Electromagnetic detection of HIV DNA in the blood of AIDS patients treated by antiretroviral therapy
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Electromagnetic signals of low frequency have been shown to be durably produced in aqueous dilutions of the Human Imunodeficiency Virus DNA. In vivo, HIV DNA signals are detected only in patients previously treated by antiretroviral therapy and having no detectable viral RNA copies in their blood. We suggest that the treatment of AIDS patients pushes the virus towards a new mode of replication implying only DNA, thus forming a reservoir insensitive to retroviral inhibitors. Implications for new approaches aimed at eradicating HIV infection are discussed.
Key wordsHIV DNA antiretroviral therapy HIV reservoir HIV LTR detection HIV DNA with erythrocyte fraction
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- Meyerhans, A., Breinig, T., Vartanian, J.-P., Wain-Hobson, S. 2003. Forms and function of intracellular HIV DNA. Theoretical Biology and Biophysics Group, Los Alamos National Laboratory, LA-UR number 04-7420.Google Scholar
- Montagnier, L., Lavallée, C. 2007. Sensitive detection of bacteria by improved nested polymerase chain reaction targeting the 16S ribosomal RNA gene and identification of bacterial species by amplicon sequencing. US Patent No WO 2007/011367 A2.Google Scholar
- Sharkey, M.E., Teo, I., Greenough, T., Sharova, N., Luzuriaga, K., Sullivan, J.L., Bucy, R.P., Kostrikis, L.G., Haase, A., Veryard, C., Davaro, R.E., Cheeseman, S.H., Daly, J.S., Bova, C., Ellison, R.T. 3rd, Mady, B., Lai, K.K., Moyle, G., Nelson, M., Gazzard, B., Shaunak, S., Stevenson, M. 2000. Persistence of episomal HIV-1 infection intermediates in patients on highly active anti-retroviral therapy. Nat Med 6, 76–81.CrossRefPubMedGoogle Scholar
- Zuniga, J.M., Whiteside, A., Ghaziani, A., Bartlett, J.G. 2008. A decade of HAART. In: The development and global impact of highly active antiretroviral therapy. Oxford University Press.Google Scholar