In this short review, I describe a brief history of the discovery of myosin I isolated from Acanthamoeba in 1973 by Tom Pollard and Ed Korn. Today, myosins form a large “family tree” that includes more than 30 types of myosins. I discuss the importance of the relationship among actin, myosin, and other actin-binding proteins, many of which were pioneered by Pollard-san (“-san” is a Japanese honorific suffix showing respect, politeness and friendship). At the first conference devoted to actin, Pollard-san, Korn-san, and I discussed the importance of the nucleotide bound at the two ends of the actin filament. I conclude that life is a dynamic accumulation of molecule-molecule bindings, and although we do not yet know how they coordinate with each other to operate a living cell, many enthusiastic and excellent researchers like Pollard-san will unveil mechanisms that will show us what life really looks like.
Actin Myosin Acanthamoeba
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I thank the editors Cris dos Remedios and Enrique De La Cruz, who helped editing this short review. I am also grateful to Shin’ichi Ishiwata and Keiichi Namba for careful reading the manuscript. This short review is a translated transcription of my talk with Ikuko Fujiwara about Pollard-san.
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Conflicts of interest
Fumio Oosawa declares that he has no conflict of interest.
This article does not contain any studies with human participants or animals performed by the author.
Adelman MR, Taylor EW (1969) Further purification and characterization of slime mold myosin and slime mold actin. Biochemistry 8:4976–4988CrossRefGoogle Scholar
Miki M, Barden JA, dos Remedios CG (1987) Spatial relationship between the nucleotide-binding site, Lys-61 and Cys-374 in actin and a conformational change induced by myosin subfragment-1. Eur J Biochem 168:339–345CrossRefGoogle Scholar