International Journal of Behavioral Medicine

, Volume 19, Issue 4, pp 403–488 | Cite as

Open image in new windowEuropean Guidelines on Cardiovascular Disease Prevention in Clinical Practice (Version 2012)

The Fifth Joint Task Force of the European Society of Cardiology and Other Societies on Cardiovascular Disease Prevention in Clinical Practice (Constituted by Representatives of Nine Societies and by Invited Experts)
  • Joep Perk
  • Guy De Backer
  • Helmut Gohlke
  • Ian Graham
  • Željko Reiner
  • W. M. Monique Verschuren
  • Christian Albus
  • Pascale Benlian
  • Gudrun Boysen
  • Renata Cifkova
  • Christi Deaton
  • Shah Ebrahim
  • Miles Fisher
  • Giuseppe Germano
  • Richard Hobbs
  • Arno Hoes
  • Sehnaz Karadeniz
  • Alessandro Mezzani
  • Eva Prescott
  • Lars Ryden
  • Martin Scherer
  • Mikko Syvänne
  • Wilma J. M. Scholte Op Reimer
  • Christiaan Vrints
  • David Wood
  • Jose Luis Zamorano
  • Faiez Zannad
  • Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)
Joint Societies Guidelines

Keywords

Cardiovascular disease Prevention Risk assessment Risk management Smoking Nutrition Physical activity Psychosocial factors 

Abbreviations and acronyms

ABI

ankle–brachial index

ACCORD

Action to Control Cardiovascular Risk in Diabetes

ADVANCE

Action in Diabetes and Vascular Disease: Preterax and Diamicron Modified Release Controlled Evaluation

AGREE

Appraisal of Guidelines Research and Evaluation

AHA

American Heart Association

apoA1

apolipoprotein A1

apoB

apolipoprotein B

CABG

coronary artery bypass graft surgery

CARDS

Collaborative AtoRvastatin Diabetes Study

CCNAP

Council on Cardiovascular Nursing and Allied Professions

CHARISMA

Clopidogrel for High Athero-thrombotic Risk and Ischemic Stabilisation, Management, and Avoidance

CHD

coronary heart disease

CKD

chronic kidney disease

COMMIT

Clopidogrel and Metoprolol in Myocardial Infarction Trial

CRP

C-reactive protein

CURE

Clopidogrel in Unstable Angina to Prevent Recurrent Events

CVD

cardiovascular disease

DALYs

disability-adjusted life years

DBP

diastolic blood pressure

DCCT

Diabetes Control and Complications Trial

ED

erectile dysfunction

eGFR

estimated glomerular filtration rate

EHN

European Heart Network

EPIC

European Prospective Investigation into Cancer and Nutrition

EUROASPIRE

European Action on Secondary and Primary Prevention through Intervention to Reduce Events

GFR

glomerular filtration rate

GOSPEL

Global Secondary Prevention Strategies to Limit Event Recurrence After MI

GRADE

Grading of Recommendations Assessment, Development and Evaluation

HbA1c

glycated haemoglobin

HDL

high-density lipoprotein

HF-ACTION

Heart Failure and A Controlled Trial Investigating Outcomes of Exercise TraiNing

HOT

Hypertension Optimal Treatment Study

HPS

Heart Protection Study

HR

hazard ratio

hsCRP

high-sensitivity C-reactive protein

HYVET

Hypertension in the Very Elderly Trial

ICD

International Classification of Diseases

IMT

intima-media thickness

INVEST

International Verapamil SR/Trandolapril

JTF

Joint Task Force

LDL

low-density lipoprotein

Lp(a)

lipoprotein(a)

LpPLA2

lipoprotein-associated phospholipase 2

LVH

left ventricular hypertrophy

MATCH

Management of Atherothrombosis with Clopidogrel in High-risk Patients with Recent Transient Ischaemic Attack or Ischaemic Stroke

MDRD

Modification of Diet in Renal Disease

MET

metabolic equivalent

MONICA

Multinational MONItoring of trends and determinants in CArdiovascular disease

NICE

National Institute of Health and Clinical Excellence

NRT

nicotine replacement therapy

NSTEMI

non-ST elevation myocardial infarction

ONTARGET

Ongoing Telmisartan Alone and in combination with Ramipril Global Endpoint Trial

OSA

obstructive sleep apnoea

PAD

peripheral artery disease

PCI

percutaneous coronary intervention

PROactive

Prospective Pioglitazone Clinical Trial in Macrovascular Events

PWV

pulse wave velocity

QOF

Quality and Outcomes Framework

RCT

randomized clinical trial

RR

relative risk

SBP

systolic blood pressure

SCORE

Systematic Coronary Risk Evaluation Project

SEARCH

Study of the Effectiveness of Additional Reductions in Cholesterol and

SHEP

Systolic Hypertension in the Elderly Program

STEMI

ST-elevation myocardial infarction

SU.FOL.OM3

SUpplementation with FOlate, vitamin B6 and B12 and/or OMega-3 fatty acids

Syst-Eur

Systolic Hypertension in Europe

TNT

Treating to New Targets

UKPDS

United Kingdom Prospective Diabetes Study

VADT

Veterans Affairs Diabetes Trial

VALUE

Valsartan Antihypertensive Long-term Use

VITATOPS

VITAmins TO Prevent Stroke

VLDL

very low-density lipoprotein

WHO

World Health Organization

Notes

Disclaimer

The ESC Guidelines represent the views of the ESC and were arrived at after careful consideration of the available evidence at the time they were written. Health professionals are encouraged to take them fully into account when exercising their clinical judgement. The guidelines do not, however, override the individual responsibility of health professionals to make appropriate decisions in the circumstances of the individual patients, in consultation with that patient, and where appropriate and necessary the patient’s guardian or carer. It is also the health professional’s responsibility to verify the rules and regulations applicable to drugs and devices at the time of prescription.

The disclosure forms of the authors and reviewers are available on the ESC website www.escardio.org/guidelines & The European Society of Cardiology 2012. All rights reserved. For permissions please email: journals.permissions@oxfordjournals.org

