Central blood pressure monitoring method oriented to wearable devices
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Abstract
Arterial hypertension affects a quarter of the world’s population and is a major risk factor for cardiovascular disease. Blood pressure (BP) is one of the most relevant parameters used for continual monitoring of possible hypertension states in the elderly population. Furthermore, emerging evidence suggests that central blood pressure is a more accurate predictor of future cardiovascular events than brachial pressure, thus potentially providing a better hemodynamic determinant for clinical outcomes. This work presents a non-invasive Central (Aortic) blood pressure estimation method based on the pulse transit time (ptt) principle estimated from electrocardiogram (ECG) and ballistocardiogram (BCG) recordings. As the measured transit time presented takes place mainly within the aortic domain, we estimate aortic blood pressure instead of brachial pressure. Validation of the proposed method was performed with a small sample of healthy volunteers at a local gym. An Atcor Medical SphygmoCor device was used to monitor central and brachial blood pressure (systolic, mean, and diastolic) during rests of the strength maneuvers. Pulse transit time was estimated from ECG and BCG recordings and simultaneously recorded with all BP readings. Results showed that Systolic and Mean central blood pressures were most strongly correlated with ppt-estimated blood pressure in comparison to all other blood pressure readings; Bland-Altman plots showed an almost zero mean error (|μ|< 0.02mmHg) and bounded standard deviation σ< 5mmHg for all systolic and mean central BP readings. Experimental data, thus showed promissory results for monitoring aortic blood pressure via ptt. The scope of this pilot work is to provide initial validation of this method in order to develop a compact miniaturized device that allows the integration of wireless blood pressure monitoring into a wearable system.
Keywords
Blood pressure monitoring Central blood pressure Pulse transit time (ptt) Electrocardiogram (ECG) Ballistocardiogram (BCG) Wearable systemNotes
Compliance with Ethical Standards
All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.
Conflict of interests
Author G. Fierro has received research grants from Comisión Académica de Posgrado - Universidad de la República. Author F. Silveira declares that he has no conflict of interest. Author R. Armentano declares that he has no conflict of interest.
Informed consent
Informed consent was obtained from all individual participants included in the study.
Funding
This study was funded by Comisión Académica de Posgrado - Universidad de la República and Comisión Coordinadora del Interior - Universidad de la República.
References
- 1.Armentano R, Kun L. Multidisciplinary, holistic and patient specific approach to follow up elderly adults. Heal Technol 2014;4(2):95–100.CrossRefGoogle Scholar
- 2.Bellomo G, Narducci PL, Rondoni F, Pastorelli G, Stangoni G, Angeli G, Verdecchia P. Prognostic value of 24-hour blood pressure in pregnancy. Obstet Gynecol Surv 2000;55(4):196–198.CrossRefGoogle Scholar
- 3.Corradetti A. Ambulatory blood pressure monitoring in pregnancy. 2011.Google Scholar
- 4.Da He D, Winokur ES, Sodini CG. An ear-worn vital signs monitor. IEEE Trans Biomed Eng 2015;62(11):2547–2552.CrossRefGoogle Scholar
- 5.Espina J, Falck T, Muehlsteff J, Jin Y, Adán MA, Aubert X. Wearable body sensor network towards continuous cuff-less blood pressure monitoring. Medical Devices and Biosensors, 2008. ISSS-MDBS 2008. 5th International Summer School and Symposium on IEEE; 2008. p. 28–32.Google Scholar
- 6.Geddes LA. Handbook of blood pressure measurement Springer Science & Business Media. 1991.Google Scholar
- 7.Gholamhosseini H, Biswas J, Zhang H, Jayachandran M, Baig MM. Cuff-less, non-invasive and continuous blood pressure monitoring using indirect methods. Industrial Electronics and Applications (ICIEA), Conference on 2015 IEEE 10th; 2015. p. 233–237. doi: 10.1109/ICIEA.2015.7334117.
