G, et al (1969) The value of postural reduction in the initial management of closed injuries of the spine with paraplegia and tetraplegia. Paraplegia 7:179–192PubMedCrossRefGoogle Scholar
  14. 14.
    Husband DJ (1998) Malignant spinal cord compression: prospective study of delays in referral and treatment. BJM 317:18–21CrossRefGoogle Scholar
  15. 15.
    Guillevin R, Vallee JN, Lafitte F, et al (2007) Spine metastasis imaging: review of the literature. J Neuroradiol 34:311–321PubMedCrossRefGoogle Scholar
  16. 16.
    Solberg A, Bremnes RM (1999) Metastatic spinal cord compression: diagnostic delay, treatment, and outcome. Anticancer Res 19:677PubMedGoogle Scholar
  17. 17.
    Tokuhashi Y, Matsuaki H, Oda H, et al (2005) A revised scoring system for preoperative evaluation of metastatic spine tumor prognosis. Spine 30:2186–2191PubMedCrossRefGoogle Scholar
  18. 18.
    Constans JP, de Divitiis E, Donzelli R, et al (1983) Spinal metastases with neurological manifestations. Review of 600 cases. J Neurosurg 59:111PubMedCrossRefGoogle Scholar
  19. 19.
    Dworkin RH, O’Connor AB, Backonja M, et al (2007) Pharmacologic management of neuropathic pain: evidence-based recommendations. Pain 132:237–251PubMedCrossRefGoogle Scholar
  20. 20.
    Koehler PJ (1995) Use of corticosteroids in neuro-oncology. Anticancer Drugs 6:19–33PubMedCrossRefGoogle Scholar
  21. 21.
    Hayashi T, Sakurai M, Abe K, et al (1999) Expression of angiogenic factors in rabbit spinal cord after transient ischemia. Neuropathol Appl Neurobiol 25:63–71PubMedCrossRefGoogle Scholar
  22. 22.
    Helweg-Larsen S, Sorensen PS, Kreiner S (2000) Prognostic factors in metastatic spinal cord compression: a prospective study using multivariate analysis of variables influencing survival and gait function in 153 patients. Int J Radiat Oncol Biol Phys 46:1163PubMedCrossRefGoogle Scholar
  23. 23.
    Bach F, Larsen BH, Rohde K, et al (1990) Metastatic spinal cord compression. Occurrence, symptoms, clinical presentations and prognosis in 398 patients with spinal cord compression. Acta Neurochir (Wien) 107:37CrossRefGoogle Scholar
  24. 24.
    Loblaw DA, Perry J, Chambers A, Laperriere NJ (2005) Systematic review of the diagnosis and management of malignant extradural spinal cord compression. J Clin Oncol 23:2028–2037PubMedCrossRefGoogle Scholar
  25. 25.
    Vecht CJ, Haaxma-Reiche H, Van Putten W, et al (1989) Initial bolus of conventional versus high-dose dexamethasone in metastatic spinal cord compression. Neurology 39:1255–1257PubMedCrossRefGoogle Scholar
  26. 26.
    Maranzano E, Latini P, Beneventi S, et al (1996) Radiotherapy without steroids in selected metastatic spinal cord compression patients: a Phase II trial. Am J Clin Oncol 19:179–183PubMedCrossRefGoogle Scholar
  27. 27.
    Kovner F, Spigel S, Rider I, et al (1999) Radiation therapy of metastatic spinal cord compression. Multidisciplinary team diagnosis and treatment. J Neuro-oncol 42:85–92CrossRefGoogle Scholar
  28. 28.
    Maranzano E, Latini P, Checcaglini F, et al (1991) Radiation therapy in metastatic spinal cord compression. Cancer 67:1311–1317PubMedCrossRefGoogle Scholar
  29. 29.
    Maranzano E, Latini P, Perrucci E, et al (1997) Short-course radiotherapy in metastatic spinal cord compression: an effective and feasible treatment. Int J Radiat Oncol Biol Phys 38:1037–1044PubMedCrossRefGoogle Scholar
  30. 30.
    Rock JP, Ryu S, Yin FF, et al (2004) The evolving role of stereotactic radiosurgery and stereotactic radiation therapy for patients with spine tumors. J Neuro-oncol 69:319–334CrossRefGoogle Scholar
  31. 31.
    Sundaresan N, Sachdev VP, Holland JF, et al (1995) Surgical treatment of spinal cord compression from epidural metastasis. J Clin Oncol 13:2330–2335PubMedGoogle Scholar
  32. 32.
    Young RF, Post EM, King GA (1980) Treatment of spinal epidural metastases. Randomized prospective comparison of laminectomy and radiotherapy. J Neurosurg 53:741–748PubMedCrossRefGoogle Scholar
  33. 33.
    Klimo P, Thompson C, Kestle J (2005) A meta-analysis of surgery versus conventional radiotherapy for the treatment of metastatic spinal epidural disease. Neuro Oncol 7:64–76PubMedCrossRefGoogle Scholar
  34. 34.
    Patchell RA, Tibbs PA, Regine WF (2005) Direct decompressive surgical resection in the treatment of spinal cord compression caused by metastatic cancer: a randomized trial. Lancet 366:643–648PubMedCrossRefGoogle Scholar
  35. 35.
    Wong ET, Portlock CS, O’Brien JP, De Angelis LM (1996) Chemosensitive epidural spinal cord disease in non-Hodgkins lymphoma. Neurology 46:1543–1547PubMedCrossRefGoogle Scholar
  36. 36.
    Burch PA, Grossman SA (1988) Treatment of epidural cord compressions from Hodgkins disease with chemotherapy. Am J Med 84:555–558PubMedCrossRefGoogle Scholar
  37. 37.
    Cooper K, Bajorin D, Shapiro W, et al (1990) Decompression of epidural metastases from germ cell tumorswith chemotherapy. J Neurooncol 8:275–280PubMedCrossRefGoogle Scholar
  38. 38.
    Ruff RL, Ruff SS, Wang X (2007) Persistent benefits of rehabilitation on pain and life quality for non ambulatory patients with spinal epidural metastasis. J Rehabil Res Dev 44:271–278PubMedCrossRefGoogle Scholar

Copyright information

© Springer Verlag France 2012

Authors and Affiliations

  • Z. Fadoukhair
    • 1
  • I. Lalya
    • 2
  • M. Amzerin
    • 1
  • N. Ismaili
    • 1
  • R. Belbaraka
    • 1
  • Y. Bensouda
    • 1
  • S. Elmajjaoui
    • 2
  • S. Boutayeb
    • 1
  • N. Benjaafar
    • 2
  • B. K. El Gueddari
    • 2
  • H. M’rabti
    • 1
  • H. Errihani
    • 1
  1. 1.Service d’oncologie médicaleInstitut national d’oncologieRabatMaroc
  2. 2.Service de radiothérapieInstitut national d’oncologieRabatMaroc

Personalised recommendations