References

  1. 1.
    SIGN (Scottish Intercollegiate Guidelines Network). Risk Estimation and the Prevention of Cardiovascular Disease. A National Clinical Guideline. 2007. Report No. 97. http://www.sign.ac.uk/pdf/sign97.pdf
  2. 2.
    World Health Organization. Joint WHO/FAO Expert Consultation on Diet, Nutrition and the Prevention of Chronic Diseases. 2002. Report No. 916.Google Scholar
  3. 3.
    Last JM, editor. A dictionary of epidemiology. 4th ed. New York: Oxford University Press; 2001.Google Scholar
  4. 4.
    Ferket BS, Colkesen EB, Visser JJ, Spronk S, Kraaijenhagen RA, Steyerberg EW, et al. Systematic review of guidelines on cardiovascular risk assessment: which recommendations should clinicians follow for a cardiovascular health check? Arch Intern Med. 2010;170:27–40.PubMedCrossRefGoogle Scholar
  5. 5.
    Kotseva K, Wood D, De Backer G, De Bacquer D, Pyorala K, Keil U. Cardiovascular prevention guidelines in daily practice: a comparison of EUROASPIRE I, II, and III surveys in eight European countries. Lancet. 2009;373:929–40.PubMedCrossRefGoogle Scholar
  6. 6.
    O’Kelly S, Ryden L. The political power of heart doctors: with the European Heart Health Charter towards a European policy on cardiovascular disease. Eur J Cardiovasc Prev Rehabil. 2009;16 Suppl 2:S58–60.PubMedGoogle Scholar
  7. 7.
    Woolf SH, Dickey LL. Differing perspectives on preventive care guidelines: a new look at the mammography controversy. Am J Prev Med. 1999;17:260–8.PubMedCrossRefGoogle Scholar
  8. 8.
    Grol R, Dalhuijsen J, Thomas S, Veld C, Rutten G, Mokkink H. Attributes of clinical guidelines that influence use of guidelines in general practice: observational study. BMJ. 1998;317:858–61.PubMedCrossRefGoogle Scholar
  9. 9.
    Guyatt GH, Oxman AD, Vist GE, Kunz R, Falck-Ytter Y, Alonso-Coello P, et al. GRADE: an emerging consensus on rating quality of evidence strength of recommendations. BMJ. 2008;336:924–6.PubMedCrossRefGoogle Scholar
  10. 10.
    Guyatt GH, Oxman AD, Kunz R, Vist GE, Falck-Ytter Y, Schunemann HJ. What is ‘quality of evidence’ and why is it important to clinicians? BMJ. 2008;336:995–8.PubMedCrossRefGoogle Scholar
  11. 11.
    Schunemann HJ, Oxman AD, Brozek J, Glasziou P, Jaeschke R, Vist GE, et al. Grading quality of evidence and strength of recommendations for diagnostic tests and strategies. BMJ. 2008;336:1106–10.PubMedCrossRefGoogle Scholar
  12. 12.
    World Health Organization, Regional Office for Europe. The prevention and control of major cardiovascular diseases. Report of a Conference. 1973. Report No. Euro 8214.Google Scholar
  13. 13.
    Mirzaei M, Truswell AS, Taylor R, Leeder SR. Coronary heart disease epidemics: not all the same. Heart. 2009;95:740–6.PubMedCrossRefGoogle Scholar
  14. 14.
    European Heart Network. European Cardiovascular Disease Statistics. 2008 edition.Google Scholar
  15. 15.
    Levi F, Chatenoud L, Bertuccio P, Lucchini F, Negri E, La Vecchia C. Mortality from cardiovascular and cerebrovascular diseases in Europe and other areas of the world: an update. Eur J Cardiovasc Prev Rehabil. 2009;16:333–50.PubMedCrossRefGoogle Scholar
  16. 16.
    Tunstall-Pedoe H (World Health Organization). MONICA monograph and multimedia sourcebook. 2003. http://whqlibdoc.who.int/publications/2003/9241562234.pdf
  17. 17.
    Ford ES, Capewell S. Coronary heart disease mortality among young adults in the U.S. from 1980 through 2002: concealed leveling of mortality rates. J Am Coll Cardiol. 2007;50:2128–32.PubMedCrossRefGoogle Scholar
  18. 18.
    Vander Stichele C, De Bacquer D, De Henauw S, Vannoote P, Gevaert S, Populier N, et al. Is the decline in coronary attack rates leveling off in Flanders? Eur J Cardiovasc Prev Rehabil. 2008;15 suppl 1:S1–S31.Google Scholar
  19. 19.
    Rose G. Sick individuals and sick populations. Int J Epidemiol. 1985;14:32–8.PubMedCrossRefGoogle Scholar
  20. 20.
    Manuel DG, Lim J, Tanuseputro P, Anderson GM, Alter DA, Laupacis A, et al. Revisiting Rose: strategies for reducing coronary heart disease. BMJ. 2006;332:659–62.PubMedCrossRefGoogle Scholar
  21. 21.
    Forsen T, Eriksson JG, Tuomilehto J, Osmond C, Barker DJ. Growth in utero and during childhood among women who develop coronary heart disease: longitudinal study. BMJ. 1999;319:1403–7.PubMedCrossRefGoogle Scholar
  22. 22.
    Painter RC, de Rooij SR, Bossuyt PM, Simmers TA, Osmond C, Barker DJ, et al. Early onset of coronary artery disease after prenatal exposure to the Dutch famine. Am J Clin Nutr. 2006;84:322–7. quiz 466–327.PubMedGoogle Scholar
  23. 23.
    Vos LE, Oren A, Uiterwaal C, Gorissen WH, Grobbee DE, Bots ML. Adolescent blood pressure and blood pressure tracking into young adulthood are related to subclinical atherosclerosis: the Atherosclerosis Risk in Young Adults (ARYA) study. Am J Hypertens. 2003;16:549–55.PubMedCrossRefGoogle Scholar
  24. 24.
    Bejan-Angoulvant T, Saadatian-Elahi M, Wright JM, Schron EB, Lindholm LH, Fagard R, et al. Treatment of hypertension in patients 80 years and older: the lower the better? A meta-analysis of randomized controlled trials. J Hypertens. 2010;28:1366–72.PubMedCrossRefGoogle Scholar
  25. 25.
    Doolan DM, Froelicher ES. Smoking cessation interventions and older adults. Prog Cardiovasc Nurs. 2008;23:119–27.PubMedCrossRefGoogle Scholar
  26. 26.
    Sackett DL. Evidence-based medicine and treatment choices. Lancet. 1997;349:570. author reply 572–573.PubMedCrossRefGoogle Scholar
  27. 27.
    McGovern PG, Jacobs Jr DR, Shahar E, Arnett DK, Folsom AR, Blackburn H, et al. Trends in acute coronary heart disease mortality, morbidity, and medical care from 1985 through 1997: the Minnesota heart survey. Circulation. 2001;104:19–24.PubMedCrossRefGoogle Scholar
  28. 28.
    Fichtenberg CM, Glantz SA. Association of the California Tobacco Control Program with declines in cigarette consumption and mortality from heart disease. N Engl J Med. 2000;343:1772–7.PubMedCrossRefGoogle Scholar
  29. 29.
    Ford ES, Ajani UA, Croft JB, Critchley JA, Labarthe DR, Kottke TE, et al. Explaining the decrease in U.S. deaths from coronary disease, 1980–2000. N Engl J Med. 2007;356:2388–98.PubMedCrossRefGoogle Scholar
  30. 30.
    Di Chiara A, Vanuzzo D. Does surveillance impact on cardiovascular prevention? Eur Heart J. 2009;30:1027–9.PubMedCrossRefGoogle Scholar
  31. 31.
    Capewell S, O’Flaherty M. Rapid mortality falls after risk-factor changes in populations. Lancet. 2011;378:752–3.PubMedCrossRefGoogle Scholar
  32. 32.
    National Institute for Health and Clinical Excellence. Prevention of Cardiovascular Disease: Costing Report. 2010. Nice Public Health Guidance 25. http://www.nice.org.uk/nicemedia/live/13024/49325/49325.pdf
  33. 33.
    Kotseva K, Wood D, De Backer G, De Bacquer D, Pyorala K, Keil U. EUROASPIRE III: a survey on the lifestyle, risk factors and use of cardioprotective drug therapies in coronary patients from 22 European countries. Eur J Cardiovasc Prev Rehabil. 2009;16:121–37.PubMedCrossRefGoogle Scholar
  34. 34.
    Kotseva K, Wood D, De Backer G, De Bacquer D, Pyorala K, Reiner Z, et al. EUROASPIRE III. Management of cardiovascular risk factors in asymptomatic high-risk patients in general practice: cross-sectional survey in 12 European countries. Eur J Cardiovasc Prev Rehabil. 2010;17:530–40.PubMedCrossRefGoogle Scholar
  35. 35.
    Wood DA, Kotseva K, Connolly S, Jennings C, Mead A, Jones J, et al. Nurse-coordinated multidisciplinary, familybased cardiovascular disease prevention programme (EUROACTION) for patients with coronary heart disease and asymptomatic individuals at high risk of cardiovascular disease: a paired, cluster-randomised controlled trial. Lancet. 2008;371:1999–2012.PubMedCrossRefGoogle Scholar
  36. 36.
    Mosca L, Banka CL, Benjamin EJ, Berra K, Bushnell C, Dolor RJ, et al. Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update. Circulation. 2007;115:1481–501.PubMedCrossRefGoogle Scholar
  37. 37.
    Graham I, Atar D, Borch-Johnsen K, Boysen G, Burell G, Cifkova R, et al. European guidelines on cardiovascular disease prevention in clinical practice: full text. Fourth Joint Task Force of the European Society of Cardiology and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of nine societies and by invited experts). Eur J Cardiovasc Prev Rehabil. 2007;14 Suppl 2:S1–S113.PubMedCrossRefGoogle Scholar
  38. 38.
    Pyorala K, De Backer G, Graham I, Poole-Wilson P, Wood D. Prevention of coronary heart disease in clinical practice. Recommendations of the Task Force of the European Society of Cardiology, European Atherosclerosis Society and European Society of Hypertension. Eur Heart J. 1994;15:1300–31.PubMedGoogle Scholar
  39. 39.
    EUROASPIRE II Study Group. Lifestyle and risk factor management and use of drug therapies in coronary patients from 15 countries; principal results from EUROASPIRE II Heart Survey Programme. Eur Heart J. 2001;22:554–72.CrossRefGoogle Scholar
  40. 40.
    Wood D, De Backer G, Faergeman O, Graham I, Mancia G, Pyorala K. Prevention of coronary heart disease in clinical practice: recommendations of the Second Joint Task Force of European and other Societies on Coronary Prevention. Atherosclerosis. 1998;140:199–270.PubMedCrossRefGoogle Scholar
  41. 41.
    Anderson K, Odell P, Wilson P, Kannel WB. Cardiovascular disease risk profiles. Am Heart J. 1991;121:293–8.PubMedCrossRefGoogle Scholar
  42. 42.
    Reiner Z, Catapano AL, De Backer G, Graham I, Taskinen MR, Wiklund O, et al. ESC/EAS Guidelines for the management of dyslipidaemias: The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Eur Heart J. 2011;32:1769–818.PubMedCrossRefGoogle Scholar
  43. 43.
    Marmot M. Sustainable development and the social gradient in coronary heart disease. Eur Heart J. 2001;22:740–50.PubMedCrossRefGoogle Scholar
  44. 44.
    De Backer G, Ambrosioni E, Borch-Johnsen K, Brotons C, Cifkova R, Dallongeville J, et al. European guidelines on cardiovascular disease prevention in clinical practice: Third Joint Task Force of European and other societies on cardiovascular disease prevention in clinical practice (constituted by representatives of eight societies and by invited experts). Eur J Cardiovasc Prev Rehabil. 2003;10:S1–S10.PubMedCrossRefGoogle Scholar
  45. 45.
    Conroy RM, Pyorala K, Fitzgerald AP, Sans S, Menotti A, De Backer G, et al. Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project. Eur Heart J. 2003;24:987–1003.PubMedCrossRefGoogle Scholar
  46. 46.
    Aktas MK, Ozduran V, Pothier CE, Lang R, Lauer MS. Global risk scores and exercise testing for predicting all-cause mortality in a preventive medicine program. JAMA. 2004;292:1462–8.PubMedCrossRefGoogle Scholar
  47. 47.
    Vartiainen E, Jousilahti P, Alfthan G, Sundvall J, Pietinen P, Puska P. Cardiovascular risk factor changes in Finland, 1972–1997. Int J Epidemiol. 2000;29:49–56.PubMedCrossRefGoogle Scholar
  48. 48.
    Cooney MT, Dudina A, De Bacquer D, Fitzgerald A, Conroy R, Sans S, et al. How much does HDL cholesterol add to risk estimation? A report from the SCORE Investigators. Eur J Cardiovasc Prev Rehabil. 2009;16:304–14.PubMedCrossRefGoogle Scholar
  49. 49.
    Cooney MT, Dudina A, De Bacquer D, Wilhelmsen L, Sans S, Menotti A, et al. HDL cholesterol protects against cardiovascular disease in both genders, at all ages and at all levels of risk. Atherosclerosis. 2009;206:611–6.PubMedCrossRefGoogle Scholar
  50. 50.
    Cooney M, Dudina A, Bacquer DD, Fitzgerald A, Conroy R, Sans S, et al. How much does HDL cholesterol add to risk estimation? A report from the SCORE investigators. Eur J Cardiovasc Prev Rehabil. 2009;16:304–14.PubMedCrossRefGoogle Scholar
  51. 51.
    Cooney MT, Dudina A, De Bacquer D, Wilhelmsen L, Sans S, Menotti A, De Backer G, Jousilahti P, Keil U, Thomsen T, Whincup P, Graham IM. HDL cholesterol protects against cardiovascular disease in both genders, at all ages and at all levels of risk. Atherosclerosis 2009;206:611–616.Google Scholar
  52. 52.
    Di Angelantonio E, Sarwar N, Perry P, Kaptoge S, Ray KK, Thompson A, et al. Major lipids, apolipoproteins, and risk of vascular disease. JAMA. 2009;302:1993–2000.PubMedCrossRefGoogle Scholar
  53. 53.
    Ridker PM. Fasting versus nonfasting triglycerides and the prediction of cardiovascular risk: do we need to revisit the oral triglyceride tolerance test? Clin Chem. 2008;54:11–3.PubMedCrossRefGoogle Scholar
  54. 54.
    Abdel-Maksoud MF, Hokanson JE. The complex role of triglycerides in cardiovascular disease. Semin Vasc Med. 2002;2:325–33.PubMedCrossRefGoogle Scholar
  55. 55.
    Sarwar N, Danesh J, Eiriksdottir G, Sigurdsson G, Wareham N, Bingham S, et al. Triglycerides and the risk of coronary heart disease: 10,158 incident cases among 262,525 participants in 29 Western prospective studies. Circulation. 2007;115:450–8.PubMedCrossRefGoogle Scholar
  56. 56.
    Cooney MT, Vartiainen E, Laatikainen T, Juolevi A, Dudina A, Graham IM. Elevated resting heart rate is an independent risk factor for cardiovascular disease in healthy men and women. Am Heart J. 2010;159:612–9. e613.PubMedCrossRefGoogle Scholar
  57. 57.
    Shaper AG, Wannamethee G, Macfarlane PW, Walker M. Heart rate ischaemic heart disease sudden cardiac death in middle-aged British men. Br Heart J. 1993;70:49–55.PubMedCrossRefGoogle Scholar
  58. 58.
    Jouven X, Empana JP, Escolano S, Buyck JF, Tafflet M, Desnos M, et al. Relation of heart rate at rest and long-term (.20 years) death rate in initially healthy middle-aged men. Am J Cardiol. 2009;103:279–83.PubMedCrossRefGoogle Scholar
  59. 59.
    Nauman J, Janszky I, Vatten LJ, Wisloff U. Temporal changes in resting heart rate and deaths from ischemic heart disease. JAMA. 2011;306:2579–87.PubMedCrossRefGoogle Scholar
  60. 60.
    Fox K, Ford I, Steg PG, Tendera M, Robertson M, Ferrari R. Heart rate as a prognostic risk factor in patients with coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a subgroup analysis of a randomised controlled trial. Lancet. 2008;372:817–21.PubMedCrossRefGoogle Scholar
  61. 61.
    Diaz A, Bourassa MG, Guertin MC, Tardif JC. Long-term prognostic value of resting heart rate in patients with suspected or proven coronary artery disease. Eur Heart J. 2005;26:967–74.PubMedCrossRefGoogle Scholar
  62. 62.
    Freemantle N, Cleland J, Young P, Mason J, Harrison J. beta Blockade after myocardial infarction: systematic review and meta regression analysis. BMJ. 1999;318:1730–7.PubMedCrossRefGoogle Scholar
  63. 63.
    Brophy JM, Joseph L, Rouleau JL. Beta-blockers in congestive heart failure. A Bayesian meta-analysis. Ann Intern Med. 2001;134:550–60.PubMedGoogle Scholar
  64. 64.
    Fox K, Ford I, Steg PG, Tendera M, Ferrari R. Ivabradine for patients with stable coronary artery disease and left-ventricular systolic dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial. Lancet. 2008;372:807–16.PubMedCrossRefGoogle Scholar
  65. 65.
    Swedberg K, Komajda M, Bohm M, Borer JS, Ford I, Dubost-Brama A, et al. Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebocontrolled study. Lancet. 2010;376:875–85.PubMedCrossRefGoogle Scholar
  66. 66.
    Wilson P, Pencina M, Jacques P, Selhub J, D’Agostino R, O’Donnell C. C-reactive protein reclassification of cardiovascular risk in the Framingham Heart Study. Circulation Cardiovasc Qual Outcomes. 2008;1:92–7.CrossRefGoogle Scholar
  67. 67.
    Cooney MT Vartiainen E, Laatikainen T, DeBacquer D, McGorrian CM, Dudina A, Graham IM, on behalf of the SCORE and FINRISK investigators. Cardiovascular risk age: Concepts and practicalities. Heart 2012;98:941–946.PubMedCrossRefGoogle Scholar
  68. 68.
    Cuende JI, Cuende N, Calaveras-Lagartos J. How to calculate vascular age with the SCORE project scales: a new method of cardiovascular risk evaluation. Eur Heart J 2010;31:2351–2358.PubMedCrossRefGoogle Scholar
  69. 69.
    World Health Organization. Global Health Observatory Data Repository. http://apps.who.int/ghodata/
  70. 70.
    Catapano AL, Reiner Z, De Backer G, Graham I, Taskinen MR, Wiklund O, et al. ESC/EAS Guidelines for the management of dyslipidaemias. The Task Force for the management of dyslipidaemias of the European Society of Cardiology (ESC) and the European Atherosclerosis Society (EAS). Atherosclerosis. 2011;217 Suppl 1:1–44.PubMedGoogle Scholar
  71. 71.
    Botkin JR. Informed consent for genetic research. Curr Protoc Hum Genet 2010;Chapter 1:Unit 1 16.Google Scholar
  72. 72.
    Paynter NP, Chasman DI, Pare G, Buring JE, Cook NR, Miletich JP, et al. Association between a literature-based genetic risk score and cardiovascular events in women. JAMA. 2010;303:631–7.PubMedCrossRefGoogle Scholar
  73. 73.
    Williams RR, Hunt SC, Heiss G, Province MA, Bensen JT, Higgins M, et al. Usefulness of cardiovascular family history data for populationbased preventive medicine and medical research (the Health Family Tree Study and the NHLBI Family Heart Study). Am J Cardiol. 2001;87:129–35.PubMedCrossRefGoogle Scholar
  74. 74.
    Botkin JR, Teutsch SM, Kaye CI, Hayes M, Haddow JE, Bradley LA, et al. Outcomes of interest in evidence-based evaluations of genetic tests. Genet Med. 2010;12:228–35.PubMedCrossRefGoogle Scholar
  75. 75.
    Huijgen R, Kindt I, Verhoeven SB, Sijbrands EJ, Vissers MN, Kastelein JJ, et al. Two years after molecular diagnosis of familial hypercholesterolemia: majority on cholesterol-lowering treatment but a minority reaches treatment goal. PLoS One. 2010;5:e9220.PubMedCrossRefGoogle Scholar
  76. 76.
    Jousilahti P, Vartiainen E, Tuomilehto J, Puska P. Sex, age, cardiovascular risk factors, and coronary heart disease: a prospective follow-up study of 14 786 middle-aged men and women in Finland. Circulation. 1999;99:1165–72.PubMedCrossRefGoogle Scholar
  77. 77.
    Rayner M, Allender S, Scarborough P. Cardiovascular disease in Europe. Eur J Cardiovasc Prev Rehabil. 2009;16 Suppl 2:S43–7.PubMedGoogle Scholar
  78. 78.
    Wald NJ, Law MR. A strategy to reduce cardiovascular disease by more than 80 %. BMJ. 2003;326:1419.PubMedCrossRefGoogle Scholar
  79. 79.
    Schisterman EF, Whitcomb BW. Coronary age as a risk factor in the modified Framingham risk score. BMC Med Imaging. 2004;4:1.PubMedCrossRefGoogle Scholar
  80. 80.
    Weintraub WS, Diamond GA. Predicting cardiovascular events with coronary calcium scoring. N Engl J Med. 2008;358:1394–6.PubMedCrossRefGoogle Scholar
  81. 81.
    Lawlor DA, Ebrahim S, Davey Smith G. Sex matters: secular, geographical trends in sex differences in coronary heart disease mortality. BMJ. 2001;323:541–5.PubMedCrossRefGoogle Scholar
  82. 82.
    Mosca L, Benjamin EJ, Berra K, Bezanson JL, Dolor RJ, Lloyd-Jones DM, et al. Effectiveness-based guidelines for the prevention of cardiovascular disease in women—2011 update: a guideline from the American Heart Association. Circulation. 2011;123:1243–62.PubMedCrossRefGoogle Scholar
  83. 83.
    Hsia J, Rodabough RJ, Manson JE, Liu S, Freiberg MS, Graettinger W, et al. Evaluation of the American Heart Association cardiovascular disease prevention guideline for women. Circ Cardiovasc Qual Outcomes. 2010;3:128–34.PubMedCrossRefGoogle Scholar
  84. 84.
    Rollman BL, Belnap BH, LeMenager MS, Mazumdar S, Houck PR, Counihan PJ, et al. Telephone-delivered collaborative care for treating post-CABG depression: a randomized controlled trial. JAMA. 2009;302:2095–103.PubMedCrossRefGoogle Scholar
