Metals and Materials International

, Volume 18, Issue 2, pp 243–247 | Cite as

Bone formation within the vicinity of biodegradable magnesium alloy implant in a rat femur model

  • Hyung-Seop Han
  • Young-Yul Kim
  • Yu-Chan Kim
  • Sung-Youn Cho
  • Pil-Ryung Cha
  • Hyun-Kwang SeokEmail author
  • Seok-Jo YangEmail author


The purposes of this preliminary study were to investigate the effect of increased Ca contents (5–10 wt% Ca) in Mg-Ca alloy on the mechanical properties and osseous healing rate in a standard rat defect model. Mechanical tests were performed using a compression system followed by qualitative histological analysis using the hemotoxylin and eosin (H&E) staining method and quantitative reverse transcriptase polymerase chain reaction (reverse transcriptase PCR). Mg-Ca alloy degraded fast in vivo while displaying a high level of the bone formation markersOC and ALP. Favorablemechanical strength properties were displayed as Ca content increased from 5 wt% to 10 wt% to show its potential to be considered as a load bearing implant material. The resultfrom this study suggests that the developed Mg-Ca alloy has the potential to serve as a biocompatible load bearing implant material that is degradable and possibly osteoconductive.

Key words

biomaterials casting mechanical properties bone compression test 


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Copyright information

© The Korean Institute of Metals and Materials and Springer Netherlands 2012

Authors and Affiliations

  • Hyung-Seop Han
    • 1
  • Young-Yul Kim
    • 2
  • Yu-Chan Kim
    • 3
  • Sung-Youn Cho
    • 4
  • Pil-Ryung Cha
    • 5
  • Hyun-Kwang Seok
    • 3
    Email author
  • Seok-Jo Yang
    • 1
    Email author
  1. 1.Department of Mechatronics EngineeringChungnam National UniversityDaejeonKorea
  2. 2.Department of Orthopedic SurgeryThe Catholic UniversityDaejeonKorea
  3. 3.Biomedical Research InstituteKorea Institute of Science & TechnologySeoulKorea
  4. 4.Department of Mechanical EngineeringKorea UniversitySeoulKorea
  5. 5.School of Advanced Materials EngineeringKookmin UniversitySeoulKorea

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