Assembly and remodeling of viral DNA and RNA replicons regulated by cellular molecular chaperones
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A variety of cellular reactions mediated by interactions among proteins and nucleic acids requires a series of proteins called molecular chaperones. The viral genome encodes relatively few kinds of viral proteins and, therefore, host-derived cellular factors are required for virus proliferation. Here we discuss those cellular proteins known as molecular chaperones, which are essential for the assembly of functional viral DNA/RNA replicons. The function of these molecular chaperones in the cellular context is also discussed.
KeywordsAdenovirus Chromatin Influenza virus Molecular chaperone Ribonucleoprotein
We gratefully acknowledge all the collaborators who have contributed to our research projects. In particular, we thank Drs. Fumitaka Momose (Kitasato University) and Tadasuke Naito (Kawasaki Medical School) for their efforts.
The research work was supported in part by grants-in-aid from the Ministry of Education, Culture, Sports, Science and Technology of Japan (16H05192 for AK and 24115002 for KN).
Compliance with ethical standards
Conflict of interest
Takeshi Sekiya declares that he has no conflicts of interest. Yifan Hu declares that he has no conflicts of interest. Kohsuke Kato declares that he has no conflicts of interest. Mitsuru Okuwaki declares that he has no conflicts of interest. Atsushi Kawaguchi declares that he has no conflicts of interest. Kyosuke Nagata declares that he has no conflicts of interest.
This article does not contain any studies with human participants or animals performed by any of the authors.
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