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Health and Technology

, Volume 7, Issue 1, pp 61–70 | Cite as

Lung mechanics - airway resistance in the dynamic elastance model

  • B. LauferEmail author
  • J. Kretschmer
  • P. D. Docherty
  • Y. S. Chiew
  • K. Möller
Original Paper
  • 140 Downloads
Part of the following topical collections:
  1. Systems Medicine

Abstract

The selection of optimal positive end-expiratory pressure (PEEP) levels during mechanical ventilation therapy of patients with acute respiratory distress syndrome (ARDS) remains a problem for clinicians. A particular mooted strategy states that minimizing the energy transferred to the lung during mechanical ventilation could potentially be used to determine the optimal, patient-specific PEEP levels. Furthermore, the dynamic elastance model of pulmonary mechanics could possibly be applied to minimize the energy by localization of the patients’ minimum dynamic elastance range. The sensitivity of the dynamic elastance model to variance in the airway resistance was analyzed. Additionally, the airway resistance was determined by using three other established identification methods and was compared to the constant resistance obtained by the dynamic elastance model. For increasing PEEP, the alternative identification methods showed similar decreasing trends of the resistance during inspiration. This declining trend is apparently an exponential decrease. Results showed that the constant airway resistance, presumed by the dynamic elastance model, has to be rechecked and investigated.

Keywords

Lung mechanics Physiological modelling First order model Dynamic elastance model Mechanical ventilation Airway resistance 

Notes

Acknowledgments

This work was partially supported by the EU (eTime, Grant FP7-PIRSES 318943).

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

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Copyright information

© IUPESM and Springer-Verlag Berlin Heidelberg 2016

Authors and Affiliations

  1. 1.Institute of Technical Medicine (ITeM)Furtwangen UniversityVillingen-SchwenningenGermany
  2. 2.Department of Mechanical EngineeringUniversity of CanterburyChristchurchNew Zealand
  3. 3.School of EngineeringMonash University MalaysiaBandar SunwayMalaysia

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