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SH3 domains: modules of protein–protein interactions

Abstract

Src homology 3 (SH3) domains are involved in the regulation of important cellular pathways, such as cell proliferation, migration and cytoskeletal modifications. Recognition of polyproline and a number of noncanonical sequences by SH3 domains has been extensively studied by crystallography, nuclear magnetic resonance and other methods. High-affinity peptides that bind SH3 domains are used in drug development as candidates for anticancer treatment. This review summarizes the latest achievements in deciphering structural determinants of SH3 function.

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Fig. 1
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Abbreviations

Ack-1:

Activated CDC42-associated kinase

Csk:

Carboxyl-terminal Src kinase

Fyn:

FGR and yes-related novel kinase

Hck:

Hematopoetic cell kinase

IB1:

Islet brain 1

PEP:

Proline-enriched phosphatase

PEST:

Proline/glutamic acid/serine/threonine-rich domain

PTK:

Protein tyrosine kinase

SH3:

Src homology 3

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Correspondence to Natalya Kurochkina.

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Kurochkina, N., Guha, U. SH3 domains: modules of protein–protein interactions. Biophys Rev 5, 29–39 (2013) doi:10.1007/s12551-012-0081-z

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Keywords

  • Three-dimensional structure
  • SH3 domain
  • Cell signaling
  • Src-family
  • Myosin
  • Protein conformation