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Biophysical Reviews

, Volume 6, Issue 1, pp 3–14 | Cite as

Classical protein kinases C are regulated by concerted interaction with lipids: the importance of phosphatidylinositol-4,5-bisphosphate

  • Senena Corbalán-GarcíaEmail author
  • Juan C. Gómez-FernándezEmail author
Review

Abstract

Classical protein kinase C (PKC) enzymes are known to be important factors in cell physiology both in terms of health and disease. They are activated by triggering signals that induce their translocation to membranes. The consensus view is that several secondary messengers are involved in this activation, such as cytosolic Ca2+ and diacylglycerol. Cytosolic Ca2+ bridges the C2 domain to anionic phospholipids as phosphatidylserine in the membrane, and diacylglycerol binds to the C1 domain. Both diacylglycerol and the increase in Ca2+ concentration are assumed to arise from the extracellular signal that triggers the hydrolysis of phosphatidylinositol-4,5-bisphosphate. However, results obtained during the last decade indicate that this phosphoinositide itself is also responsible for modulating classical PKC activity and its localization in the plasma membrane.

Keywords

Protein kinase C Phosphatidylinositol-4,5-bisphosphate C2 domain Diacylglycerol C1 domain 

Notes

Acknowledgments

This work was supported by Ministerio de Economía y Competitividad (Spain), grant [BFU2011-22828], co-financed by the European Regional Development Fund and 08700/PI/08 (Fundación Seneca, Region de Murcia).

Conflict of interest

None.

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Copyright information

© International Union for Pure and Applied Biophysics (IUPAB) and Springer-Verlag Berlin Heidelberg 2013

Authors and Affiliations

  1. 1.Departamento de Bioquímica y Biología Molecular-A, Regional Campus of International Excellence “Campus Mare Nostrum”Universidad de MurciaMurciaSpain

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