Biophysical Reviews

, Volume 3, Issue 1, pp 1–13

Network modelling of gene regulation


DOI: 10.1007/s12551-010-0041-4

Cite this article as:
Ho, J.W.K. & Charleston, M.A. Biophys Rev (2011) 3: 1. doi:10.1007/s12551-010-0041-4


Gene regulatory network (GRN) modelling has gained increasing attention in the past decade. Many computational modelling techniques have been proposed to facilitate the inference and analysis of GRN. However, there is often confusion about the aim of GRN modelling, and how a gene network model can be fully utilised as a tool for systems biology. The aim of the present article is to provide an overview of this rapidly expanding subject. In particular, we review some fundamental concepts of systems biology and discuss the role of network modelling in understanding complex biological systems. Several commonly used network modelling paradigms are surveyed with emphasis on their practical use in systems biology research.


Gene regulatory network Systems biology Bioinformatics 

Copyright information

© International Union for Pure and Applied Biophysics (IUPAB) and Springer 2010

Authors and Affiliations

  1. 1.School of Information TechnologiesThe University of SydneySydneyAustralia
  2. 2.Centre for Mathematical BiologyThe University of SydneySydneyAustralia
  3. 3.Department of MedicineBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

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