Bone formation within the vicinity of biodegradable magnesium alloy implant in a rat femur model
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The purposes of this preliminary study were to investigate the effect of increased Ca contents (5–10 wt% Ca) in Mg-Ca alloy on the mechanical properties and osseous healing rate in a standard rat defect model. Mechanical tests were performed using a compression system followed by qualitative histological analysis using the hemotoxylin and eosin (H&E) staining method and quantitative reverse transcriptase polymerase chain reaction (reverse transcriptase PCR). Mg-Ca alloy degraded fast in vivo while displaying a high level of the bone formation markersOC and ALP. Favorablemechanical strength properties were displayed as Ca content increased from 5 wt% to 10 wt% to show its potential to be considered as a load bearing implant material. The resultfrom this study suggests that the developed Mg-Ca alloy has the potential to serve as a biocompatible load bearing implant material that is degradable and possibly osteoconductive.
Key wordsbiomaterials casting mechanical properties bone compression test
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- 6.A. Lambotte, Bull. Mem. Soc. Nat. Chir. 28, 1325 (1932).Google Scholar
- 7.V. V. Troitskii and D. N. Tsitrin, Khirurgiia 8, 41 (1944).Google Scholar
- 16.G. D. Zhang, J. J. Huang, K. Yang, B. C. Yang, and H. J. Ai, Acta. Metall. Sinica. 43, 1186 (2007).Google Scholar
- 22.I. J. Shon, H. S. Kang, K. T. Hong, J. M. Doh, and J. K. Yoon, Korean J. Met. Mater. 49, 614 (2011).Google Scholar
- 23.J. Z. Ilich and J. E. Kerstetter, J. Am. Coll. Nutr. 19, 715 (2000).Google Scholar