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Biophysical Reviews

, Volume 10, Issue 4, pp 1205–1213 | Cite as

Long non-coding RNA expression in bladder cancer

  • Mohammad Taheri
  • Mir Davood Omrani
  • Soudeh Ghafouri-Fard
Review

Abstract

The advent of novel high-throughput sequencing methods has facilitated identification of non-coding RNAs with fundamental roles in cellular biological and pathological conditions. A group of these consisting of at least 200 nucleotides are called long non-coding RNAs (lncRNAs). Their participation in the pathogenesis of cancer has been highlighted in recent years. Bladder cancer, one of the most prevalent cancers worldwide, exhibits altered expression levels of several lncRNAs. Several in vitro and in vivo studies have assessed the effects of silencing RNAs on cancer cell phenotypes and in vivo tumor growth. For instance, in vitro studies have shown that nuclear paraspeckle assembly transcript 1 (NEAT1), promoter of CDKN1A antisense DNA damage-activated RNA(PANDAR) and metastasis-associated lung adenocarcinoma transcript 1(MALAT1) have oncogenic effects while Maternally expressed 3 (MEG3) and BRAF activated non-coding RNA (BANCR) are tumor suppressors. Analysis of these data will help to identify a panel of lncRNAs that can be potentially used for both early detection and prognosis in bladder cancer patients. Here, we review the roles of several lncRNAs in the oncogenesis, tumor suppression, early detection, and prognosis of bladder cancer.

Keywords

lncRNA Bladder cancer Oncogenesis Tumor suppression Cancer prognosis 

Notes

Compliance with ethical standards

Conflict of interest

Mohammad Taheri declares that he has no conflicts of interest. Mir Davood Omrani declares that he has no conflicts of interest. Soudeh Ghafouri-Fard declares that she has no conflicts of interest.

Ethical approval

This article does not contain any studies with human participants or animals performed by any of the authors.

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Copyright information

© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Mohammad Taheri
    • 1
    • 2
  • Mir Davood Omrani
    • 1
    • 2
  • Soudeh Ghafouri-Fard
    • 2
  1. 1.Urogenital Stem Cell Research CenterShahid Beheshti University of Medical SciencesTehranIran
  2. 2.Department of Medical GeneticsShahid Beheshti University of Medical SciencesTehranIran

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