Biophysical Reviews

, Volume 4, Issue 3, pp 245–253 | Cite as

Application of a systems approach to study developmental gene regulation

  • Joshua W. K. HoEmail author


All cells in a multicellular organism contain the same genome, yet different cell types express different sets of genes. Recent advances in high throughput genomic technologies have opened up new opportunities to understand the gene regulatory network in diverse cell types in a genome-wide manner. Here, I discuss recent advances in experimental and computational approaches for the study of gene regulation in embryonic development from a systems perspective. This review is written for computational biologists who have an interest in studying developmental gene regulation through integrative analysis of gene expression, chromatin landscape, and signaling pathways. I highlight the utility of publicly available data and tools, as well as some common analysis approaches.


Developmental signaling Gene regulatory network Computational biophysics ChIP-seq Histone modification Epigenomics 



This work is partially supported by the National Institutes of Health (NIH) Common Fund through National Institute of Biomedical Imagining and Bioengineering Grant RL9EB008539.

Conflict of interest

The author does not have any conflict of interest.


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Copyright information

© International Union for Pure and Applied Biophysics (IUPAB) and Springer 2012

Authors and Affiliations

  1. 1.Division of Genetics, Department of MedicineBrigham and Women’s Hospital, Harvard Medical SchoolBostonUSA

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