- 8.He DD, Winokur ES, Heldt T, Sodini CG. The ear as a location for wearable vital signs monitoring. 2010 Annual International Conference of the IEEE Engineering in Medicine and Biology; 2010. p. 6389–6392. doi: 10.1109/IEMBS.2010.5627309.
- 9.Khan KS, Wojdyla D, Say L, Gülmezoglu AM, Van Look PF. Who analysis of causes of maternal death: a systematic review. The lancet 2006;367(9516):1066–1074.CrossRefGoogle Scholar
- 10.Lin H, Xu W, Guan N, Ji D, Wei Y, Yi W. Noninvasive and continuous blood pressure monitoring using wearable body sensor networks. IEEE Intell Syst 2015;30(6):38–48. doi: 10.1109/MIS.2015.72.CrossRefGoogle Scholar
- 11.Noh S, Yoon C, Hyun E, Yoon HN, Chung T, Park K, Kim H. Ferroelectret film-based patch-type sensor for continuous blood pressure monitoring. Electron Lett 2014;50(3):143–144.CrossRefGoogle Scholar
- 12.Peter L, Noury N, Cerny M. A review of methods for non-invasive and continuous blood pressure monitoring: Pulse transit time method is promising?. IRBM 2014;35(5):271–282.CrossRefGoogle Scholar
- 13.Pinheiro E, Postolache O, Girão P. Theory and developments in an unobtrusive cardiovascular system representation: ballistocardiography. Open Biomed Eng J 2010;4:201.CrossRefGoogle Scholar
- 14.Puke S, Suzuki T, Nakayama K, Tanaka H, Minami S. Blood pressure estimation from pulse wave velocity measured on the chest. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC);2013. p. 6107–6110. doi: 10.1109/EMBC.2013.6610946.
- 15.Roberts JM, Pearson G, Cutler J, Lindheimer M. Summary of the nhlbi working group on research on hypertension during pregnancy. 2003.Google Scholar
- 16.Sola J, Proenca M, Chetelat O. Wearable pwv technologies to measure blood pressure: eliminating brachial cuffs. Engineering in Medicine and Biology Society (EMBC), 2013 35th Annual International Conference of the IEEE, pp. 4098–4101. IEEE; 2013.Google Scholar
- 17.Thom SM, Cruickshank K, Stanton A, Collier D, Hughes AD, Thurston H. Differential impact of blood pressure–lowering drugs on central aortic pressure and clinical outcomes. Circulation 2006;113:1213–1225.CrossRefGoogle Scholar
- 18.Waugh J, Bosio P, Habiba M, Boyce T, Shennan A, Halligan A. Home monitoring of blood pressure in pregnancy at high risk of pre-eclampsia. Eur J Obstet Gynecol Reprod Biol 2001;99(1):109–111.CrossRefGoogle Scholar
- 19.Westerhof N, Stergiopulos N, Noble MI. Snapshots of hemodynamics: an aid for clinical research and graduate education Springer Science & Business Media. 2010.Google Scholar
- 20.William RS, Samuel AT, John RB, Maurice BR, William D, William RS, Hamilton WF, John ES, John LN, Samuel AT, Isaac S. Proposals for ballistocardiographic nomenclature and conventions: revised and extended report of committee on ballistocardiographic terminology. Circulation 1956;14(3):435–450.CrossRefGoogle Scholar
- 21.Winokur ES, He DD, Sodini CG. A wearable vital signs monitor at the ear for continuous heart rate and pulse transit time measurements. 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society; 2012. p. 2724–2727. doi: 10.1109/EMBC.2012.6346527.
- 22.Zheng Y, Yan BP, Zhang Y, Yu CM, Poon CCY. Wearable cuff-less ptt-based system for overnight blood pressure monitoring. 2013 35th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC); 2013. p. 6103–6106. doi: 10.1109/EMBC.2013.6610945.