  85. 85.
    Davidson KW, Rieckmann N, Clemow L, Schwartz JE, Shimbo D, Medina V, et al. Enhanced depression care for patients with acute coronary syndrome and persistent depressive symptoms: coronary psychosocial evaluation studies randomized controlled trial. Arch Intern Med. 2010;170:600–8.PubMedCrossRefGoogle Scholar
  86. 86.
    Katon WJ, Lin EH, Von Korff M, Ciechanowski P, Ludman EJ, Young B, et al. Collaborative care for patients with depression and chronic illnesses. N Engl J Med. 2010;363:2611–20.PubMedCrossRefGoogle Scholar
  87. 87.
    Woodward M, Brindle P, Tunstall-Pedoe H. Adding social deprivation and family history to cardiovascular risk assessment: the ASSIGN score from the Scottish Heart Health Extended Cohort (SHHEC). Heart. 2007;93:172–6.PubMedCrossRefGoogle Scholar
  88. 88.
    Stringhini S, Sabia S, Shipley M, Brunner E, Nabi H, Kivimaki M, et al. Association of socioeconomic position with health behaviors and mortality. JAMA. 2010;303:1159–66.PubMedCrossRefGoogle Scholar
  89. 89.
    Tonne C, Schwartz J, Mittleman M, Melly S, Suh H, Goldberg R. Long-term survival after acute myocardial infarction is lower in more deprived neighborhoods. Circulation. 2005;111:3063–70.PubMedCrossRefGoogle Scholar
  90. 90.
    Albert MA, Glynn RJ, Buring J, Ridker PM. Impact of traditional and novel risk factors on the relationship between socioeconomic status and incident cardiovascular events. Circulation. 2006;114:2619–26.PubMedCrossRefGoogle Scholar
  91. 91.
    Rahimi AR, Spertus JA, Reid KJ, Bernheim SM, Krumholz HM. Financial barriers to health care and outcomes after acute myocardial infarction. JAMA. 2007;297:1063–72.PubMedCrossRefGoogle Scholar
  92. 92.
    Mookadam F, Arthur HM. Social support and its relationship to morbidity and mortality after acute myocardial infarction: systematic overview. Arch Intern Med. 2004;164:1514–8.PubMedCrossRefGoogle Scholar
  93. 93.
    Lett HS, Blumenthal JA, Babyak MA, Strauman TJ, Robins C, Sherwood A. Social support and coronary heart disease: epidemiologic evidence and implications for treatment. Psychosom Med. 2005;67:869–78.PubMedCrossRefGoogle Scholar
  94. 94.
    Eller NH, Netterstrom B, Gyntelberg F, Kristensen TS, Nielsen F, Steptoe A, et al. Work-related psychosocial factors and the development of ischemic heart disease: a systematic review. Cardiol Rev. 2009;17:83–97.PubMedCrossRefGoogle Scholar
  95. 95.
    De Vogli R, Ferrie JE, Chandola T, Kivimaki M, Marmot MG. Unfairness and health: evidence from the Whitehall II Study. J Epidemiol Community Health. 2007;61:513–8.PubMedCrossRefGoogle Scholar
  96. 96.
    Eaker ED, Sullivan LM, Kelly-Hayes M, D’Agostino Sr RB, Benjamin EJ. Marital status, marital strain, and risk of coronary heart disease or total mortality: the Framingham Offspring Study. Psychosom Med. 2007;69:509–13.PubMedCrossRefGoogle Scholar
  97. 97.
    Orth-Gomer K, Wamala SP, Horsten M, Schenck-Gustafsson K, Schneiderman N, Mittleman MA. Marital stress worsens prognosis in women with coronary heart disease: the Stockholm Female Coronary Risk Study. JAMA. 2000;284:3008–14.PubMedCrossRefGoogle Scholar
  98. 98.
    Rugulies R. Depression as a predictor for coronary heart disease. a review and meta-analysis. Am J Prev Med. 2002;23:51–61.PubMedCrossRefGoogle Scholar
  99. 99.
    Wulsin LR, Singal BM. Do depressive symptoms increase the risk for the onset of coronary disease? A systematic quantitative review. Psychosom Med. 2003;65:201–10.PubMedCrossRefGoogle Scholar
  100. 100.
    Nicholson A, Kuper H, Hemingway H. Depression as an aetiologic and prognostic factor in coronary heart disease: a meta-analysis of 6362 events among 146 538 participants in 54 observational studies. Eur Heart J. 2006;27:2763–74.PubMedCrossRefGoogle Scholar
  101. 101.
    Barth J, Schumacher M, Herrmann-Lingen C. Depression as a risk factor for mortality in patients with coronary heart disease: a meta-analysis. Psychosom Med. 2004;66:802–13.PubMedCrossRefGoogle Scholar
  102. 102.
    van Melle JP, de Jonge P, Spijkerman TA, Tijssen JG, Ormel J, van Veldhuisen DJ, et al. Prognostic association of depression following myocardial infarction with mortality and cardiovascular events: a meta-analysis. Psychosom Med. 2004;66:814–22.PubMedCrossRefGoogle Scholar
  103. 103.
    Frasure-Smith N, Lesperance F, Gravel G, Masson A, Juneau M, Talajic M, et al. Social support, depression, mortality during the first year after myocardial infarction. Circulation. 2000;101:1919–24.PubMedCrossRefGoogle Scholar
  104. 104.
    Horsten M, Mittleman MA, Wamala SP, Schenck-Gustafsson K, Orth-Gomer K. Depressive symptoms and lack of social integration in relation to prognosis of CHD in middle-aged women. The Stockholm Female Coronary Risk Study. Eur Heart J. 2000;21:1072–80.PubMedCrossRefGoogle Scholar
  105. 105.
    Smoller JW, Pollack MH, Wassertheil-Smoller S, Jackson RD, Oberman A, Wong ND, et al. Panic attacks and risk of incident cardiovascular events among postmenopausal women in the Women’s Health Initiative Observational Study. Arch Gen Psychiatry. 2007;64:1153–60.PubMedCrossRefGoogle Scholar
  106. 106.
    Chen YH, Tsai SY, Lee HC, Lin HC. Increased risk of acute myocardial infarction for patients with panic disorder: a nationwide population-based study. Psychosom Med. 2009;71:798–804.PubMedCrossRefGoogle Scholar
  107. 107.
    Frasure-Smith N, Lesperance F. Depression and anxiety as predictors of 2-year cardiac events in patients with stable coronary artery disease. Arch Gen Psychiatry. 2008;65:62–71.PubMedCrossRefGoogle Scholar
  108. 108.
    Shibeshi WA, Young-Xu Y, Blatt CM. Anxiety worsens prognosis in patients with coronary artery disease. J Am Coll Cardiol. 2007;49:2021–7.PubMedCrossRefGoogle Scholar
  109. 109.
    Szekely A, Balog P, Benko E, Breuer T, Szekely J, Kertai MD, et al. Anxiety predicts mortality and morbidity after coronary artery and valve surgery—a 4-year follow-up study. Psychosom Med. 2007;69:625–31.PubMedCrossRefGoogle Scholar
  110. 110.
    Meyer T, Buss U, Herrmann-Lingen C. Role of cardiac disease severity in the predictive value of anxiety for all-cause mortality. Psychosom Med. 2010;72:9–15.PubMedCrossRefGoogle Scholar
  111. 111.
    Roest AM, Martens EJ, de Jonge P, Denollet J. Anxiety and risk of incident coronary heart disease: a meta-analysis. J Am Coll Cardiol. 2010;56:38–46.PubMedCrossRefGoogle Scholar
  112. 112.
    Roest AM, Martens EJ, Denollet J, de Jonge P. Prognostic association of anxiety post myocardial infarction with mortality and new cardiac events: a meta-analysis. Psychosom Med. 2010;72:563–9.PubMedCrossRefGoogle Scholar
  113. 113.
    Chida Y, Steptoe A. The association of anger and hostility with future coronary heart disease: a meta-analytic review of prospective evidence. J Am Coll Cardiol. 2009;53:936–46.PubMedCrossRefGoogle Scholar
  114. 114.
    Denollet J, Gidron Y, Vrints CJ, Conraads VM. Anger, suppressed anger, and risk of adverse events in patients with coronary artery disease. Am J Cardiol. 2010;105:1555–60.PubMedCrossRefGoogle Scholar
  115. 115.
    Denollet J, Schiffer AA, Spek V. A general propensity to psychological distress affects cardiovascular outcomes: evidence from research on the type D (distressed) personality profile. Circ Cardiovasc Qual Outcomes. 2010;3:546–57.PubMedCrossRefGoogle Scholar
  116. 116.
    Wamala SP, Mittleman MA, Schenck-Gustafsson K, Orth-Gomer K. Potential explanations for the educational gradient in coronary heart disease: a population-based case–control study of Swedish women. Am J Public Health. 1999;89:315–21.PubMedCrossRefGoogle Scholar
  117. 117.
    Chandola T, Britton A, Brunner E, Hemingway H, Malik M, Kumari M, et al. Work stress and coronary heart disease: what are the mechanisms? Eur Heart J. 2008;29:640–8.PubMedCrossRefGoogle Scholar
  118. 118.
    Rozanski A, Blumenthal JA, Davidson KW, Saab PG, Kubzansky L. The epidemiology, pathophysiology, and management of psychosocial risk factors in cardiac practice: the emerging field of behavioral cardiology. J Am Coll Cardiol. 2005;45:637–51.PubMedCrossRefGoogle Scholar
  119. 119.
    Whooley MA, de Jonge P, Vittinghoff E, Otte C, Moos R, Carney RM, et al. Depressive symptoms, health behaviors, and risk of cardiovascular events in patients with coronary heart disease. JAMA. 2008;300:2379–88.PubMedCrossRefGoogle Scholar
  120. 120.
    Steptoe A, Marmot M. The role of psychobiological pathways in socio-economic inequalities in cardiovascular disease risk. Eur Heart J. 2002;23:13–25.PubMedCrossRefGoogle Scholar
  121. 121.
    Cohen HW, Gibson G, Alderman MH. Excess risk of myocardial infarction in patients treated with antidepressant medications: association with use of tricyclic agents. Am J Med. 2000;108:2–8.PubMedCrossRefGoogle Scholar
  122. 122.
    Hippisley-Cox J, Pringle M, Hammersley V, Crown N, Wynn A, Meal A, et al. Antidepressants as risk factor for ischaemic heart disease: case–control study in primary care. BMJ. 2001;323:666–9.PubMedCrossRefGoogle Scholar
  123. 123.
    Albus C, Jordan J, Herrmann-Lingen C. Screening for psychosocial risk factors in patients with coronary heart disease—recommendations for clinical practice. Eur J Cardiovasc Prev Rehabil. 2004;11:75–9.PubMedCrossRefGoogle Scholar
  124. 124.
    Thombs BD, de Jonge P, Coyne JC, Whooley MA, Frasure-Smith N, Mitchell AJ, et al. Depression screening and patient outcomes in cardiovascular care: a systematic review. JAMA. 2008;300:2161–71.PubMedCrossRefGoogle Scholar
  125. 125.
    Berger JS, Jordan CO, Lloyd-Jones D, Blumenthal RS. Screening for cardiovascular risk in asymptomatic patients. J Am Coll Cardiol. 2010;55:1169–77.PubMedCrossRefGoogle Scholar
  126. 126.
    Kaptoge S, Di Angelantonio E, Lowe G, Pepys MB, Thompson SG, Collins R, et al. C-reactive protein concentration and risk of coronary heart disease, stroke, and mortality: an individual participant meta-analysis. Lancet. 2010;375:132–40.PubMedCrossRefGoogle Scholar
  127. 127.
    Kaptoge S, White IR, Thompson SG, Wood AM, Lewington S, Lowe GD, et al. Associations of plasma fibrinogen levels with established cardiovascular disease risk factors, inflammatory markers, and other characteristics: individual participant meta-analysis of 154,211 adults in 31 prospective studies: the fibrinogen studies collaboration. Am J Epidemiol. 2007;166:867–79.PubMedCrossRefGoogle Scholar
  128. 128.
    Clarke R, Halsey J, Lewington S, Lonn E, Armitage J, Manson JE, et al. Effects of lowering homocysteine levels with B vitamins on cardiovascular disease, cancer, and cause-specific mortality: meta-analysis of 8 randomized trials involving 37 485 individuals. Arch Intern Med. 2010;170:1622–31.PubMedCrossRefGoogle Scholar
  129. 129.
    Garza CA, Montori VM, McConnell JP, Somers VK, Kullo IJ, Lopez-Jimenez F. Association between lipoprotein-associated phospholipase A2 and cardiovascular disease: a systematic review. Mayo Clin Proc. 2007;82:159–65.PubMedGoogle Scholar
  130. 130.
    O’Leary DH, Polak JF, Kronmal RA, Manolio TA, Burke GL, Wolfson Jr SK. Carotid-artery intima and media thickness as a risk factor for myocardial infarction and stroke in older adults. Cardiovascular Health Study Collaborative Research Group. N Engl J Med. 1999;340:14–22.PubMedCrossRefGoogle Scholar
  131. 131.
    Chambless LE, Heiss G, Folsom AR, Rosamond W, Szklo M, Sharrett AR, et al. Association of coronary heart disease incidence with carotid arterial wall thickness and major risk factors: the Atherosclerosis Risk in Communities (ARIC) Study, 1987–1993. Am J Epidemiol. 1997;146:483–94.PubMedCrossRefGoogle Scholar
  132. 132.
    Sramek A, Bosch JG, Reiber JH, Van Oostayen JA, Rosendaal FR. Ultrasound assessment of atherosclerotic vessel wall changes: reproducibility of intima-media thickness measurements in carotid and femoral arteries. Invest Radiol. 2000;35:699–706.PubMedCrossRefGoogle Scholar
  133. 133.
    Hiatt WR. Medical treatment of peripheral arterial disease and claudication. N Engl J Med. 2001;344:1608–21.PubMedCrossRefGoogle Scholar
  134. 134.
    McDermott MM, Greenland P, Liu K, Guralnik JM, Celic L, Criqui MH, et al. The ankle brachial index is associated with leg function and physical activity: the Walking and Leg Circulation Study. Ann Intern Med. 2002;136:873–83.PubMedGoogle Scholar
  135. 135.
    Vogt MT, Cauley JA, Newman AB, Kuller LH, Hulley SB. Decreased ankle/arm blood pressure index and mortality in elderly women. JAMA. 1993;270:465–9.PubMedCrossRefGoogle Scholar
  136. 136.
    Schiffrin EL, Lipman ML, Mann JF. Chronic kidney disease: effects on the cardiovascular system. Circulation. 2007;116:85–97.PubMedCrossRefGoogle Scholar
  137. 137.
    van Werkhoven JM, Gaemperli O, Schuijf JD, Jukema JW, Kroft LJ, Leschka S, et al. Multislice computed tomography coronary angiography for risk stratification in patients with an intermediate pretest likelihood. Heart. 2009;95:1607–11.PubMedCrossRefGoogle Scholar
  138. 138.
    Mollmann H, Liebetrau C, Nef HM, Hamm CW. The Swedish paradox: or is there really no gender difference in acute coronary syndromes? Eur Heart J. 2011;32:3070–2.PubMedCrossRefGoogle Scholar
  139. 139.
    Gibbons RJ, Abrams J, Chatterjee K, Daley J, Deedwania PC, Douglas JS, et al. ACC/AHA 2002 guideline update for the management of patients with chronic stable angina—summary article: a report of the American College of Cardiology/American Heart Association Task Force on Practice Guidelines (Committee on the Management of Patients With Chronic Stable Angina). Circulation. 2003;107:149–58.PubMedCrossRefGoogle Scholar
  140. 140.
    Kodama S, Saito K, Tanaka S, Maki M, Yachi Y, Asumi M, et al. Cardiorespiratory fitness as a quantitative predictor of all-cause mortality and cardiovascular events in healthy men and women: a meta-analysis. JAMA. 2009;301:2024–35.PubMedCrossRefGoogle Scholar
  141. 141.
    Achenbach S, Daniel WG. Noninvasive coronary angiography—an acceptable alternative? N Engl J Med. 2001;345:1909–10.PubMedCrossRefGoogle Scholar
  142. 142.
    van Geuns RJ, Oudkerk M, Rensing BJ, Bongaerts AH, de Bruin HG, Wielopolski PA, et al. Comparison of coronary imaging between magnetic resonance imaging and electron beam computed tomography. Am J Cardiol. 2002;90:58–63.PubMedCrossRefGoogle Scholar
  143. 143.
    Miao C, Chen S, Macedo R, Lai S, Liu K, Li D, et al. Positive remodeling of the coronary arteries detected by magnetic resonance imaging in an asymptomatic population: MESA (Multi-Ethnic Study of Atherosclerosis). J Am Coll Cardiol. 2009;53:1708–15.PubMedCrossRefGoogle Scholar
  144. 144.
    Shinnar M, Fallon JT, Wehrli S, Levin M, Dalmacy D, Fayad ZA, et al. The diagnostic accuracy of ex vivo MRI for human atherosclerotic plaque characterization. Arterioscler Thromb Vasc Biol. 1999;19:2756–61.PubMedCrossRefGoogle Scholar
  145. 145.
    Kim WY, Stuber M, Bornert P, Kissinger KV, Manning WJ, Botnar RM. Three-dimensional black-blood cardiac magnetic resonance coronary vessel wall imaging detects positive arterial remodeling in patients with nonsignificant coronary artery disease. Circulation. 2002;106:296–9.PubMedCrossRefGoogle Scholar
  146. 146.
    Greenland P, Abrams J, Aurigemma GP, Bond MG, Clark LT, Criqui MH, et al. Prevention Conference V: Beyond secondary prevention: identifying the high-risk patient for primary prevention: noninvasive tests of atherosclerotic burden: Writing Group III. Circulation. 2000;101:E16–22.PubMedCrossRefGoogle Scholar
  147. 147.
    Tinana A, Mintz GS, Weissman NJ. Volumetric intravascular ultrasound quantification of the amount of atherosclerosis and calcium in nonstenotic arterial segments. Am J Cardiol. 2002;89:757–60.PubMedCrossRefGoogle Scholar
  148. 148.
    Burke AP, Kolodgie FD, Farb A, Weber D, Virmani R. Morphological predictors of arterial remodeling in coronary atherosclerosis. Circulation. 2002;105:297–303.PubMedCrossRefGoogle Scholar
  149. 149.
    Schmermund A, Schwartz RS, Adamzik M, Sangiorgi G, Pfeifer EA, Rumberger JA, et al. Coronary atherosclerosis in unheralded sudden coronary death under age 50: histo-pathologic comparison with ‘healthy’ subjects dying out of hospital. Atherosclerosis. 2001;155:499–508.PubMedCrossRefGoogle Scholar
  150. 150.
    Buffon A, Biasucci LM, Liuzzo G, D’Onofrio G, Crea F, Maseri A. Widespread coronary inflammation in unstable angina. N Engl J Med. 2002;347:5–12.PubMedCrossRefGoogle Scholar
  151. 151.
    Wang TJ, Larson MG, Levy D, Benjamin EJ, Kupka MJ, Manning WJ, et al. C-reactive protein is associated with subclinical epicardial coronary calcification in men and women: the Framingham Heart Study. Circulation. 2002;106:1189–91.PubMedCrossRefGoogle Scholar
  152. 152.
    Silber S. Comparison of spiral and electron beam tomography in the evaluation of coronary calcification in asymptomatic persons. Int J Cardiol. 2002;82:297–8. author reply 299.PubMedCrossRefGoogle Scholar
  153. 153.
    Callister TQ, Cooil B, Raya SP, Lippolis NJ, Russo DJ, Raggi P. Coronary artery disease: improved reproducibility of calcium scoring with an electron-beam CT volumetric method. Radiology. 1998;208:807–14.PubMedGoogle Scholar
  154. 154.
    Haberl R, Becker A, Leber A, Knez A, Becker C, Lang C, et al. Correlation of coronary calcification and angiographically documented stenoses in patients with suspected coronary artery disease: results of 1,764 patients. J Am Coll Cardiol. 2001;37:451–7.PubMedCrossRefGoogle Scholar
  155. 155.
    Marwan M, Ropers D, Pflederer T, Daniel WG, Achenbach S. Clinical characteristics of patients with obstructive coronary lesions in the absence of coronary calcification: an evaluation by coronary CT angiography. Heart. 2009;95:1056–60.PubMedCrossRefGoogle Scholar
  156. 156.
    Arad Y, Spadaro LA, Goodman K, Newstein D, Guerci AD. Prediction of coronary events with electron beam computed tomography. J Am Coll Cardiol. 2000;36:1253–60.PubMedCrossRefGoogle Scholar
  157. 157.
    Hecht HS, Superko HR. Electron beam tomography and National Cholesterol Education Program guidelines in asymptomatic women. J Am Coll Cardiol. 2001;37:1506–11.PubMedCrossRefGoogle Scholar
  158. 158.
    Hadamitzky M, Freissmuth B, Meyer T, Hein F, Kastrati A, Martinoff S, et al. Prognostic value of coronary computed tomographic angiography for prediction of cardiac events in patients with suspected coronary artery disease. JACC Cardiovasc Imaging. 2009;2:404–11.PubMedCrossRefGoogle Scholar
  159. 159.
    Vliegenthart R, Oudkerk M, Song B, van der Kuip DA, Hofman A, Witteman JC. Coronary calcification detected by electron-beam computed tomography and myocardial infarction. The Rotterdam Coronary Calcification Study. Eur Heart J. 2002;23:1596–603.PubMedCrossRefGoogle Scholar
  160. 160.
    Perrone-Filardi P, Achenbach S, Mohlenkamp S, Reiner Z, Sambuceti G, Schuijf JD, et al. Cardiac computed tomography and myocardial perfusion scintigraphy for risk stratification in asymptomatic individuals without known cardiovascular disease: a position statement of the Working Group on Nuclear Cardiology and Cardiac CT of the European Society of Cardiology. Eur Heart J. 2011;32:1986–93. 1993a, 1993b.PubMedCrossRefGoogle Scholar
  161. 161.
    Safar ME, Blacher J, Jankowski P. Arterial stiffness, pulse pressure, and cardiovascular disease—is it possible to break the vicious circle? Atherosclerosis. 2011;218:263–71.PubMedCrossRefGoogle Scholar
  162. 162.
    Mitchell GF, Hwang SJ, Vasan RS, Larson MG, Pencina MJ, Hamburg NM, et al. Arterial stiffness and cardiovascular events: the Framingham Heart Study. Circulation. 2010;121:505–11.PubMedCrossRefGoogle Scholar
  163. 163.
    Fowkes FG, Price JF, Stewart MC, Butcher I, Leng GC, Pell AC, et al. Aspirin for prevention of cardiovascular events in a general population screened for a low ankle brachial index: a randomized controlled trial. JAMA. 2010;303:841–8.PubMedCrossRefGoogle Scholar
  164. 164.
    Tedeschi-Reiner E, Reiner Z, Sonicki Z. Atherosclerosis of retinal arteries in men: role of serum lipoproteins and apoproteins. Croat Med J. 2004;45:333–7.PubMedGoogle Scholar
  165. 165.
    Hansson GK. Inflammation, atherosclerosis, and coronary artery disease. N Engl J Med. 2005;352:1685–95.PubMedCrossRefGoogle Scholar
  166. 166.
    Fox CS, Muntner P, Chen AY, Alexander KP, Roe MT, Cannon CP, et al. Use of evidence-based therapies in short-term outcomes of ST-segment elevation myocardial infarction and non-ST-segment elevation myocardial infarction in patients with chronic kidney disease: a report from the National Cardiovascular Data Acute Coronary Treatment and Intervention Outcomes Network registry. Circulation. 2010;121:357–65.PubMedCrossRefGoogle Scholar
  167. 167.
    Colhoun HM, Betteridge DJ, Durrington PN, Hitman GA, Neil HA, Livingstone SJ, et al. Primary prevention of cardiovascular disease with atorvastatin in type 2 diabetes in the Collaborative Atorvastatin Diabetes Study (CARDS): multicentre randomised placebo-controlled trial. Lancet. 2004;364:685–96.PubMedCrossRefGoogle Scholar
  168. 168.
    Gottlieb DJ, Yenokyan G, Newman AB, O’Connor GT, Punjabi NM, Quan SF, et al. Prospective study of obstructive sleep apnea and incident coronary heart disease and heart failure: the sleep heart health study. Circulation. 2010;122:352–60.PubMedCrossRefGoogle Scholar
  169. 169.
    Cassar A, Morgenthaler TI, Lennon RJ, Rihal CS, Lerman A. Treatment of obstructive sleep apnea is associated with decreased cardiac death after percutaneous coronary intervention. J Am Coll Cardiol. 2007;50:1310–4.PubMedCrossRefGoogle Scholar
  170. 170.
    Gupta BP, Murad MH, Clifton MM, Prokop L, Nehra A, Kopecky SL. The effect of lifestyle modification and cardiovascular risk factor reduction on erectile dysfunction: asystematic review and meta-analysis. Arch Intern Med. 2011;171:1797–803.PubMedCrossRefGoogle Scholar
  171. 171.
    Nichol KL, Nordin J, Mullooly J, Lask R, Fillbrandt K, Iwane M. Influenza vaccination and reduction in hospitalizations for cardiac disease and stroke among the elderly. N Engl J Med. 2003;348:1322–32.PubMedCrossRefGoogle Scholar
  172. 172.
    Van de Werf F, Bax J, Betriu A, Blomstrom-Lundqvist C, Crea F, Falk V, et al. Management of acute myocardial infarction in patients presenting with persistent ST-segment elevation: the Task Force on the Management of ST-Segment Elevation Acute Myocardial Infarction of the European Society of Cardiology. Eur Heart J. 2008;29:2909–45.PubMedCrossRefGoogle Scholar
  173. 173.
    McCullough PA, Jurkovitz CT, Pergola PE, McGill JB, Brown WW, Collins AJ, et al. Independent components of chronic kidney disease as a cardiovascular risk state: results from the Kidney Early Evaluation Program (KEEP). Arch Intern Med. 2007;167:1122–9.PubMedCrossRefGoogle Scholar
  174. 174.
    Baigent C, Landray MJ, Reith C, Emberson J, Wheeler DC, Tomson C, et al. The effects of lowering LDL cholesterol with simvastatin plus ezetimibe in patients with chronic kidney disease (Study of Heart and Renal Protection): a randomised placebo-controlled trial. Lancet. 2011;377:2181–92.PubMedCrossRefGoogle Scholar
  175. 175.
    Young T, Palta M, Dempsey J, Skatrud J, Weber S, Badr S. The occurrence of sleep-disordered breathing among middle-aged adults. N Engl J Med. 1993;328:1230–5.PubMedCrossRefGoogle Scholar
  176. 176.
    Shamsuzzaman AS, Gersh BJ, Somers VK. Obstructive sleep apnea: implications for cardiac and vascular disease. JAMA. 2003;290:1906–14.PubMedCrossRefGoogle Scholar
  177. 177.
    Mooe T, Franklin KA, Holmstrom K, Rabben T, Wiklund U. Sleep-disordered breathing and coronary artery disease: long-term prognosis. Am J Respir Crit Care Med. 2001;164:1910–3.PubMedGoogle Scholar
  178. 178.
    Milleron O, Pilliere R, Foucher A, de Roquefeuil F, Aegerter P, Jondeau G, et al. Benefits of obstructive sleep apnoea treatment in coronary artery disease: a long-term follow-up study. Eur Heart J. 2004;25:728–34.PubMedCrossRefGoogle Scholar
  179. 179.
    Feldman HA, Goldstein I, Hatzichristou DG, Krane RJ, McKinlay JB. Impotence and its medical and psychosocial correlates: results of the Massachusetts Male Aging Study. J Urol. 1994;151:54–61.PubMedGoogle Scholar
  180. 180.
    Benet AE, Melman A. The epidemiology of erectile dysfunction. Urol Clin North Am. 1995;22:699–709.PubMedGoogle Scholar
  181. 181.
    Lue TF. Erectile dysfunction. N Engl J Med. 2000;342:1802–13.PubMedCrossRefGoogle Scholar
  182. 182.
    Feldman HA, Johannes CB, Derby CA, Kleinman KP, Mohr BA, Araujo AB, et al. Erectile dysfunction and coronary risk factors: prospective results from the Massachusetts male aging study. Prev Med. 2000;30:328–38.PubMedCrossRefGoogle Scholar
  183. 183.
    Jackson G. Erectile dysfunction: a marker of silent coronary artery disease. Eur Heart J. 2006;27:2613–4.PubMedCrossRefGoogle Scholar
  184. 184.
    Araujo AB, Hall SA, Ganz P, Chiu GR, Rosen RC, Kupelian V, et al. Does erectile dysfunction contribute to cardiovascular disease risk prediction beyond the Framingham risk score? J Am Coll Cardiol. 2010;55:350–6.PubMedCrossRefGoogle Scholar
  185. 185.
    Gelfand JM, Neimann AL, Shin DB, Wang X, Margolis DJ, Troxel AB. Risk of myocardial infarction in patients with psoriasis. JAMA. 2006;296:1735–41.PubMedCrossRefGoogle Scholar
  186. 186.
    Mehta NN, Azfar RS, Shin DB, Neimann AL, Troxel AB, Gelfand JM. Patients with severe psoriasis are at increased risk of cardiovascular mortality: cohort study using the General Practice Research Database. Eur Heart J. 2010;31:1000–6.PubMedCrossRefGoogle Scholar
  187. 187.
    Westlake SL, Colebatch AN, Baird J, Kiely P, Quinn M, Choy E, et al. The effect of methotrexate on cardiovascular disease in patients with rheumatoid arthritis: a systematic literature review. Rheumatology (Oxford). 2010;49:295–307.CrossRefGoogle Scholar
  188. 188.
    Prodanovich S, Ma F, Taylor JR, Pezon C, Fasihi T, Kirsner RS. Methotrexate reduces incidence of vascular diseases in veterans with psoriasis or rheumatoid arthritis. J Am Acad Dermatol. 2005;52:262–7.PubMedCrossRefGoogle Scholar
  189. 189.
    Recio-Mayoral A, Mason JC, Kaski JC, Rubens MB, Harari OA, Camici PG. Chronic inflammation and coronary microvascular dysfunction in patients without risk factors for coronary artery disease. Eur Heart J. 2009;30:1837–43.PubMedCrossRefGoogle Scholar
  190. 190.
    Tonetti MS, D’Aiuto F, Nibali L, Donald A, Storry C, Parkar M, et al. Treatment of periodontitis and endothelial function. N Engl J Med. 2007;356:911–20.PubMedCrossRefGoogle Scholar
  191. 191.
    Darby S, McGale P, Peto R, Granath F, Hall P, Ekbom A. Mortality from cardiovascular disease more than 10 years after radiotherapy for breast cancer: nationwide cohort study of 90 000 Swedish women. BMJ. 2003;326:256–7.PubMedCrossRefGoogle Scholar
  192. 192.
    Smith GL, Smith BD, Buchholz TA, Giordano SH, Garden AS, Woodward WA, et al. Cerebrovascular disease risk in older head and neck cancer patients after radiotherapy. J Clin Oncol. 2008;26:5119–25.PubMedCrossRefGoogle Scholar
  193. 193.
    Fajardo LF. Is the pathology of radiation injury different in small vs large blood vessels? Cardiovasc Radiat Med. 1999;1:108–10.PubMedCrossRefGoogle Scholar
  194. 194.
    Hunt SA, Haddad F. The changing face of heart transplantation. J Am Coll Cardiol. 2008;52:587–98.PubMedCrossRefGoogle Scholar
  195. 195.
    Dusseldorp E, van Elderen T, Maes S, Meulman J, Kraaij V. A meta-analysis of psychoeduational programs for coronary heart disease patients. Health Psychol. 1999;18:506–19.PubMedCrossRefGoogle Scholar
  196. 196.
    Rubak S, Sandbaek A, Lauritzen T, Christensen B. Motivational interviewing: a systematic review and meta-analysis. Br J Gen Pract. 2005;55:305–12.PubMedGoogle Scholar
  197. 197.
    Clark AM, Hartling L, Vandermeer B, McAlister FA. Meta-analysis: secondary prevention programs for patients with coronary artery disease. Ann Intern Med. 2005;143:659–72.PubMedGoogle Scholar
  198. 198.
    Auer R, Gaume J, Rodondi N, Cornuz J, Ghali WA. Efficacy of in-hospital multidimensional interventions of secondary prevention after acute coronary syndrome: a systematic review and meta-analysis. Circulation. 2008;117:3109–17.PubMedCrossRefGoogle Scholar
  199. 199.
    Linden W, Phillips MJ, Leclerc J. Psychological treatment of cardiac patients: a meta-analysis. Eur Heart J. 2007;28:2972–84.PubMedCrossRefGoogle Scholar
  200. 200.
    Rees K, Bennett P, West R, Davey SG, Ebrahim S. Psychological interventions for coronary heart disease. Cochrane Database Syst Rev. 2004;2:CD002902.PubMedGoogle Scholar
  201. 201.
    Rollnick S, Butler CC, Kinnersley P, Gregory J, Mash B. Motivational interviewing. BMJ. 2010;340:c1900.PubMedCrossRefGoogle Scholar
  202. 202.
    Artinian NT, Fletcher GF, Mozaffarian D, Kris-Etherton P, Van Horn L, Lichtenstein AH, et al. Interventions to promote physical activity and dietary lifestyle changes for cardiovascular risk factor reduction in adults: a scientific statement from the American Heart Association. Circulation. 2010;122:406–41.PubMedCrossRefGoogle Scholar
  203. 203.
    US Preventive Services Task Force. Guide to clinical preventive services. 2nd ed. Washington: US Department of Health & Human Services; 1996.Google Scholar
  204. 204.
    Balady GJ, Williams MA, Ades PA, Bittner V, Comoss P, Foody JM, et al. Core components of cardiac rehabilitation/secondary prevention programs: 2007 update: a scientific statement from the American Heart Association Exercise, Cardiac Rehabilitation, and Prevention Committee, the Council on Clinical Cardiology; the Councils on Cardiovascular Nursing, Epidemiology and Prevention, and Nutrition, Physical Activity, and Metabolism; and the American Association of Cardiovascular and Pulmonary Rehabilitation. Circulation. 2007;115:2675–82.PubMedCrossRefGoogle Scholar
  205. 205.
    Piepoli MF, Corra U, Benzer W, Bjarnason-Wehrens B, Dendale P, Gaita D, et al. Secondary prevention through cardiac rehabilitation: from knowledge to implementation. A position paper from the Cardiac Rehabilitation Section of the European Association of Cardiovascular Prevention and Rehabilitation. Eur J Cardiovasc Prev Rehabil. 2010;17:1–17.PubMedCrossRefGoogle Scholar
  206. 206.
    Burell G, Granlund B. Women’s hearts need special treatment. Int J Behav Med. 2002;9:228–42.PubMedCrossRefGoogle Scholar
  207. 207.
    Doll R, Peto R, Wheatley K, Gray R, Sutherland I. Mortality in relation to smoking: 40 years’ observations on male British doctors. BMJ. 1994;309:901–11.PubMedCrossRefGoogle Scholar
  208. 208.
    Thun MJ, Myers DG, Day-Lally C, Namboodin MM, Calle EE, Flanders WD, et al. Age and the exposure–response relationships between cigarette smoking and premature death in Cancer Prevention Study II. Changes in Cigarette-Related Disease Risks and Their Implications for Prevention and Control. Smoking and Tobacco Control Monograph No. 8. Bethesda: US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Cancer Institute; 1997. p. 383–413.Google Scholar
  209. 209.
    He J, Vupputuri S, Allen K, Prerost MR, Hughes J, Whelton PK. Passive smoking and the risk of coronary heart disease—a meta-analysis of epidemiologic studies. N Engl J Med. 1999;340:920–6.PubMedCrossRefGoogle Scholar
  210. 210.
    Lightwood JM, Glantz SA. Declines in acute myocardial infarction after smoke-free laws and individual risk attributable to secondhand smoke. Circulation. 2009;120:1373–9.PubMedCrossRefGoogle Scholar
  211. 211.
    Center for Disease Control and Prevention. How tobacco smoke causes disease: the biology and behavioural basis for smoking-attributable disease. A report of the surgeon general. 2010. http://www.surgeongeneral.gov/library/tobaccosmoke/index.html
  212. 212.
    Lancaster T, Stead L. Physician advice for smoking cessation. Cochrane Database Syst Rev. 2004;4:CD000165.PubMedGoogle Scholar
  213. 213.
    Stead LF, Perera R, Bullen C, Mant D, Lancaster T. Nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev. 2008;1:CD000146.PubMedGoogle Scholar
  214. 214.
    Edwards R. The problem of tobacco smoking. BMJ. 2004;328:217–9.PubMedCrossRefGoogle Scholar
  215. 215.
    Prescott E, Hippe M, Schnohr P, Hein HO, Vestbo J. Smoking and risk of myocardial infarction in women and men: longitudinal population study. BMJ. 1998;316:1043–7.PubMedCrossRefGoogle Scholar
  216. 216.
    Huisman M, Kunst AE, Mackenbach JP. Inequalities in the prevalence of smoking in the European Union: comparing education and income. Prev Med. 2005;40:756–64.PubMedCrossRefGoogle Scholar
  217. 217.
    Giskes K, Kunst AE, Benach J, Borrell C, Costa G, Dahl E, et al. Trends in smoking behaviour between 1985 and 2000 in nine European countries by education. J Epidemiol Commun Health. 2005;59:395–401.CrossRefGoogle Scholar
  218. 218.
    Mucha L, Stephenson J, Morandi N, Dirani R. Meta-analysis of disease risk associated with smoking, by gender and intensity of smoking. Gend Med. 2006;3:279–91.PubMedCrossRefGoogle Scholar
  219. 219.
    Benowitz NL, Lessov-Schlaggar CN, Swan GE, Jacob 3rd P. Female sex and oral contraceptive use accelerate nicotine metabolism. Clin Pharmacol Ther. 2006;79:480–8.PubMedCrossRefGoogle Scholar
  220. 220.
    Prescott E, Scharling H, Osler M, Schnohr P. Importance of light smoking and inhalation habits on risk of myocardial infarction and all cause mortality. A 22 year follow up of 12 49 men and women in The Copenhagen City Heart Study. J Epidemiol Community Health. 2002;56:702–6.PubMedCrossRefGoogle Scholar
  221. 221.
    WHO Study Group on Tobacco Product Regulation TobReg. Waterpipe tobacco smoking: health effects, research needs and recommended actions by regulators. 2005.Google Scholar
  222. 222.
    Akl EA, Gaddam S, Gunukula SK, Honeine R, Jaoude PA, Irani J. The effects of waterpipe tobacco smoking on health outcomes: a systematic review. Int J Epidemiol. 2010;39:834–57.PubMedCrossRefGoogle Scholar
  223. 223.
    Boffetta P, Straif K. Use of smokeless tobacco and risk of myocardial infarction and stroke: systematic review with meta-analysis. BMJ. 2009;339:b3060.PubMedCrossRefGoogle Scholar
  224. 224.
    Law MR, Morris JK, Wald NJ. Environmental tobacco smoke exposure and ischaemic heart disease: an evaluation of the evidence. BMJ. 1997;315:973–80.PubMedCrossRefGoogle Scholar
  225. 225.
    Raupach T, Schafer K, Konstantinides S, Andreas S. Secondhand smoke as an acute threat for the cardiovascular system: a change in paradigm. Eur Heart J. 2006;27:386–92.PubMedCrossRefGoogle Scholar
  226. 226.
    Steenland K. Risk assessment for heart disease and workplace ETS exposure among nonsmokers. Environ Health Perspect. 1999;107 Suppl 6:859–63.PubMedCrossRefGoogle Scholar
  227. 227.
    Ambrose JA, Barua RS. The pathophysiology of cigarette smoking and cardiovascular disease: an update. J Am Coll Cardiol. 2004;43:1731–7.PubMedCrossRefGoogle Scholar
  228. 228.
    Armani C, Landini Jr L, Leone A. Molecular and biochemical changes of the cardiovascular system due to smoking exposure. Curr Pharm Des. 2009;15:1038–53.PubMedCrossRefGoogle Scholar
  229. 229.
    Rahman MM, Laher I. Structural and functional alteration of blood vessels caused by cigarette smoking: an overview of molecular mechanisms. Curr Vasc Pharmacol. 2007;5:276–92.PubMedCrossRefGoogle Scholar
  230. 230.
    Adams MR, Robinson J, McCredie R, Seale JP, Sorensen KE, Deanfield JE, et al. Smooth muscle dysfunction occurs independently of impaired endothelium-dependent dilation in adults at risk of atherosclerosis. J Am Coll Cardiol. 1998;32:123–7.PubMedCrossRefGoogle Scholar
  231. 231.
    Celermajer DS, Sorensen KE, Georgakopoulos D, Bull C, Thomas O, Robinson J, et al. Cigarette smoking is associated with dose-related and potentially reversible impairment of endothelium-dependent dilation in healthy young adults. Circulation. 1993;88:2149–55.PubMedCrossRefGoogle Scholar
  232. 232.
    Yamaguchi Y, Matsuno S, Kagota S, Haginaka J, Kunitomo M. Oxidants in cigarette smoke extract modify low-density lipoprotein in the plasma and facilitate atherogenesis in the aorta of Watanabe heritable hyperlipidemic rabbits. Atherosclerosis. 2001;156:109–17.PubMedCrossRefGoogle Scholar
  233. 233.
    Taylor BV, Oudit GY, Kalman PG, Liu P. Clinical and pathophysiological effects of active and passive smoking on the cardiovascular system. Can J Cardiol. 1998;14:1129–39.PubMedGoogle Scholar
  234. 234.
    Bermudez EA, Rifai N, Buring JE, Manson JE, Ridker PM. Relation between markers of systemic vascular inflammation and smoking in women. Am J Cardiol. 2002;89:1117–9.PubMedCrossRefGoogle Scholar
  235. 235.
    Benowitz NL, Fitzgerald GA, Wilson M, Zhang Q. Nicotine effects on eicosanoid formation and hemostatic function: comparison of transdermal nicotine and cigarette smoking. J Am Coll Cardiol. 1993;22:1159–67.PubMedCrossRefGoogle Scholar
  236. 236.
    Newby DE, Wright RA, Labinjoh C, Ludlam CA, Fox KA, Boon NA, et al. Endothelial dysfunction impaired endogenous fibrinolysis cigarette smoking: a mechanism for arterial thrombosis myocardial infarction. Circulation. 1999;99:1411–5.PubMedCrossRefGoogle Scholar
  237. 237.
    Newby DE, McLeod AL, Uren NG, Flint L, Ludlam CA, Webb DJ, et al. Impaired coronary tissue plasminogen activator release is associated with coronary atherosclerosis and cigarette smoking: direct link between endothelial dysfunction and atherothrombosis. Circulation. 2001;103:1936–41.PubMedCrossRefGoogle Scholar
  238. 238.
    Simpson AJ, Gray RS, Moore NR, Booth NA. The effects of chronic smoking on the fibrinolytic potential of plasma and platelets. Br J Haematol. 1997;97:208–13.PubMedCrossRefGoogle Scholar
  239. 239.
    Weber C, Erl W, Weber K, Weber PC. Increased adhesiveness of isolated monocytes to endothelium is prevented by vitamin C intake in smokers. Circulation. 1996;93:1488–92.PubMedCrossRefGoogle Scholar
  240. 240.
    Weber C, Erl W, Weber PC. Enhancement of monocyte adhesion to endothelial cells by oxidatively modified low-density lipoprotein is mediated by activation of CD11b. Biochem Biophys Res Commun. 1995;206:621–8.PubMedCrossRefGoogle Scholar
  241. 241.
    Yamaguchi Y, Matsuno S, Kagota S, Haginaka J, Kunitomo M. Peroxynitrite-mediated oxidative modification of low-density lipoprotein by aqueous extracts of cigarette smoke and the preventive effect of fluvastatin. Atherosclerosis. 2004;172:259–65.PubMedCrossRefGoogle Scholar
  242. 242.
    Yamaguchi Y, Haginaka J, Morimoto S, Fujioka Y, Kunitomo M. Facilitated nitration and oxidation of LDL in cigarette smokers. Eur J Clin Invest. 2005;35:186–93.PubMedCrossRefGoogle Scholar
  243. 243.
    Moreno Jr H, Chalon S, Urae A, Tangphao O, Abiose AK, Hoffman BB, et al. Endothelial dysfunction in human hand veins is rapidly reversible after smoking cessation. Am J Physiol. 1998;275:H1040–5.PubMedGoogle Scholar
  244. 244.
    Morita H, Ikeda H, Haramaki N, Eguchi H, Imaizumi T. Only two-week smoking cessation improves platelet aggregability and intraplatelet redox imbalance of long-term smokers. J Am Coll Cardiol. 2005;45:589–94.PubMedCrossRefGoogle Scholar
  245. 245.
    Hanna ST. Nicotine effect on cardiovascular system and ion channels. J Cardiovasc Pharmacol. 2006;47:348–58.PubMedGoogle Scholar
  246. 246.
    Joseph AM, Norman SM, Ferry LH, Prochazka AV, Westman EC, Steele BG, et al. The safety of transdermal nicotine as an aid to smoking cessation in patients with cardiac disease. N Engl J Med. 1996;335:1792–8.PubMedCrossRefGoogle Scholar
  247. 247.
    Joseph AM, Fu SS. Safety issues in pharmacotherapy for smoking in patients with cardiovascular disease. Prog Cardiovasc Dis. 2003;45:429–41.PubMedCrossRefGoogle Scholar
  248. 248.
    International Agency for Research on Cancer. Tobacco control: reversal of risk after quitting smoking. IARC handbooks of cancer prevention, vol. 11. Lyon: IARC; 2007.Google Scholar
  249. 249.
    Critchley J, Capewell S. Smoking cessation for the secondary prevention of coronary heart disease. Cochrane Database Syst Rev. 2004;1:CD003041.PubMedGoogle Scholar
  250. 250.
    Chow CK, Jolly S, Rao-Melacini P, Fox KA, Anand SS, Yusuf S. Association of diet, exercise, and smoking modification with risk of early cardiovascular events after acute coronary syndromes. Circulation. 2010;121:750–8.PubMedCrossRefGoogle Scholar
  251. 251.
    Anthonisen NR, Skeans MA, Wise RA, Manfreda J, Kanner RE, Connett JE. The effects of a smoking cessation intervention on 14.5-year mortality: a randomized clinical trial. Ann Intern Med. 2005;142:233–9.PubMedGoogle Scholar
  252. 252.
    Mohiuddin SM, Mooss AN, Hunter CB, Grollmes TL, Cloutier DA, Hilleman DE. Intensive smoking cessation intervention reduces mortality in high-risk smokers with cardiovascular disease. Chest. 2007;131:446–52.PubMedCrossRefGoogle Scholar
  253. 253.
    National Institute for Health and Clinical Excellence. NICE Public Health Guidance 10. Smoking cessation services in primary care, pharmacies, local authorities and workplaces, particularly for manual working groups, pregnant women and hard to reach communities. 2008. http://www.nice.org.uk/nicemedia/pdf/PH010guidance.pdf
  254. 254.
    Stead LF, Bergson G, Lancaster T. Physician advice for smoking cessation. Cochrane Database Syst Rev. 2008;2:CD000165.PubMedGoogle Scholar
  255. 255.
    Rigotti NA, Munafo MR, Stead LF. Smoking cessation interventions for hospitalized smokers: a systematic review. Arch Intern Med. 2008;168:1950–60.PubMedCrossRefGoogle Scholar
  256. 256.
    Heatherton TF, Kozlowski LT, Frecker RC, Fagerstrom KO. The Fagerstrom Test for Nicotine Dependence: a revision of the Fagerstrom Tolerance Questionnaire. Br J Addict. 1991;86:1119–27.PubMedCrossRefGoogle Scholar
  257. 257.
    Ludvig J, Miner B, Eisenberg MJ. Smoking cessation in patients with coronary artery disease. Am Heart J. 2005;149:565–72.PubMedCrossRefGoogle Scholar
  258. 258.
    Hughes JR, Stead LF, Lancaster T. Antidepressants for smoking cessation. Cochrane Database Syst Rev. 2007;1:CD000031.PubMedGoogle Scholar
  259. 259.
    Cahill K, Stead LF, Lancaster T. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2008;3:CD006103.PubMedGoogle Scholar
  260. 260.
    Rigotti NA, Pipe AL, Benowitz NL, Arteaga C, Garza D, Tonstad S. Efficacy and safety of varenicline for smoking cessation in patients with cardiovascular disease: a randomized trial. Circulation. 2010;121:221–9.PubMedCrossRefGoogle Scholar
  261. 261.
    Cahill K, Stead LF, Lancaster T. Nicotine receptor partial agonists for smoking cessation. Cochrane Database Syst Rev. 2010;12:CD006103.PubMedGoogle Scholar
  262. 262.
    Singh S, Loke YK, Spangler JG, Furberg CD. Risk of serious adverse cardiovascular events associated with varenicline: a systematic review and meta-analysis. CMAJ. 2011;183:1359–66.PubMedCrossRefGoogle Scholar
  263. 263.
    Hawkes N. Varenicline raises risk of heart problems, analysis indicates. BMJ. 2011;343:d4428.CrossRefGoogle Scholar
  264. 264.
    West R, Zatonski W, Cedzynska M, Lewandowska D, Pazik J, Aveyard P, et al. Placebo-controlled trial of cytisine for smoking cessation. N Engl J Med. 2011;365:1193–200.PubMedCrossRefGoogle Scholar
  265. 265.
    Gourlay SG, Stead LF, Benowitz NL. Clonidine for smoking cessation. Cochrane Database Syst Rev. 2004;3:CD000058.PubMedGoogle Scholar
  266. 266.
    Stead LF, Lancaster T. Group behaviour therapy programmes for smoking cessation. Cochrane Database Syst Rev. 2005;2:CD001007.PubMedGoogle Scholar
  267. 267.
    Lancaster T, Stead LF. Individual behavioural counselling for smoking cessation. Cochrane Database Syst Rev. 2005;2:CD001292.PubMedGoogle Scholar
  268. 268.
    Rice VH, Stead LF. Nursing interventions for smoking cessation. Cochrane Database Syst Rev. 2004;1:CD001188.PubMedGoogle Scholar
  269. 269.
    White AR, Rampes H, Campbell JL. Acupuncture and related interventions for smoking cessation. Cochrane Database Syst Rev. 2006;1:CD000009.PubMedGoogle Scholar
  270. 270.
    Astrup A, Dyerberg J, Elwood P, Hermansen K, Hu FB, Jakobsen MU, et al. The role of reducing intakes of saturated fat in the prevention of cardiovascular disease: where does the evidence stand in 2010? Am J Clin Nutr. 2011;93:684–8.PubMedCrossRefGoogle Scholar
  271. 271.
    He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR, et al. Accumulated evidence on fish consumption and coronary heart disease mortality: a meta-analysis of cohort studies. Circulation. 2004;109:2705–11.PubMedCrossRefGoogle Scholar
  272. 272.
    Mozaffarian D, Katan MB, Ascherio A, Stampfer MJ, Willett WC. Trans fatty acids and cardiovascular disease. N Engl J Med. 2006;354:1601–13.PubMedCrossRefGoogle Scholar
  273. 273.
    Dauchet L, Amouyel P, Hercberg S, Dallongeville J. Fruit and vegetable consumption and risk of coronary heart disease: a meta-analysis of cohort studies. J Nutr. 2006;136:2588–93.PubMedGoogle Scholar
  274. 274.
    He FJ, Nowson CA, MacGregor GA. Fruit and vegetable consumption and stroke: meta-analysis of cohort studies. Lancet. 2006;367:320–6.PubMedCrossRefGoogle Scholar
  275. 275.
    Corrao G, Bagnardi V, Zambon A, La Vecchia C. A meta-analysis of alcohol consumption and the risk of 15 diseases. Prev Med. 2004;38:613–9.PubMedCrossRefGoogle Scholar
  276. 276.
    Sofi F, Abbate R, Gensini GF, Casini A. Accruing evidence on benefits of adherence to the Mediterranean diet on health: an updated systematic review and meta-analysis. Am J Clin Nutr. 2010;92:1189–96.PubMedCrossRefGoogle Scholar
  277. 277.
    European Heart Network. Diet, Physical Activity and Cardiovascular Disease Prevention in Europe. 2011.Google Scholar
  278. 278.
    Keys A. Effects of different dietary fats on plasma-lipid levels. Lancet. 1965;1:318–9.PubMedCrossRefGoogle Scholar
  279. 279.
    Siri-Tarino PW, Sun Q, Hu FB, Krauss RM. Meta-analysis of prospective cohort studies evaluating the association of saturated fat with cardiovascular disease. Am J Clin Nutr. 2010;91:535–46.PubMedCrossRefGoogle Scholar
  280. 280.
    Stamler J. Diet–heart: a problematic revisit. Am J Clin Nutr. 2010;91:497–9.PubMedCrossRefGoogle Scholar
  281. 281.
    Mensink RP, Katan MB. Effect of dietary fatty acids on serum lipids and lipoproteins. A meta-analysis of 27 trials. Arterioscler Thromb. 1992;12:911–9.PubMedCrossRefGoogle Scholar
  282. 282.
    He K, Song Y, Daviglus ML, Liu K, Van Horn L, Dyer AR, et al. Fish consumption and incidence of stroke: a meta-analysis of cohort studies. Stroke. 2004;35:1538–42.PubMedCrossRefGoogle Scholar
  283. 283.
    Mozaffarian D, Clarke R. Quantitative effects on cardiovascular risk factors and coronary heart disease risk of replacing partially hydrogenated vegetable oils with other fats and oils. Eur J Clin Nutr. 2009;63 Suppl 2:S22–33.PubMedCrossRefGoogle Scholar
  284. 284.
    He FJ, MacGregor GA. Effect of modest salt reduction on blood pressure: a meta-analysis of randomized trials. Implications for public health. J Hum Hypertens. 2002;16:761–70.PubMedCrossRefGoogle Scholar
  285. 285.
    Sacks FM, Svetkey LP, Vollmer WM, Appel LJ, Bray GA, Harsha D, et al. Effects on blood pressure of reduced dietary sodium and the Dietary Approaches to Stop Hypertension (DASH) diet. DASH–Sodium Collaborative Research Group. N Engl J Med. 2001;344:3–10.PubMedCrossRefGoogle Scholar
  286. 286.
    Bibbins-Domingo K, Chertow GM, Coxson PG, Moran A, Lightwood JM, Pletcher MJ, et al. Projected effect of dietary salt reductions on future cardiovascular disease. N Engl J Med. 2010;362:590–9.PubMedCrossRefGoogle Scholar
  287. 287.
    He FJ, MacGregor GA. Fortnightly review: beneficial effects of potassium. BMJ. 2001;323:497–501.PubMedCrossRefGoogle Scholar
  288. 288.
    Vivekananthan DP, Penn MS, Sapp SK, Hsu A, Topol EJ. Use of antioxidant vitamins for the prevention of cardiovascular disease: meta-analysis of randomised trials. Lancet. 2003;361:2017–23.PubMedCrossRefGoogle Scholar
  289. 289.
    Humphrey LL, Fu R, Rogers K, Freeman M, Helfand M. Homocysteine level and coronary heart disease incidence: a systematic review and meta-analysis. Mayo Clin Proc. 2008;83:1203–12.PubMedCrossRefGoogle Scholar
  290. 290.
    Marti-Carvajal AJ, Sola I, Lathyris D, Salanti G. Homocysteine lowering interventions for preventing cardiovascular events. Cochrane Database Syst Rev. 2009;4:CD006612.PubMedGoogle Scholar
  291. 291.
    Armitage JM, Bowman L, Clarke RJ, Wallendszus K, Bulbulia R, Rahimi K, et al. Effects of homocysteine-lowering with folic acid plus vitamin B12 vs placebo on mortality and major morbidity in myocardial infarction survivors: a randomized trial. JAMA. 2010;303:2486–94.PubMedCrossRefGoogle Scholar
  292. 292.
    Galan P, Kesse-Guyot E, Czernichow S, Briancon S, Blacher J, Hercberg S. Effects of B vitamins and omega 3 fatty acids on cardiovascular diseases: a randomised placebo controlled trial. BMJ. 2010;341:c6273.PubMedCrossRefGoogle Scholar
  293. 293.
    B vitamins in patients with recent transient ischaemic attack or stroke in the VITAmins TO Prevent Stroke (VITATOPS) trial: a randomised, double-blind, parallel, placebocontrolled trial. Lancet Neurol. 2010;9:855–65.Google Scholar
  294. 294.
    Abuannadi M, O’Keefe J. Give me sunshine: vitamin D cardiovascular health. Prim Care Cardiovasc J. 2011;4:59–62.Google Scholar
  295. 295.
    Weickert MO, Pfeiffer AF. Metabolic effects of dietary fiber consumption and prevention of diabetes. J Nutr. 2008;138:439–42.PubMedGoogle Scholar
  296. 296.
    Food and Nutrition Board. Dietary reference intakes for energy, carbohydrates, fiber, fat, fatty acids, cholesterol, protein and amino acids. Washington: National Academies Press; 2002.Google Scholar
  297. 297.
    Appel LJ, Moore TJ, Obarzanek E, Vollmer WM, Svetkey LP, Sacks FM, et al. A clinical trial of the effects of dietary patterns on blood pressure. DASH Collaborative Research Group. N Engl J Med. 1997;336:1117–24.PubMedCrossRefGoogle Scholar
  298. 298.
    Mozaffarian D, Rimm EB. Fish intake, contaminants, and human health: evaluating the risks and the benefits. JAMA. 2006;296:1885–99.PubMedCrossRefGoogle Scholar
  299. 299.
    Opie LH, Lecour S. The red wine hypothesis: from concepts to protective signalling molecules. Eur Heart J. 2007;28:1683–93.PubMedCrossRefGoogle Scholar
  300. 300.
    Malik VS, Popkin BM, Bray GA, Despres JP, Hu FB. Sugar-sweetened beverages, obesity, type 2 diabetes mellitus, and cardiovascular disease risk. Circulation. 2010;121:1356–64.PubMedCrossRefGoogle Scholar
  301. 301.
    Fung TT, Malik V, Rexrode KM, Manson JE, Willett WC, Hu FB. Sweetened beverage consumption and risk of coronary heart disease in women. Am J Clin Nutr. 2009;89:1037–42.PubMedCrossRefGoogle Scholar
  302. 302.
    Law M. Plant sterol and stanol margarines and health. BMJ. 2000;320:861–4.PubMedCrossRefGoogle Scholar
  303. 303.
    Schonfeld G. Plant sterols in atherosclerosis prevention. Am J Clin Nutr. 2010;92:3–4.PubMedCrossRefGoogle Scholar
  304. 304.
    Verschuren WM, Jacobs DR, Bloemberg BP, Kromhout D, Menotti A, Aravanis C, et al. Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study. JAMA. 1995;274:131–6.PubMedCrossRefGoogle Scholar
  305. 305.
    Talbot LA, Morrell CH, Fleg JL, Metter EJ. Changes in leisure time physical activity and risk of all-cause mortality in men and women: the Baltimore Longitudinal Study of Aging. Prev Med. 2007;45:169–76.PubMedCrossRefGoogle Scholar
  306. 306.
    Nocon M, Hiemann T, Muller-Riemenschneider F, Thalau F, Roll S, Willich SN. Association of physical activity with all-cause and cardiovascular mortality: a systematic review and meta-analysis. Eur J Cardiovasc Prev Rehabil. 2008;15:239–46.PubMedCrossRefGoogle Scholar
  307. 307.
    Lollgen H, Bockenhoff A, Knapp G. Physical activity and all-cause mortality: an updated meta-analysis with different intensity categories. Int J Sports Med. 2009;30:213–24.PubMedCrossRefGoogle Scholar
  308. 308.
    US Department of Health and Human Services. Physical Activity Guidelines Advisory Committee Report. 2008. http://www.health.gov/PAguidelines/Report/pdf/CommitteeReport.pdf
  309. 309.
    Richardson CR, Kriska AM, Lantz PM, Hayward RA. Physical activity and mortality across cardiovascular disease risk groups. Med Sci Sports Exerc. 2004;36:1923–9.PubMedCrossRefGoogle Scholar
  310. 310.
    Taylor RS, Brown A, Ebrahim S, Jolliffe J, Noorani H, Rees K, et al. Exercise-based rehabilitation for patients with coronary heart disease: systematic review and meta-analysis of randomized controlled trials. Am J Med. 2004;116:682–92.PubMedCrossRefGoogle Scholar
  311. 311.
    Piepoli MF, Davos C, Francis DP, Coats AJ. Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ. 2004;328:189.PubMedCrossRefGoogle Scholar
  312. 312.
    Warren TY, Barry V, Hooker SP, Sui X, Church TS, Blair SN. Sedentary behaviors increase risk of cardiovascular disease mortality in men. Med Sci Sports Exerc. 2010;42:879–85.PubMedCrossRefGoogle Scholar
  313. 313.
    US Department of Health and Human Services. 2008 Physical Activity Guidelines for Americans. 2008. http://www.health.gov/paguidelines/pdf/paguide.pdf
  314. 314.
    Margetts BM, Rogers E, Widhal K, Remaut de Winter AM, Zunft HJ. Relationship between attitudes to health, body weight and physical activity and level of physical activity in a nationally representative sample in the European Union. Public Health Nutr. 1999;2:97–103.PubMedGoogle Scholar
  315. 315.
    Afonso C, Graca P, Kearney JM, Gibney MJ, de Almeida MD. Physical activity in European seniors: attitudes, beliefs and levels. J Nutr Health Aging. 2001;5:226–9.PubMedGoogle Scholar
  316. 316.
    Fry J, Finley W. The prevalence and costs of obesity in the EU. Proc Nutr Soc. 2005;64:359–62.PubMedCrossRefGoogle Scholar
  317. 317.
    Cattaneo A, Monasta L, Stamatakis E, Lioret S, Castetbon K, Frenken F, et al. Overweight and obesity in infants and pre-school children in the European Union: a review of existing data. Obes Rev. 2010;11:389–98.PubMedCrossRefGoogle Scholar
  318. 318.
    Vanhees L, McGee HM, Dugmore LD, Schepers D, van Daele P. A representative study of cardiac rehabilitation activities in European Union Member States: the Carinex survey. J Cardiopulm Rehabil. 2002;22:264–72.PubMedCrossRefGoogle Scholar
  319. 319.
    Helis E, Augustincic L, Steiner S, Chen L, Turton P, Fodor JG. Time trends in cardiovascular and all-cause mortality in the ‘old’ and ‘new’ European Union countries. Eur J Cardiovasc Prev Rehabil. 2011.Google Scholar
  320. 320.
    Schnohr P, Scharling H, Jensen JS. Intensity versus duration of walking, impact on mortality: the Copenhagen City Heart Study. Eur J Cardiovasc Prev Rehabil. 2007;14:72–8.PubMedCrossRefGoogle Scholar
  321. 321.
    Durstine JL, Painter P, Franklin BA, Morgan D, Pitetti KH, Roberts SO. Physical activity for the chronically ill and disabled. Sports Med. 2000;30:207–19.PubMedCrossRefGoogle Scholar
  322. 322.
    Fletcher GF, Balady GJ, Amsterdam EA, Chaitman B, Eckel R, Fleg J, et al. Exercise standards for testing and training: a statement for healthcare professionals from the American Heart Association. Circulation. 2001;104:1694–740.PubMedCrossRefGoogle Scholar
  323. 323.
    Linke A, Erbs S, Hambrecht R. Effects of exercise training upon endothelial function in patients with cardiovascular disease. Front Biosci. 2008;13:424–32.PubMedCrossRefGoogle Scholar
  324. 324.
    Di Francescomarino S, Sciartilli A, Di Valerio V, Di Baldassarre A, Gallina S. The effect of physical exercise on endothelial function. Sports Med. 2009;39:797–812.PubMedCrossRefGoogle Scholar
  325. 325.
    Lippi G, Maffulli N. Biological influence of physical exercise on hemostasis. Semin Thromb Hemost. 2009;35:269–76.PubMedCrossRefGoogle Scholar
  326. 326.
    Billman GE. Cardiac autonomic neural remodeling and susceptibility to sudden cardiac death: effect of endurance exercise training. Am J Physiol Heart Circ Physiol. 2009;297:H1171–93.PubMedCrossRefGoogle Scholar
  327. 327.
    Kavazis AN. Exercise preconditioning of the myocardium. Sports Med. 2009;39:923–35.PubMedCrossRefGoogle Scholar
  328. 328.
    Williams PT. Physical fitness and activity as separate heart disease risk factors: a meta-analysis. Med Sci Sports Exerc. 2001;33:754–61.PubMedGoogle Scholar
  329. 329.
    Tipton CM. ACSM’s advanced exercise physiology. Baltimore: Lippincott Williams & Wilkins; 2006.Google Scholar
  330. 330.
    Franklin BA. Cardiovascular events associated with exercise. The risk–protection paradox. J Cardiopulm Rehabil. 2005;25:189–95. quiz 196–187.PubMedCrossRefGoogle Scholar
  331. 331.
    Thompson PD, Franklin BA, Balady GJ, Blair SN, Corrado D, Estes 3rd NA, et al. Exercise and acute cardiovascular events placing the risks into perspective: a scientific statement from the American Heart Association Council on Nutrition, Physical Activity, and Metabolism and the Council on Clinical Cardiology. Circulation. 2007;115:2358–68.PubMedCrossRefGoogle Scholar
  332. 332.
    Borjesson M, Urhausen A, Kouidi E, Dugmore D, Sharma S, Halle M, et al. Cardiovascular evaluation of middle-aged/senior individuals engaged in leisure-time sport activities: position stand from the sections of exercise physiology and sports cardiology of the European Association of Cardiovascular Prevention and Rehabilitation. Eur J Cardiovasc Prev Rehabil. 2011;18:446–58.PubMedCrossRefGoogle Scholar
  333. 333.
    Heran BS, Chen JM, Ebrahim S, Moxham T, Oldridge N, Rees K, et al. Exercise-based cardiac rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 2011;7:CD001800.PubMedGoogle Scholar
  334. 334.
    Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, et al. Prediction of long-term prognosis in 12 169 men referred for cardiac rehabilitation. Circulation. 2002;106:666–71.PubMedCrossRefGoogle Scholar
  335. 335.
    Kavanagh T, Mertens DJ, Hamm LF, Beyene J, Kennedy J, Corey P, et al. Peak oxygen intake and cardiac mortality in women referred for cardiac rehabilitation. J Am Coll Cardiol. 2003;42:2139–43.PubMedCrossRefGoogle Scholar
  336. 336.
    Hambrecht R, Walther C, Mobius-Winkler S, Gielen S, Linke A, Conradi K, et al. Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trial. Circulation. 2004;109:1371–8.PubMedCrossRefGoogle Scholar
  337. 337.
    O’Connor CM, Whellan DJ, Lee KL, Keteyian SJ, Cooper LS, Ellis SJ, et al. Efficacy and safety of exercise training in patients with chronic heart failure: HF-ACTION randomized controlled trial. JAMA. 2009;301:1439–50.PubMedCrossRefGoogle Scholar
  338. 338.
    American Association of Cardiovascular & Pulmonary Rehabilitation. Guidelines for cardiac rehabilitation and secondary prevention programs. Champaign: Human Kinetics; 2004.Google Scholar
  339. 339.
    American College of Sports Medicine. ACSM’s guidelines for exercise testing and prescription. 8th ed. Baltimore: Lippincott, Williams and Wilkins; 2009.Google Scholar
  340. 340.
    Franklin BA, Bonzheim K, Gordon S, Timmis GC. Safety of medically supervised outpatient cardiac rehabilitation exercise therapy: a 16-year follow-up. Chest. 1998;114:902–6.PubMedCrossRefGoogle Scholar
  341. 341.
    Scheinowitz M, Harpaz D. Safety of cardiac rehabilitation in a medically supervised, community-based program. Cardiology. 2005;103:113–7.PubMedCrossRefGoogle Scholar
  342. 342.
    Rees K, Taylor RS, Singh S, Coats AJ, Ebrahim S. Exercise based rehabilitation for heart failure. Cochrane Database Syst Rev. 2004;3:CD003331.PubMedGoogle Scholar
  343. 343.
    Whalley B, Rees K, Davies P, Bennett P, Ebrahim S, Liu Z, et al. Psychological interventions for coronary heart disease. Cochrane Database Syst Rev. 2011;8:CD002902.PubMedGoogle Scholar
  344. 344.
    Schneiderman N, Saab PG, Catellier DJ, Powell LH, DeBusk RF, Williams RB, et al. Psychosocial treatment within sex by ethnicity subgroups in the Enhancing Recovery in Coronary Heart Disease clinical trial. Psychosom Med. 2004;66:475–83.PubMedCrossRefGoogle Scholar
  345. 345.
    Taylor CB, Youngblood ME, Catellier D, Veith RC, Carney RM, Burg MM, et al. Effects of antidepressant medication on morbidity and mortality in depressed patients after myocardial infarction. Arch Gen Psychiatry. 2005;62:792–8.PubMedCrossRefGoogle Scholar
  346. 346.
    Carney RM, Blumenthal JA, Freedland KE, Youngblood M, Veith RC, Burg MM, et al. Depression and late mortality after myocardial infarction in the Enhancing Recovery in Coronary Heart Disease (ENRICHD) study. Psychosom Med. 2004;66:466–74.PubMedCrossRefGoogle Scholar
  347. 347.
    Sauer WH, Berlin JA, Kimmel SE. Effect of antidepressants and their relative affinity for the serotonin transporter on the risk of myocardial infarction. Circulation. 2003;108:32–6.PubMedCrossRefGoogle Scholar
  348. 348.
    Orth-Gomer K, Schneiderman N, Wang HX, Walldin C, Blom M, Jernberg T. Stress reduction prolongs life in women with coronary disease: the Stockholm Women’s Intervention Trial for Coronary Heart Disease (SWITCHD). Circ Cardiovasc Qual Outcomes. 2009;2:25–32.PubMedCrossRefGoogle Scholar
  349. 349.
    Cossette S, Frasure-Smith N, Lesperance F. Clinical implications of a reduction in psychological distress on cardiac prognosis in patients participating in a psychosocial intervention program. Psychosom Med. 2001;63:257–66.PubMedGoogle Scholar
  350. 350.
    Bjarnason-Wehrens B, Grande G, Loewel H, Voller H, Mittag O. Gender-specific issues in cardiac rehabilitation: do women with ischaemic heart disease need specially tailored programmes? Eur J Cardiovasc Prev Rehabil. 2007;14:163–71.PubMedCrossRefGoogle Scholar
  351. 351.
    Berkman LF, Blumenthal J, Burg M, Carney RM, Catellier D, Cowan MJ, et al. Effects of treating depression and low perceived social support on clinical events after myocardial infarction: the Enhancing Recovery in Coronary Heart Disease Patients (ENRICHD) Randomized Trial. JAMA. 2003;289:3106–16.PubMedCrossRefGoogle Scholar
  352. 352.
    Lesperance F, Frasure-Smith N, Koszycki D, Laliberte MA, van Zyl LT, Baker B, et al. Effects of citalopram and interpersonal psychotherapy on depression in patients with coronary artery disease: the Canadian Cardiac Randomized Evaluation of Antidepressant and Psychotherapy Efficacy (CREATE) trial. JAMA. 2007;297:367–79.PubMedCrossRefGoogle Scholar
  353. 353.
    Freedland KE, Skala JA, Carney RM, Rubin EH, Lustman PJ, Davila-Roman VG, et al. Treatment of depression after coronary artery bypass surgery: arandomized controlled trial. Arch Gen Psychiatry. 2009;66:387–96.PubMedCrossRefGoogle Scholar
  354. 354.
    Glassman AH, O’Connor CM, Califf RM, Swedberg K, Schwartz P, Bigger Jr JT, et al. Sertraline treatment of major depression in patients with acute MI or unstable angina. JAMA. 2002;288:701–9.PubMedCrossRefGoogle Scholar
  355. 355.
    van Melle JP, de Jonge P, Honig A, Schene AH, Kuyper AM, Crijns HJ, et al. Effects of antidepressant treatment following myocardial infarction. Br J Psychiatry. 2007;190:460–6.PubMedCrossRefGoogle Scholar
  356. 356.
    Dowlati Y, Herrmann N, Swardfager WL, Reim EK, Lanctot KL. Efficacy and tolerability of antidepressants for treatment of depression in coronary artery disease: a meta-analysis. Can J Psychiatry. 2010;55:91–9.PubMedGoogle Scholar
  357. 357.
    Lie I, Arnesen H, Sandvik L, Hamilton G, Bunch EH. Effects of a home-based intervention program on anxiety and depression 6 months after coronary artery bypass grafting: a randomized controlled trial. J Psychosom Res. 2007;62:411–8.PubMedCrossRefGoogle Scholar
  358. 358.
    Gulliksson M, Burell G, Vessby B, Lundin L, Toss H, Svardsudd K. Randomized controlled trial of cognitive behavioral therapy vs standard treatment to prevent recurrent cardiovascular events in patients with coronary heart disease: Secondary Prevention in Uppsala Primary Health Care project (SUPRIM). Arch Intern Med. 2011;171:134–40.PubMedCrossRefGoogle Scholar
  359. 359.
    Gidron Y, Davidson K, Bata I. The short-term effects of a hostility-reduction intervention on male coronary heart disease patients. Health Psychol. 1999;18:416–20.PubMedCrossRefGoogle Scholar
  360. 360.
    Bishop GD, Kaur D, Tan VL, Chua YL, Liew SM, Mak KH. Effects of a psychosocial skills training workshop on psychophysiological and psychosocial risk in patients undergoing coronary artery bypass grafting. Am Heart J. 2005;150:602–9.PubMedCrossRefGoogle Scholar
  361. 361.
    Claesson M, Birgander LS, Lindahl B, Nasic S, Astrom M, Asplund K, et al. Women’s hearts—stress management for women with ischemic heart disease: explanatory analyses of a randomized controlled trial. J Cardiopulm Rehabil. 2005;25:93–102.PubMedCrossRefGoogle Scholar
  362. 362.
    Theorell T, Emdad R, Arnetz B, Weingarten AM. Employee effects of an educational program for managers at an insurance company. Psychosom Med. 2001;63:724–33.PubMedGoogle Scholar
  363. 363.
    Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J, et al. Body-mass index and cause-specific mortality in 900 000 adults: collaborative analyses of 57 prospective studies. Lancet. 2009;373:1083–96.PubMedCrossRefGoogle Scholar
  364. 364.
    Berrington de Gonzalez A, Hartge P, Cerhan JR, Flint AJ, Hannan L, MacInnis RJ, et al. Body-mass index and mortality among 1.46 million white adults. N Engl J Med. 2010;363:2211–9.PubMedCrossRefGoogle Scholar
  365. 365.
    Zheng W, McLerran DF, Rolland B, Zhang X, Inoue M, Matsuo K, et al. Association between body-mass index and risk of death in more than 1 million Asians. N Engl J Med. 2011;364:719–29.PubMedCrossRefGoogle Scholar
  366. 366.
    Romero-Corral A, Montori VM, Somers VK, Korinek J, Thomas RJ, Allison TG, et al. Association of bodyweight with total mortality and with cardiovascular events in coronary artery disease: a systematic review of cohort studies. Lancet. 2006;368:666–78.PubMedCrossRefGoogle Scholar
  367. 367.
    Oreopoulos A, Padwal R, Norris CM, Mullen JC, Pretorius V, Kalantar-Zadeh K. Effect of obesity on short- and long-term mortality postcoronary revascularization: a meta-analysis. Obesity (Silver Spring). 2008;16:442–50.CrossRefGoogle Scholar
  368. 368.
    Hastie CE, Padmanabhan S, Slack R, Pell AC, Oldroyd KG, Flapan AD, et al. Obesity paradox in a cohort of 4880 consecutive patients undergoing percutaneous coronary intervention. Eur Heart J. 2010;31:222–6.PubMedCrossRefGoogle Scholar
  369. 369.
    Lavie CJ, Milani RV, Ventura HO. Obesity and cardiovascular disease: risk factor, paradox, and impact of weight loss. J Am Coll Cardiol. 2009;53:1925–32.PubMedCrossRefGoogle Scholar
  370. 370.
    Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, et al. Obesity, cardiovascular disease: pathophysiology, evaluation, effect of weight loss: an update of the 1997 American Heart Association Scientific Statement on Obesity and Heart Disease from the Obesity Committee of the Council on Nutrition, Physical Activity, and Metabolism. Circulation. 2006;113:898–918.PubMedCrossRefGoogle Scholar
  371. 371.
    Stewart ST, Cutler DM, Rosen AB. Forecasting the effects of obesity and smoking on U.S. life expectancy. N Engl J Med. 2009;361:2252–60.PubMedCrossRefGoogle Scholar
  372. 372.
    Pischon T, Boeing H, Hoffmann K, Bergmann M, Schulze MB, Overvad K, et al. General and abdominal adiposity and risk of death in Europe. N Engl J Med. 2008;359:2105–20.PubMedCrossRefGoogle Scholar
  373. 373.
    Haslam DW, James WP. Obesity. Lancet. 2005;366:1197–209.PubMedCrossRefGoogle Scholar
  374. 374.
    World Health Organization. Obesity: preventing and managing the global epidemic. Report of a WHO Consultation. World Health Organization Technical Report Series, Report No. 894. 1998.Google Scholar
  375. 375.
    Li C, Engstrom G, Hedblad B, Calling S, Berglund G, Janzon L. Sex differences in the relationships between BMI, WHR and incidence of cardiovascular disease: a populationbased cohort study. Int J Obes (Lond). 2006;30:1775–81.CrossRefGoogle Scholar
  376. 376.
    Freiberg MS, Pencina MJ, D’Agostino RB, Lanier K, Wilson PW, Vasan RS. BMI vs. waist circumference for identifying vascular risk. Obesity (Silver Spring). 2008;16:463–9.CrossRefGoogle Scholar
  377. 377.
    Yusuf S, Hawken S, Ounpuu S, Bautista L, Franzosi MG, Commerford P, et al. Obesity and the risk of myocardial infarction in 27,000 participants from 52 countries: a case–control study. Lancet. 2005;366:1640–9.PubMedCrossRefGoogle Scholar
  378. 378.
    Vazquez G, Duval S, Jacobs Jr DR, Silventoinen K. Comparison of body mass index, waist circumference, and waist/hip ratio in predicting incident diabetes: a meta-analysis. Epidemiol Rev. 2007;29:115–28.PubMedCrossRefGoogle Scholar
  379. 379.
    Taylor AE, Ebrahim S, Ben-Shlomo Y, Martin RM, Whincup PH, Yarnell JW, et al. Comparison of the associations of body mass index and measures of central adiposity and fat mass with coronary heart disease, diabetes, and all-cause mortality: a study using data from 4 UK cohorts. Am J Clin Nutr. 2010;91:547–56.PubMedCrossRefGoogle Scholar
  380. 380.
    Wannamethee SG, Shaper AG, Lennon L, Whincup PH. Decreased muscle mass and increased central adiposity are independently related to mortality in older men. Am J Clin Nutr. 2007;86:1339–46.PubMedGoogle Scholar
  381. 381.
    Sebo P, Beer-Borst S, Haller DM, Bovier PA. Reliability of doctors’ anthropometric measurements to detect obesity. Prev Med. 2008;47:389–93.PubMedCrossRefGoogle Scholar
  382. 382.
    Nadas J, Putz Z, Kolev G, Nagy S, Jermendy G. Intraobserver and interobserver variability of measuring waist circumference. Med Sci Monit. 2008;14:CR15–8.PubMedGoogle Scholar
  383. 383.
    Nordhamn K, Sodergren E, Olsson E, Karlstrom B, Vessby B, Berglund L. Reliability of anthropometric measurements in overweight and lean subjects: consequences for correlations between anthropometric and other variables. Int J Obes Relat Metab Disord. 2000;24:652–7.PubMedCrossRefGoogle Scholar
  384. 384.
    Kramer MS, Martin RM, Sterne JA, Shapiro S, Dahhou M, Platt RW. The double jeopardy of clustered measurement and cluster randomisation. BMJ. 2009;339:b2900.PubMedCrossRefGoogle Scholar
  385. 385.
    Ashwell M, Chinn S, Stalley S, Garrow JS. Female fat distribution—a simple classification based on two circumference measurements. Int J Obes. 1982;6:143–52.PubMedGoogle Scholar
  386. 386.
    Lohman TG, Roche AF, Martorell R, editors. Anthoropometric standardization reference manual. Champaign: Human Kinetics Books; 1998.Google Scholar
  387. 387.
    Poirier P, Alpert MA, Fleisher LA, Thompson PD, Sugerman HJ, Burke LE, et al. Cardiovascular evaluation and management of severely obese patients undergoing surgery: a science advisory from the American Heart Association. Circulation. 2009;120:86–95.PubMedCrossRefGoogle Scholar
  388. 388.
    Drew BS, Dixon AF, Dixon JB. Obesity management: update on orlistat. Vasc Health Risk Manag. 2007;3:817–21.PubMedGoogle Scholar
  389. 389.
    Poirier P, Cornier MA, Mazzone T, Stiles S, Cummings S, Klein S, et al. Bariatric surgery and cardiovascular risk factors: a scientific statement from the American Heart Association. Circulation. 2011;123:1683–701.PubMedCrossRefGoogle Scholar
  390. 390.
    Neter JE, Stam BE, Kok FJ, Grobbee DE, Geleijnse JM. Influence of weight reduction on blood pressure: a meta-analysis of randomized controlled trials. Hypertension. 2003;42:878–84.PubMedCrossRefGoogle Scholar
  391. 391.
    Cornelissen VA, Fagard RH, Coeckelberghs E, Vanhees L. Impact of resistance training on blood pressure and other cardiovascular risk factors: a meta-analysis of randomized, controlled trials. Hypertension. 2011;58:950–8.PubMedCrossRefGoogle Scholar
  392. 392.
    McFadden CB, Brensinger CM, Berlin JA, Townsend RR. Systematic review of the effect of daily alcohol intake on blood pressure. Am J Hypertens. 2005;18:276–86.PubMedCrossRefGoogle Scholar
  393. 393.
    He FJ, MacGregor GA. Salt reduction lowers cardiovascular risk: meta-analysis of outcome trials. Lancet. 2011;378:380–2.PubMedCrossRefGoogle Scholar
  394. 394.
    Law MR, Morris JK, Wald NJ. Use of blood pressure lowering drugs in the prevention of cardiovascular disease: meta-analysis of 147 randomised trials in the context of expectations from prospective epidemiological studies. BMJ. 2009;338:b1665.PubMedCrossRefGoogle Scholar
  395. 395.
    Poulter NR, Wedel H, Dahlof B, Sever PS, Beevers DG, Caulfield M, et al. Role of blood pressure other variables in the differential cardiovascular event rates noted in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA). Lancet. 2005;366:907–13.PubMedCrossRefGoogle Scholar
  396. 396.
    Elliott WJ, Meyer PM. Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. Lancet. 2007;369:201–7.PubMedCrossRefGoogle Scholar
  397. 397.
    Patel A, MacMahon S, Chalmers J, Neal B, Woodward M, Billot L, et al. Effects of a fixed combination of perindopril and indapamide on macrovascular and microvascular outcomes in patients with type 2 diabetes mellitus (the ADVANCE trial): a randomised controlled trial. Lancet. 2007;370:829–40.PubMedCrossRefGoogle Scholar
  398. 398.
    Turnbull F, Neal B, Algert C, Chalmers J, Chapman N, Cutler J, et al. Effects of different blood pressure-lowering regimens on major cardiovascular events in individuals with and without diabetes mellitus: results of prospectively designed overviews of randomized trials. Arch Intern Med. 2005;165:1410–9.PubMedCrossRefGoogle Scholar
  399. 399.
    Viberti G, Wheeldon NM. Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect. Circulation. 2002;106:672–8.PubMedCrossRefGoogle Scholar
  400. 400.
    Sehestedt T, Jeppesen J, Hansen TW, Wachtell K, Ibsen H, Torp-Pedersen C, et al. Risk prediction is improved by adding markers of subclinical organ damage to SCORE. Eur Heart J. 2010;31:883–91.PubMedCrossRefGoogle Scholar
  401. 401.
    Mancia G, De Backer G, Dominiczak A, Cifkova R, Fagard R, Germano G, et al. 2007 ESH-ESC Practice Guidelines for the Management of Arterial Hypertension: ESH-ESC Task Force on the Management of Arterial Hypertension. J Hypertens. 2007;25:1751–62.PubMedCrossRefGoogle Scholar
  402. 402.
    Zanchetti A, Grassi G, Mancia G. When should antihypertensive drug treatment be initiated and to what levels should systolic blood pressure be lowered? A critical reappraisal. J Hypertens. 2009;27:923–34.PubMedCrossRefGoogle Scholar
  403. 403.
    Liu L, Zhang Y, Liu G, Li W, Zhang X, Zanchetti A. The Felodipine Event Reduction (FEVER) Study: a randomized long-term placebo-controlled trial in Chinese hypertensive patients. J Hypertens. 2005;23:2157–72.PubMedCrossRefGoogle Scholar
  404. 404.
    Weber MA, Julius S, Kjeldsen SE, Brunner HR, Ekman S, Hansson L, et al. Blood pressure dependent and independent effects of antihypertensive treatment on clinical events in the VALUE Trial. Lancet. 2004;363:2049–51.PubMedCrossRefGoogle Scholar
  405. 405.
    Blackburn DF, Lamb DA, Eurich DT, Johnson JA, Wilson TW, Dobson RT, et al. Atenolol as initial antihypertensive therapy: an observational study comparing first-line agents. J Hypertens. 2007;25:1499–505.PubMedCrossRefGoogle Scholar
  406. 406.
    Zanchetti A, Hansson L, Dahlof B, Julius S, Menard J, Warnold I, et al. Benefit and harm of low-dose aspirin in well-treated hypertensives at different baseline cardiovascular risk. J Hypertens. 2002;20:2301–7.PubMedCrossRefGoogle Scholar
  407. 407.
    Ruilope LM, Salvetti A, Jamerson K, Hansson L, Warnold I, Wedel H, et al. Renal function and intensive lowering of blood pressure in hypertensive participants of the hypertension optimal treatment (HOT) study. J Am Soc Nephrol. 2001;12:218–25.PubMedGoogle Scholar
  408. 408.
    Jardine MJ, Ninomiya T, Perkovic V, Cass A, Turnbull F, Gallagher MP, et al. Aspirin is beneficial in hypertensive patients with chronic kidney disease: a post-hoc subgroup analysis of a randomized controlled trial. J Am Coll Cardiol. 2010;56:956–65.PubMedCrossRefGoogle Scholar
  409. 409.
    MacMahon S, Peto R, Cutler J, Collins R, Sorlie P, Neaton J, et al. Blood pressure, stroke, and coronary heart disease. Part 1, Prolonged differences in blood pressure: prospective observational studies corrected for the regression dilution bias. Lancet. 1990;335:765–74.PubMedCrossRefGoogle Scholar
  410. 410.
    Wattigney WA, Mensah GA, Croft JB. Increasing trends in hospitalization for atrial fibrillation in the United States, 1985 through 1999: implications for primary prevention. Circulation. 2003;108:711–6.PubMedCrossRefGoogle Scholar
  411. 411.
    Skoog I, Lernfelt B, Landahl S, Palmertz B, Andreasson LA, Nilsson L, et al. 15-year longitudinal study of blood pressure and dementia. Lancet. 1996;347:1141–5.PubMedCrossRefGoogle Scholar
  412. 412.
    Lewington S, Clarke R, Qizilbash N, Peto R, Collins R. Age-specific relevance of usual blood pressure to vascular mortality: a meta-analysis of individual data for one million adults in 61 prospective studies. Lancet. 2002;360:1903–13.PubMedCrossRefGoogle Scholar
  413. 413.
    Franklin SS, Larson MG, Khan SA, Wong ND, Leip EP, Kannel WB, et al. Does the relation of blood pressure to coronary heart disease risk change with aging? The Framingham Heart Study. Circulation. 2001;103:1245–9.PubMedCrossRefGoogle Scholar
  414. 414.
    Benetos A, Zureik M, Morcet J, Thomas F, Bean K, Safar M, et al. A decrease in diastolic blood pressure combined with an increase in systolic blood pressure is associated with a higher cardiovascular mortality in men. J Am Coll Cardiol. 2000;35:673–80.PubMedCrossRefGoogle Scholar
  415. 415.
    O’Brien E, Asmar R, Beilin L, Imai Y, Mallion JM, Mancia G, et al. European Society of Hypertension recommendations for conventional, ambulatory and home blood pressure measurement. J Hypertens. 2003;21:821–48.PubMedCrossRefGoogle Scholar
  416. 416.
    Mancia G, Facchetti R, Bombelli M, Grassi G, Sega R. Long-term risk of mortality associated with selective and combined elevation in office, home, and ambulatory blood pressure. Hypertension. 2006;47:846–53.PubMedCrossRefGoogle Scholar
  417. 417.
    Verberk W, Kroon AA, de Leeuw PW. Masked hypertension and white-coat hypertension prognosis. J Am Coll Cardiol. 2006;47:2127. author reply 2127–2128.PubMedCrossRefGoogle Scholar
  418. 418.
    Havranek EP, Froshaug DB, Emserman CD, Hanratty R, Krantz MJ, Masoudi FA, et al. Left ventricular hypertrophy and cardiovascular mortality by race and ethnicity. Am J Med. 2008;121:870–5.PubMedCrossRefGoogle Scholar
  419. 419.
    Okin PM, Devereux RB, Jern S, Kjeldsen SE, Julius S, Nieminen MS, et al. Regression of electrocardiographic left ventricular hypertrophy during antihypertensive treatment and the prediction of major cardiovascular events. JAMA. 2004;292:2343–9.PubMedCrossRefGoogle Scholar
  420. 420.
    Taylor HA, Penman AD, Han H, Dele-Michael A, Skelton TN, Fox ER, et al. Left ventricular architecture and survival in African-Americans free of coronary heart disease (from the Atherosclerosis Risk in Communities [ARIC] study). Am J Cardiol. 2007;99:1413–20.PubMedCrossRefGoogle Scholar
  421. 421.
    Touboul PJ, Hennerici MG, Meairs S, Adams H, Amarenco P, Desvarieux M, et al. Mannheim intima-media thickness consensus. Cerebrovasc Dis. 2004;18:346–9.PubMedCrossRefGoogle Scholar
  422. 422.
    Feringa HH, Bax JJ, van Waning VH, Boersma E, Elhendy A, Schouten O, et al. The long-term prognostic value of the resting and postexercise ankle–brachial index. Arch Intern Med. 2006;166:529–35.PubMedCrossRefGoogle Scholar
  423. 423.
    Willum-Hansen T, Staessen JA, Torp-Pedersen C, Rasmussen S, Thijs L, Ibsen H, et al. Prognostic value of aortic pulse wave velocity as index of arterial stiffness in the general population. Circulation. 2006;113:664–70.PubMedCrossRefGoogle Scholar
  424. 424.
    Sarnak MJ, Levey AS, Schoolwerth AC, Coresh J, Culleton B, Hamm LL, et al. Kidney disease as a risk factor for development of cardiovascular disease: a statement from the American Heart Association Councils on Kidney in Cardiovascular Disease, High Blood Pressure Research, Clinical Cardiology, and Epidemiology and Prevention. Circulation. 2003;108:2154–69.PubMedCrossRefGoogle Scholar
  425. 425.
    Groppelli A, Giorgi DM, Omboni S, Parati G, Mancia G. Persistent blood pressure increase induced by heavy smoking. J Hypertens. 1992;10:495–9.PubMedCrossRefGoogle Scholar
  426. 426.
    Holman RR, Paul SK, Bethel MA, Neil HA, Matthews DR. Long-term follow-up after tight control of blood pressure in type 2 diabetes. N Engl J Med. 2008;359:1565–76.PubMedCrossRefGoogle Scholar
  427. 427.
    Gradman AH, Schmieder RE, Lins RL, Nussberger J, Chiang Y, Bedigian MP. Aliskiren, a novel orally effective renin inhibitor provides dose-dependent antihypertensive efficacy placebo-like tolerability in hypertensive patients. Circulation. 2005;111:1012–8.PubMedCrossRefGoogle Scholar
  428. 428.
    Wald DS, Law M, Morris JK, Bestwick JP, Wald NJ. Combination therapy versus monotherapy in reducing blood pressure: meta-analysis on 11,000 participants from 42 trials. Am J Med. 2009;122:290–300.PubMedCrossRefGoogle Scholar
  429. 429.
    Dahlof B, Sever PS, Poulter NR, Wedel H, Beevers DG, Caulfield M, et al. Prevention of cardiovascular events with an antihypertensive regimen of amlodipine adding perindopril as required versus atenolol adding bendroflumethiazide as required, in the Anglo-Scandinavian Cardiac Outcomes Trial-Blood Pressure Lowering Arm (ASCOT-BPLA): a multicentre randomised controlled trial. Lancet. 2005;366:895–906.PubMedCrossRefGoogle Scholar
  430. 430.
    Jamerson K, Weber MA, Bakris GL, Dahlof B, Pitt B, Shi V, et al. Benazepril plus amlodipine or hydrochlorothiazide for hypertension in high-risk patients. N Engl J Med. 2008;359:2417–28.PubMedCrossRefGoogle Scholar
  431. 431.
    Yusuf S, Teo KK, Pogue J, Dyal L, Copland I, Schumacher H, et al. Telmisartan, ramipril, or both in patients at high risk for vascular events. N Engl J Med. 2008;358:1547–59.PubMedCrossRefGoogle Scholar
  432. 432.
    Mancia G, Laurent S, Agabiti-Rosei E, Ambrosioni E, Burnier M, Caulfield MJ, et al. Reappraisal of European guidelines on hypertension management: a European Society of Hypertension Task Force document. J Hypertens. 2009;27:2121–58.PubMedCrossRefGoogle Scholar
  433. 433.
    Beckett NS, Peters R, Fletcher AE, Staessen JA, Liu L, Dumitrascu D, et al. Treatment of hypertension in patients 80 years of age or older. N Engl J Med. 2008;358:1887–98.PubMedCrossRefGoogle Scholar
  434. 434.
    UK Prospective Diabetes Study (UKPDS) Group. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). Lancet. 1998;352:837–53.CrossRefGoogle Scholar
  435. 435.
    Patel A, MacMahon S, Chalmers J, Neal B, Billot L, Woodward M, et al. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. N Engl J Med. 2008;358:2560–72.PubMedCrossRefGoogle Scholar
  436. 436.
    Collins R, Armitage J, Parish S, Sleigh P, Peto R. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5963 people with diabetes: a randomised placebocontrolled trial. Lancet. 2003;361:2005–16.PubMedCrossRefGoogle Scholar
  437. 437.
    Heidenreich PA, Trogdon JG, Khavjou OA, Butler J, Dracup K, Ezekowitz MD, et al. Forecasting the future of cardiovascular disease in the United States: a policy statement from the American Heart Association. Circulation. 2011;123:933–44.PubMedCrossRefGoogle Scholar
  438. 438.
    Duckworth W, Abraira C, Moritz T, Reda D, Emanuele N, Reaven PD, et al. Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360:129–39.PubMedCrossRefGoogle Scholar
  439. 439.
    UK Prospective Diabetes Study Group. Effect of intensive blood-glucose control with metformin on complications in overweight patients with type 2 diabetes (UKPDS 34). Lancet. 1998;352:854–65.CrossRefGoogle Scholar
  440. 440.
    Hansson L, Zanchetti A, Carruthers SG, Dahlof B, Elmfeldt D, Julius S, et al. Effects of intensive blood-pressure lowering and low-dose aspirin in patients with hypertension: principal results of the Hypertension Optimal Treatment (HOT) randomised trial. HOT Study Group. Lancet. 1998;351:1755–62.PubMedCrossRefGoogle Scholar
  441. 441.
    UK Prospective Diabetes Study Group. Tight blood pressure control and risk of macrovascular and microvascular complications in type 2 diabetes: UKPDS 38. UK Prospective Diabetes Study Group. BMJ. 1998;317:703–13.CrossRefGoogle Scholar
  442. 442.
    Shepherd J, Barter P, Carmena R, Deedwania P, Fruchart JC, Haffner S, et al. Effect of lowering LDL cholesterol substantially below currently recommended levels in patients with coronary heart disease and diabetes: the Treating to New Targets (TNT) study. Diabetes Care. 2006;29:1220–6.PubMedCrossRefGoogle Scholar
  443. 443.
    De Berardis G, Sacco M, Strippoli GF, Pellegrini F, Graziano G, Tognoni G, et al. Aspirin for primary prevention of cardiovascular events in people with diabetes: meta-analysis of randomised controlled trials. BMJ. 2009;339:b4531.PubMedCrossRefGoogle Scholar
  444. 444.
    Holman RR, Paul SK, Bethel MA, Matthews DR, Neil HA. 10-year follow-up of intensive glucose control in type 2 diabetes. N Engl J Med. 2008;359:1577–89.PubMedCrossRefGoogle Scholar
  445. 445.
    Nathan DM, Cleary PA, Backlund JY, Genuth SM, Lachin JM, Orchard TJ, et al. Intensive diabetes treatment and cardiovascular disease in patients with type 1 diabetes. N Engl J Med. 2005;353:2643–53.PubMedCrossRefGoogle Scholar
  446. 446.
    Gerstein HC, Miller ME, Byington RP, Goff Jr DC, Bigger JT, Buse JB, et al. Effects of intensive glucose lowering in type 2 diabetes. N Engl J Med. 2008;358:2545–59.PubMedCrossRefGoogle Scholar
  447. 447.
    Ray KK, Seshasai SR, Wijesuriya S, Sivakumaran R, Nethercott S, Preiss D, et al. Effect of intensive control of glucose on cardiovascular outcomes and death in patients with diabetes mellitus: a meta-analysis of randomised controlled trials. Lancet. 2009;373:1765–72.PubMedCrossRefGoogle Scholar
  448. 448.
    Dormandy JA, Charbonnel B, Eckland DJ, Erdmann E, Massi-Benedetti M, Moules IK, et al. Secondary prevention of macrovascular events in patients with type 2 diabetes in the PROactive Study (PROspective pioglitAzone Clinical Trial In macro-Vascular Events): a randomised controlled trial. Lancet. 2005;366:1279–89.PubMedCrossRefGoogle Scholar
  449. 449.
    Turnbull FM, Abraira C, Anderson RJ, Byington RP, Chalmers JP, Duckworth WC, et al. Intensive glucose control and macrovascular outcomes in type 2 diabetes. Diabetologia. 2009;52:2288–98.PubMedCrossRefGoogle Scholar
  450. 450.
    Kelly TN, Bazzano LA, Fonseca VA, Thethi TK, Reynolds K, He J. Systematic review: glucose control and cardiovascular disease in type 2 diabetes. Ann Intern Med. 2009;151:394–403.PubMedGoogle Scholar
  451. 451.
    Cushman WC, Evans GW, Byington RP, Goff Jr DC, Grimm Jr RH, Cutler JA, et al. Effects of intensive blood-pressure control in type 2 diabetes mellitus. N Engl J Med. 2010;362:1575–85.PubMedCrossRefGoogle Scholar
  452. 452.
    Kearney PM, Blackwell L, Collins R, Keech A, Simes J, Peto R, et al. Efficacy of cholesterol-lowering therapy in 18,686 people with diabetes in 14 randomised trials of statins: a meta-analysis. Lancet. 2008;371:117–25.PubMedCrossRefGoogle Scholar
  453. 453.
    Collaborative overview of randomised trials of antiplatelet therapy—I: prevention of death, myocardial infarction, and stroke by prolonged antiplatelet therapy in various categories of patients. Antiplatelet Trialists’ Collaboration. BMJ 1994;308:81–106.Google Scholar
  454. 454.
    Antithrombotic Trialists’ Collaboration. Collaborative meta-analysis of randomised trials of antiplatelet therapy for prevention of death, myocardial infarction, and stroke in high risk patients. BMJ. 2002;324:71–86.CrossRefGoogle Scholar
  455. 455.
    Gaede P, Vedel P, Larsen N, Jensen GV, Parving HH, Pedersen O. Multifactorial intervention and cardiovascular disease in patients with type 2 diabetes. N Engl J Med. 2003;348:383–93.PubMedCrossRefGoogle Scholar
  456. 456.
    Gaede P, Lund-Andersen H, Parving HH, Pedersen O. Effect of a multifactorial intervention on mortality in type 2 diabetes. N Engl J Med. 2008;358:580–91.PubMedCrossRefGoogle Scholar
  457. 457.
    Neaton JD, Blackburn H, Jacobs D, Kuller L, Lee DJ, Sherwin R, et al. Serum cholesterol level mortality findings for men screened in the Multiple Risk Factor Intervention Trial. Multiple Risk Factor Intervention Trial Research Group. Arch Intern Med. 1992;152:1490–500.PubMedCrossRefGoogle Scholar
  458. 458.
    Smith GD, Shipley MJ, Marmot MG, Rose G. Plasma cholesterol concentration, mortality. The Whitehall Study. JAMA. 1992;267:70–6.PubMedCrossRefGoogle Scholar
  459. 459.
    Baigent C, Blackwell L, Emberson J, Holland LE, Reith C, Bhala N, et al. Efficacy and safety of more intensive lowering of LDL cholesterol: a meta-analysis of data from 170,000 participants in 26 randomised trials. Lancet. 2010;376:1670–81.PubMedCrossRefGoogle Scholar
  460. 460.
    Brugts JJ, Yetgin T, Hoeks SE, Gotto AM, Shepherd J, Westendorp RG, et al. The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials. BMJ. 2009;338:b2376.PubMedCrossRefGoogle Scholar
  461. 461.
    Mills EJ, Rachlis B, Wu P, Devereaux PJ, Arora P, Perri D. Primary prevention of cardiovascular mortality and events with statin treatments: a network meta-analysis involving more than 65,000 patients. J Am Coll Cardiol. 2008;52:1769–81.PubMedCrossRefGoogle Scholar
  462. 462.
    Pedersen TR, Faergeman O, Kastelein JJ, Olsson AG, Tikkanen MJ, Holme I, et al. High-dose atorvastatin vs usual-dose simvastatin for secondary prevention after myocardial infarction: the IDEAL study: a randomized controlled trial. JAMA. 2005;294:2437–45.PubMedCrossRefGoogle Scholar
  463. 463.
    LaRosa JC, Grundy SM, Waters DD, Shear C, Barter P, Fruchart JC, et al. Intensive lipid lowering with atorvastatin in patients with stable coronary disease. N Engl J Med. 2005;352:1425–35.PubMedCrossRefGoogle Scholar
  464. 464.
    Neil A, Cooper J, Betteridge J, Capps N, McDowell I, Durrington P, et al. Reductions in all-cause, cancer, and coronary mortality in statin-treated patients with heterozygous familial hypercholesterolaemia: a prospective registry study. Eur Heart J. 2008;29:2625–33.PubMedCrossRefGoogle Scholar
  465. 465.
    Jensen J, Blankenhorn DH, Kornerup V. Coronary disease in familial hypercholesterolemia. Circulation. 1967;36:77–82.PubMedCrossRefGoogle Scholar
  466. 466.
    Schwartz GG, Olsson AG, Ezekowitz MD, Ganz P, Oliver MF, Waters D, et al. Effects of atorvastatin on early recurrent ischemic events in acute coronary syndromes: the MIRACL study: a randomized controlled trial. JAMA. 2001;285:1711–8.PubMedCrossRefGoogle Scholar
  467. 467.
    Ray KK, Cannon CP, McCabe CH, Cairns R, Tonkin AM, Sacks FM, et al. Early and late benefits of high-dose atorvastatin in patients with acute coronary syndromes: results from the PROVE IT-TIMI 22 trial. J Am Coll Cardiol. 2005;46:1405–10.PubMedCrossRefGoogle Scholar
  468. 468.
    de Lemos JA, Blazing MA, Wiviott SD, Lewis EF, Fox KA, White HD, et al. Early intensive vs a delayed conservative simvastatin strategy in patients with acute coronary syndromes: phase Z of the A to Z trial. JAMA. 2004;292:1307–16.PubMedCrossRefGoogle Scholar
  469. 469.
    Amarenco P, Labreuche J. Lipid management in the prevention of stroke: review and updated meta-analysis of statins for stroke prevention. Lancet Neurol. 2009;8:453–63.PubMedCrossRefGoogle Scholar
  470. 470.
    Byington RP, Davis BR, Plehn JF, White HD, Baker J, Cobbe SM, et al. Reduction of stroke events with pravastatin: the Prospective Pravastatin Pooling (PPP) Project. Circulation. 2001;103:387–92.PubMedCrossRefGoogle Scholar
  471. 471.
    Fowkes FG, Murray GD, Butcher I, Heald CL, Lee RJ, Chambless LE, et al. Ankle brachial index combined with Framingham Risk Score to predict cardiovascular events and mortality: a meta-analysis. JAMA. 2008;300:197–208.PubMedCrossRefGoogle Scholar
  472. 472.
    Aung PP, Maxwell HG, Jepson RG, Price JF, Leng GC. Lipid-lowering for peripheral arterial disease of the lower limb. Cochrane Database Syst Rev. 2007;4:CD000123.PubMedGoogle Scholar
  473. 473.
    Navaneethan SD, Perkovic V, Johnson DW, Nigwekar SU, Craig JC, Strippoli GF. HMG CoA reductase inhibitors (statins) for kidney transplant recipients. Cochrane Database Syst Rev. 2009;2:CD005019.PubMedGoogle Scholar
  474. 474.
    Sandhu S, Wiebe N, Fried LF, Tonelli M. Statins for improving renal outcomes: a meta-analysis. J Am Soc Nephrol. 2006;17:2006–16.PubMedCrossRefGoogle Scholar
  475. 475.
    Thompson A, Danesh J. Associations between apolipoprotein B, apolipoprotein AI, the apolipoprotein B/AI ratio and coronary heart disease: a literature-based meta-analysis of prospective studies. J Intern Med. 2006;259:481–92.PubMedCrossRefGoogle Scholar
  476. 476.
    McQueen MJ, Hawken S, Wang X, Ounpuu S, Sniderman A, Probstfield J, et al. Lipids, lipoproteins, and apolipoproteins as risk markers of myocardial infarction in 52 countries (the INTERHEART study): a case–control study. Lancet. 2008;372:224–33.PubMedCrossRefGoogle Scholar
  477. 477.
    Nordestgaard BG, Benn M, Schnohr P, Tybjaerg-Hansen A. Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women. JAMA. 2007;298:299–308.PubMedCrossRefGoogle Scholar
  478. 478.
    Chapman MJ, Ginsberg HN, Amarenco P, Andreotti F, Boren J, Catapano AL, et al. Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management. Eur Heart J. 2011;32:1345–61.PubMedCrossRefGoogle Scholar
  479. 479.
    Fruchart JC, Sacks F, Hermans MP, Assmann G, Brown WV, Ceska R, et al. The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in patients with dyslipidemia. Am J Cardiol. 2008;102:p1K–p34K.CrossRefGoogle Scholar
  480. 480.
    Nordestgaard BG, Chapman MJ, Ray K, Boren J, Andreotti F, Watts GF, et al. Lipoprotein(a) as a cardiovascular risk factor: current status. Eur Heart J. 2010;31:2844–53.PubMedCrossRefGoogle Scholar
  481. 481.
    Yusuf S, Hawken S, Ounpuu S, Dans T, Avezum A, Lanas F, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): case–control study. Lancet. 2004;364:937–52.PubMedCrossRefGoogle Scholar
  482. 482.
    Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18:499–502.PubMedGoogle Scholar
  483. 483.
    Robinson JG, Wang S, Smith BJ, Jacobson TA. Meta-analysis of the relationship between non-high-density lipoprotein cholesterol reduction and coronary heart disease risk. J Am Coll Cardiol. 2009;53:316–22.PubMedCrossRefGoogle Scholar
  484. 484.
    Reiner Z. How to improve cardiovascular diseases prevention in Europe? Nutr Metab Cardiovasc Dis. 2009;19:451–4.PubMedCrossRefGoogle Scholar
  485. 485.
    Preis SR, Hwang SJ, Coady S, Pencina MJ, D’Agostino Sr RB, Savage PJ, et al. Trends in all-cause and cardiovascular disease mortality among women and men with and without diabetes mellitus in the Framingham Heart Study, 1950 to 2005. Circulation. 2009;119:1728–35.PubMedCrossRefGoogle Scholar
  486. 486.
    Tendera M, Aboyans V, Bartelink ML, Baumgartner I, Clement D, Collet JP, et al. ESC Guidelines on the diagnosis and treatment of peripheral artery diseases: document covering atherosclerotic disease of extracranial carotid and vertebral, mesenteric, renal, upper and lower extremity arteries: The Task Force on the Diagnosis and Treatment of Peripheral Artery Diseases of the European Society of Cardiology (ESC). Eur Heart J. 2011;32:2851–906.PubMedCrossRefGoogle Scholar
  487. 487.
    Schouten O, Boersma E, Hoeks SE, Benner R, van Urk H, van Sambeek MR, et al. Fluvastatin and perioperative events in patients undergoing vascular surgery. N Engl J Med. 2009;361:980–9.PubMedCrossRefGoogle Scholar
  488. 488.
    Tedeschi-Reiner E, Strozzi M, Skoric B, Reiner Z. Relation of atherosclerotic changes in retinal arteries to the extent of coronary artery disease. Am J Cardiol. 2005;96:1107–9.PubMedCrossRefGoogle Scholar
  489. 489.
    Hebert PR, Gaziano JM, Chan KS, Hennekens CH. Cholesterol lowering with statin drugs, risk of stroke, and total mortality. An overview of randomized trials. JAMA. 1997;278:313–21.PubMedCrossRefGoogle Scholar
  490. 490.
    Tanne D, Koren-Morag N, Graff E, Goldbourt U. Blood lipids and first-ever ischemic stroke/transient ischemic attack in the Bezafibrate Infarction Prevention (BIP) Registry: high triglycerides constitute an independent risk factor. Circulation. 2001;104:2892–7.PubMedCrossRefGoogle Scholar
  491. 491.
    Sacco RL, Benson RT, Kargman DE, Boden-Albala B, Tuck C, Lin IF, et al. High-density lipoprotein cholesterol and ischemic stroke in the elderly: the Northern Manhattan Stroke Study. JAMA. 2001;285:2729–35.PubMedCrossRefGoogle Scholar
  492. 492.
    Kwan BC, Kronenberg F, Beddhu S, Cheung AK. Lipoprotein metabolism and lipid management in chronic kidney disease. J Am Soc Nephrol. 2007;18:1246–61.PubMedCrossRefGoogle Scholar
  493. 493.
    Fellstrom BC, Jardine AG, Schmieder RE, Holdaas H, Bannister K, Beutler J, et al. Rosuvastatin and cardiovascular events in patients undergoing hemodialysis. N Engl J Med. 2009;360:1395–407.PubMedCrossRefGoogle Scholar
  494. 494.
    Le VV, Racine N, Pelletier GB, Carrier M, Cossette M, White M. Impact of ezetimibe on cholesterol subfractions in dyslipidemic cardiac transplant recipients receiving statin therapy. Clin Transplant. 2009;23:249–55.PubMedCrossRefGoogle Scholar
  495. 495.
    Nissen SE, Nicholls SJ, Sipahi I, Libby P, Raichlen JS, Ballantyne CM, et al. Effect of very high-intensity statin therapy on regression of coronary atherosclerosis: the ASTEROID trial. JAMA. 2006;295:1556–65.PubMedCrossRefGoogle Scholar
  496. 496.
    Reiner Z, Galic M, Hanzevacki M, Tedeschi-Reiner E. Concomitant use of statins and cytochrome P 450 inhibitors in Croatia. Lijec Vjesn. 2005;127:65–8.PubMedGoogle Scholar
  497. 497.
    Waters DD, Ho JE, DeMicco DA, Breazna A, Arsenault BJ, Wun CC, et al. Predictors of new-onset diabetes in patients treated with atorvastatin: results from 3 large randomized clinical trials. J Am Coll Cardiol. 2011;57:1535–45.PubMedCrossRefGoogle Scholar
  498. 498.
    Culver AL, Ockene IS, Balasubramanian R, Olendzki BC, Sepavich DM, Wactawski-Wende J, et al. Statin use and risk of diabetes mellitus in postmenopausal women in the Women’s Health Initiative. Arch Intern Med. 2012;172:144–52.PubMedCrossRefGoogle Scholar
  499. 499.
    Fruchart JC, Sacks FM, Hermans MP, Assmann G, Brown WV, Ceska R, et al. The Residual Risk Reduction Initiative: a call to action to reduce residual vascular risk in dyslipidaemic patient. Diab Vasc Dis Res. 2008;5:319–35.PubMedCrossRefGoogle Scholar
  500. 500.
    Reiner Ž. Combined therapy in the treatment of dyslipidemia. Fundam Clin Pharmacol. 2010;24:19–28.PubMedCrossRefGoogle Scholar
  501. 501.
    Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S, Neumann FJ, Ardissino D, De Servi S, Murphy SA, Riesmeyer J, Weerakkody G, Gibson CM, Antman EM. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med 2007;357:2001–2015.Google Scholar
  502. 502.
    Baigent C, Blackwell L, Collins R, Emberson J, Godwin J, Peto R, et al. Aspirin in the primary and secondary prevention of vascular disease: collaborative meta-analysis of individual participant data from randomised trials. Lancet. 2009;373:1849–60.PubMedCrossRefGoogle Scholar
  503. 503.
    Bhatt DL, Fox KA, Hacke W, Berger PB, Black HR, Boden WE, et al. Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events. N Engl J Med. 2006;354:1706–17.PubMedCrossRefGoogle Scholar
  504. 504.
    Chen ZM, Sandercock P, Pan HC, Counsell C, Collins R, Liu LS, et al. Indications for early aspirin use in acute ischemic stroke: a combined analysis of 40000 randomized patients from the Chinese acute stroketrial the international stroke trial. On behalf of the CAST and IST collaborative groups. Stroke. 2000;31:1240–9.PubMedCrossRefGoogle Scholar
  505. 505.
    Chen ZM, Jiang LX, Chen YP, Xie JX, Pan HC, Peto R, et al. Addition of clopidogrel to aspirin in 45,852 patients with acute myocardial infarction: randomized placebo-controlled trial. Lancet. 2005;366:1607–21.PubMedCrossRefGoogle Scholar
  506. 506.
    Investigators TCT. Effects of clopidogrel in addition to aspirin in patients with acute coronary syndromes without ST-segment elevation. N Engl J Med. 2001;345:494–502.CrossRefGoogle Scholar
  507. 507.
    Wiviott SD, Braunwald E, McCabe CH, Montalescot G, Ruzyllo W, Gottlieb S, et al. Prasugrel versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2007;357:2001–15.PubMedCrossRefGoogle Scholar
  508. 508.
    Gurbel PA, Bliden KP, Butler K, Tantry US, Gesheff T, Wei C, et al. Randomized double-blind assessment of the ONSET and OFFSET of the antiplatelet effects of ticagrelor versus clopidogrel in patients with stable coronary artery disease: the ONSET/OFFSET study. Circulation. 2009;120:2577–85.PubMedCrossRefGoogle Scholar
  509. 509.
    Wallentin L, Becker RC, Budaj A, Cannon CP, Emanuelsson H, Held C, et al. Ticagrelor versus clopidogrel in patients with acute coronary syndromes. N Engl J Med. 2009;361:1045–57.PubMedCrossRefGoogle Scholar
  510. 510.
    Sacco RL, Diener HC, Yusuf S, Cotton D, Ounpuu S, Lawton WA, et al. Aspirin and extended-release dipyridamole versus clopidogrel for recurrent stroke. N Engl J Med. 2008;359:1238–51.PubMedCrossRefGoogle Scholar
  511. 511.
    A randomised, blinded, trial of clopidogrel versus aspirin in patients at risk of ischaemic events (CAPRIE). CAPRIE Steering Committee. Lancet 1996;348:1329–39.Google Scholar
  512. 512.
    Diener HC, Bogousslavsky J, Brass LM, Cimminiello C, Csiba L, Kaste M, et al. Aspirin and clopidogrel compared with clopidogrel alone after recent ischaemic stroke or transient ischaemic attack in high-risk patients (MATCH): randomised, double-blind, placebo-controlled trial. Lancet. 2004;364:331–7.PubMedCrossRefGoogle Scholar
  513. 513.
    De Schryver EL, Algra A, van Gijn J. Dipyridamole for preventing stroke and other vascular events in patients with vascular disease. Cochrane Database Syst Rev. 2007;3:CD001820.PubMedGoogle Scholar
  514. 514.
    Mohr JP, Thompson JL, Lazar RM, Levin B, Sacco RL, Furie KL, et al. A comparison of warfarin and aspirin for the prevention of recurrent ischemic stroke. N Engl J Med. 2001;345:1444–51.PubMedCrossRefGoogle Scholar
  515. 515.
    Liu M, Counsell C, Sandercock P. Anticoagulants for preventing recurrence following ischaemic stroke or transient ischaemic attack. Cochrane Database Syst Rev. 2000;2:CD000248.PubMedGoogle Scholar
  516. 516.
    Singer DE, Albers GW, Dalen JE, Fang MC, Go AS, Halperin JL, et al. Antithrombotic therapy in atrial fibrillation: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition). Chest. 2008;133:p546S–92S.CrossRefGoogle Scholar
  517. 517.
    Camm AJ, Kirchhof P, Lip GY, Schotten U, Savelieva I, Ernst S, et al. Guidelines for the management of atrial fibrillation: the Task Force for the Management of Atrial Fibrillation of the European Society of Cardiology (ESC). Eur Heart J. 2010;31:2369–429.PubMedCrossRefGoogle Scholar
  518. 518.
    Ho PM, Bryson CL, Rumsfeld JS. Medication adherence: its importance in cardiovascular outcomes. Circulation. 2009;119:3028–35.PubMedCrossRefGoogle Scholar
  519. 519.
    Osterberg L, Blaschke T. Adherence to medication. N Engl J Med. 2005;353:487–97.PubMedCrossRefGoogle Scholar
  520. 520.
    Kripalani S, Yao X, Haynes RB. Interventions to enhance medication adherence in chronic medical conditions: a systematic review. Arch Intern Med. 2007;167:540–50.PubMedCrossRefGoogle Scholar
  521. 521.
    Doshi JA, Zhu J, Lee BY, Kimmel SE, Volpp KG. Impact of a prescription copayment increase on lipid-lowering medication adherence in veterans. Circulation. 2009;119:390–7.PubMedCrossRefGoogle Scholar
  522. 522.
    Gehi A, Haas D, Pipkin S, Whooley MA. Depression and medication adherence in outpatients with coronary heart disease: findings from the Heart and Soul Study. Arch Intern Med. 2005;165:2508–13.PubMedCrossRefGoogle Scholar
  523. 523.
    Tarn DM, Heritage J, Paterniti DA, Hays RD, Kravitz RL, Wenger NS. Physician communication when prescribing new medications. Arch Intern Med. 2006;166:1855–62.PubMedCrossRefGoogle Scholar
  524. 524.
    Simpson SH, Eurich DT, Majumdar SR, Padwal RS, Tsuyuki RT, Varney J, et al. A meta-analysis of the association between adherence to drug therapy and mortality. BMJ. 2006;333:15.PubMedCrossRefGoogle Scholar
  525. 525.
    Combination Pharmacotherapy and Public Health Research Working Group. Combination pharmacotherapy for cardiovascular disease. Ann Intern Med. 2005;143:593–9.Google Scholar
  526. 526.
    Sleight P, Pouleur H, Zannad F. Benefits, challenges, registerability of the polypill. Eur Heart J. 2006;27:1651–6.PubMedCrossRefGoogle Scholar
  527. 527.
    Yusuf S, Pais P, Afzal R, Xavier D, Teo K, Eikelboom J, et al. Effects of a polypill (Polycap) on risk factors in meddle-aged individuals without cardiovascular disease (TIPS): a phase II, double-blind, randomised trial. Lancet. 2009;373:1341–51.PubMedCrossRefGoogle Scholar
  528. 528.
    Weintraub WS, Daniels SR, Burke LE, Franklin BA, Goff Jr DC, Hayman LL, et al. Value of primordial and primary prevention for cardiovascular disease: a policy statement from the American Heart Association. Circulation. 2011;124:967–90.PubMedCrossRefGoogle Scholar
  529. 529.
    Brown JR, O’Connor GT. Coronary heart disease and prevention in the United States. N Engl J Med. 2010;362:2150–3.PubMedCrossRefGoogle Scholar
  530. 530.
    Berra K, Miller NH, Fair JM. Cardiovascular disease prevention and disease management: a critical role for nursing. J Cardiopulm Rehabil. 2006;26:197–206.PubMedCrossRefGoogle Scholar
  531. 531.
    Berra K, Fletcher BJ, Hayman LL, Miller NH. Global cardiovascular disease prevention: a call to action for nursing: the global burden of cardiovascular disease. J Cardiovasc Nurs. 2011;26:S1–2.PubMedCrossRefGoogle Scholar
  532. 532.
    Voogdt-Pruis HR, Beusmans GH, Gorgels AP, Kester AD, Van Ree JW. Effectiveness of nurse-delivered cardiovascular risk management in primary care: a randomised trial. Br JGen Pract. 2010;60:40–6.CrossRefGoogle Scholar
  533. 533.
    Campbell NC, Ritchie LD, Thain J, Deans HG, Rawles JM, Squair JL. Secondary prevention in coronary heart disease: a randomised trial of nurse led clinics in primary care. Heart. 1998;80:447–52.PubMedGoogle Scholar
  534. 534.
    Koelewijn-van Loon MS, van der Weijden T, Ronda G, van Steenkiste B, Winkens B, Elwyn G, et al. Improving lifestyle and risk perception through patient involvement in nurse-led cardiovascular risk management: a cluster-randomized controlled trial in primary care. Prev Med. 2010;50:35–44.PubMedCrossRefGoogle Scholar
  535. 535.
    Haskell WL, Alderman EL, Fair JM, Maron DJ, Mackey SF, Superko HR, et al. Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP). Circulation. 1994;89:975–90.PubMedCrossRefGoogle Scholar
  536. 536.
    Mancia G, Grassi G. Protection of patients with diabetes, with or without hypertension: implications of ADVANCE for clinical practice. J Hypertens Suppl. 2009;27:S19–23.PubMedCrossRefGoogle Scholar
  537. 537.
    Friberg L, Hammar N, Rosenqvist M. Stroke in paroxysmal atrial fibrillation: report from the Stockholm Cohort of Atrial Fibrillation. Eur Heart J. 2010;31:967–75.PubMedCrossRefGoogle Scholar
  538. 538.
    Zhao L, Kolm P, Borger MA, Zhang Z, Lewis C, Anderson G, et al. Comparison of recovery after mitral valve repair and replacement. J Thorac Cardiovasc Surg. 2007;133:1257–63.PubMedCrossRefGoogle Scholar
  539. 539.
    Ghandehari H, Kamal-Bahl S, Wong ND. Prevalence and extent of dyslipidemia and recommended lipid levels in US adults with and without cardiovascular comorbidities: the National Health and Nutrition Examination Survey 2003–2004. Am Heart J. 2008;156:112–9.PubMedCrossRefGoogle Scholar
  540. 540.
    Wood DA. Clinical reality of coronary prevention in Europe: a comparison of EUROPASPIRE I, II, and III surveys. Paper presented at: The 29th Annual Congress of the European Society of Cardiology. Vienna, Austria. 1–5 September, 2007.Google Scholar
  541. 541.
    Graham IM, Stewart M, Hertog MG. Factors impeding the implementation of cardiovascular prevention guidelines: findings from a survey conducted by the European Society of Cardiology. Eur J Cardiovasc Prev Rehabil. 2006;13:839–45.PubMedCrossRefGoogle Scholar
  542. 542.
    Persson M, Carlberg B, Tavelin B, Lindholm LH. Doctors’ estimation of cardiovascular risk and willingness to give drug treatment in hypertension: fair risk assessment but defensive treatment policy. J Hypertens. 2004;22:65–71.PubMedCrossRefGoogle Scholar
  543. 543.
    1999 World Health Organization–International Society of Hypertension Guidelines for the Management of Hypertension. Guidelines subcommittee. J Hypertens. 1999;17:151–83.Google Scholar
  544. 544.
    Eichler K, Zoller M, Tschudi P, Steurer J. Barriers to apply cardiovascular prediction rules in primary care: a postal survey. BMC Fam Pract. 2007;8:1.PubMedCrossRefGoogle Scholar
  545. 545.
    van Steenkiste B, van der Weijden T, Stoffers HE, Grol R. Barriers to implementing cardiovascular risk tables in routine general practice. Scand J Prim Health Care. 2004;22:32–7.PubMedCrossRefGoogle Scholar
  546. 546.
    van Steenkiste B, van der Weijden T, Timmermans D, Vaes J, Stoffers J, Grol R. Patients’ ideas, fears and expectations of their coronary risk: barriers for primary prevention. Patient Educ Couns. 2004;55:301–7.PubMedCrossRefGoogle Scholar
  547. 547.
    Marshall T. Estimating the value of information in strategies for identifying patients at high risk of cardiovascular disease. Inform Prim Care. 2006;14:85–92.PubMedGoogle Scholar
  548. 548.
    Hartz I, Njolstad I, Eggen AE. Does implementation of the European guidelines based on the SCORE model double the number of Norwegian adults who need cardiovascular drugs for primary prevention? The Tromso study 2001. Eur Heart J. 2005;26:2673–80.PubMedCrossRefGoogle Scholar
  549. 549.
    Hedback B, Perk J. 5-year results of a comprehensive rehabilitation programme after myocardial infarction. Eur Heart J. 1987;8:234–42.PubMedGoogle Scholar
  550. 550.
    Sinclair G, Kerr A. The Bold Promise Project: a system change in primary care to support cardiovascular risk screening. N Z Med J. 2006;119:U2312.PubMedGoogle Scholar
  551. 551.
    Wells S, Furness S, Rafter N, Horn E, Whittaker R, Stewart A, et al. Integrated electronic decision support increases cardiovascular disease risk assessment four fold in routine primary care practice. Eur J Cardiovasc Prev Rehabil. 2008;15:173–8.PubMedCrossRefGoogle Scholar
  552. 552.
    Redberg RF, Benjamin EJ, Bittner V, Braun LT, Goff Jr DC, Havas S, et al. AHA/ACCF [corrected] 2009 performance measures for primary prevention of cardiovascular disease in adults: a report of the American College of Cardiology Foundation/American Heart Association task force on performance measures (writing committee to develop performance measures for primary prevention of cardiovascular disease): developed in collaboration with the American Academy of Family Physicians; American Association of Cardiovascular and Pulmonary Rehabilitation; and Preventive Cardiovascular Nurses Association: endorsed by the American College of Preventive Medicine, American College of Sports Medicine, and Society for Women’s Health Research. Circulation. 2009;120:1296–336.PubMedCrossRefGoogle Scholar
  553. 553.
    Matchar DB, Jacobson A, Dolor R, Edson R, Uyeda L, Phibbs CS, et al. Effect of home testing of international normalized ratio on clinical events. N Engl J Med. 2010;363:1608–20.PubMedCrossRefGoogle Scholar
  554. 554.
    Folsom AR, Yatsuya H, Nettleton JA, Lutsey PL, Cushman M, Rosamond WD. Community prevalence of ideal cardiovascular health, by the American Heart Association definition, and relationship with cardiovascular disease incidence. J Am Coll Cardiol. 2011;57:1690–6.PubMedCrossRefGoogle Scholar
  555. 555.
    Bramlage P, Messer C, Bitterlich N, Pohlmann C, Cuneo A, Stammwitz E, et al. The effect of optimal medical therapy on 1-year mortality after acute myocardial infarction. Heart. 2010;96:604–9.PubMedCrossRefGoogle Scholar
  556. 556.
    Hiratzka LF, Eagle KA, Liang L, Fonarow GC, LaBresh KA, Peterson ED. Atherosclerosis secondary prevention performance measures after coronary bypass graft surgery compared with percutaneous catheter intervention and nonintervention patients in the Get With the Guidelines database. Circulation. 2007;116:I207–I1212.PubMedCrossRefGoogle Scholar
  557. 557.
    Hamm CW, Bassand JP, Agewall S, Bax J, Boersma E, Bueno H. ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment elevation of the European Society of Cardiology (ESC). Eur Heart J. 2011;32:2999–3054.PubMedCrossRefGoogle Scholar
  558. 558.
    Smith Jr SC, Blair SN, Bonow RO, Brass LM, Cerqueira MD, Dracup K, et al. AHA/ACC Scientific Statement: AHA/ACC guidelines for preventing heart attack and death in patients with atherosclerotic cardiovascular disease: 2001 update: a statement for healthcare professionals from the American Heart Association and the American College of Cardiology. Circulation. 2001;104:1577–9.PubMedCrossRefGoogle Scholar
  559. 559.
    Yam FK, Akers WS, Ferraris VA, Smith K, Ramaiah C, Camp P, et al. Interventions to improve guideline compliance following coronary artery bypass grafting. Surgery. 2006;140:541–7. discussion 547–552.PubMedCrossRefGoogle Scholar
  560. 560.
    Williams JB, Delong ER, Peterson ED, Dokholyan RS, Ou FS, Ferguson Jr TB. Secondary prevention after coronary artery bypass graft surgery: findings of a national randomized controlled trial and sustained society-led incorporation into practice. Circulation. 2011;123:39–45.PubMedCrossRefGoogle Scholar
  561. 561.
    Rauch B, Schiele R, Schneider S, Diller F, Victor N, Gohlke H, et al. OMEGA, a randomized, placebo-controlled trial to test the effect of highly purified omega-3 fatty acids on top of modern guideline-adjusted therapy after myocardial infarction. Circulation. 2010;122:2152–9.PubMedCrossRefGoogle Scholar
  562. 562.
    Jolliffe JA, Rees K, Taylor RS, Thompson D, Oldridge N, Ebrahim S. Exercise-based rehabilitation for coronary heart disease. Cochrane Database Syst Rev. 2001;1:CD001800.PubMedGoogle Scholar
  563. 563.
    Antman EM, Anbe DT, Armstrong PW, Bates ER, Green LA, Hand M, et al. ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction–executive summary. A report of the American College of Cardiology/ American Heart Association Task Force on Practice Guidelines (Writing Committee to revise the 1999 guidelines for the management of patients with acute myocardial infarction). J Am Coll Cardiol. 2004;44:671–719.PubMedCrossRefGoogle Scholar
  564. 564.
    Braunwald E, Antman EM, Beasley JW, Califf RM, Cheitlin MD, Hochman JS, et al. ACC/AHA 2002 guideline update for the management of patients with unstable angina and non-ST-segment elevation myocardial infarction—summary article: a report of the American College of Cardiology/American Heart Association task force on practice guidelines (Committee on the Management of Patients With Unstable Angina). J Am Coll Cardiol. 2002;40:1366–74.PubMedCrossRefGoogle Scholar
  565. 565.
    Giannuzzi P, Temporelli PL, Marchioli R, Maggioni AP, Balestroni G, Ceci V, et al. Global secondary prevention strategies to limit event recurrence after myocardial infarction: results of the GOSPEL study, a multicenter, randomized controlled trial from the Italian Cardiac Rehabilitation Network. Arch Intern Med. 2008;168:2194–204.PubMedCrossRefGoogle Scholar
  566. 566.
    Mosca L, Banka CL, Benjamin EJ, Berra K, Bushnell C, Dolor RJ, et al. Evidence-based guidelines for cardiovascular disease prevention in women: 2007 update. J Am Coll Cardiol. 2007;49:1230–50.PubMedCrossRefGoogle Scholar
  567. 567.
    European Parliament. Resolution on action to tackle cardiovascular disease. 2007. Procedure: 2007/2601(RSP). http://www.europarl.europa.eu/sides/getDoc.do?pubRef=−//EP//TEXT+TA+P6-TA-2007-0346+0+DOC+XML+V0//EN&language=EN
  568. 568.
    Hammill BG, Curtis LH, Schulman KA, Whellan DJ. Relationship between cardiac rehabilitation and long-term risks of death and myocardial infarction among elderly Medicare beneficiaries. