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The first in vivo application of synthetic polymers based on methacrylic acid as an aflatoxin sorbent in an animal model

  • Homa Arak
  • Mohammad Amir Karimi TorshiziEmail author
  • Mehdi Hedayati
  • Shaban Rahimi
Original Article
  • 25 Downloads

Abstract

This study attempts to evaluate the potential aflatoxin binder activity of a molecularly imprinted polymer (TMU95) synthesized to target the aflatoxin B1 (AFB1) analog molecule in comparison to a commercial toxin binder (CTB). Adsorption experiments were carried out to assess the ability to bind to AFB1 at various pH values. The strength of binding was investigated by the chemisorption index. The isothermal analysis was used to determine the maximum adsorption capacity values. The ability of TMU95 and CTB to adsorb essential minerals was evaluated and the obtained data suggested that CTB would significantly reduce availability of them compared to TMU95. The in vivo efficacy of TMU95 as an aflatoxin (AF) binder in duckling exposed to aflatoxin-contaminated feed from 4 to 18 days of age in comparison to the CTB was also assessed. TMU95 and CTB were effective in reducing the adverse effects caused by AFs on feed conversion ratio of duckling (p ≤ 0.01), and also showed a minor reduction of injuries caused by AFs on visceral organs enlargement (p ≤ 0.01). It was concluded that TMU95 could absorb AFB1 in vitro efficiently and had beneficial health effects that could alleviate some of the toxic effects of AFs on growing duckling performance similar to CTB.

Keywords

Aflatoxin Duckling Isothermal analysis Moleculary imprinted polymer 

Notes

Acknowledgements

The authors would like to thank Dr. Rasoul Rahnamaie from Faculty of Agriculture, Tarbiat Modares University, for his kind assistance with the polymer and commercial toxin binder characterization.

Source of funding

This research was partially supported by Vivan Group (Mashhad, Iran).

Compliance with ethical standards

The animal use protocol was approved by the Institutional Animal Care of Tarbiat Modares University.

Conflict of interest

None.

Supplementary material

12550_2019_353_MOESM1_ESM.docx (1.2 mb)
ESM 1 (DOCX 1209 kb)

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Copyright information

© Society for Mycotoxin (Research Gesellschaft für Mykotoxinforschung e.V.) and Springer-Verlag GmbH Germany, part of Springer Nature 2019

Authors and Affiliations

  1. 1.Department of Poultry Science, Faculty of AgricultureTarbiat Modares UniversityTehranIran
  2. 2.Research Institute for Endocrine SciencesShahid Beheshti University of Medical SciencesTehranIran

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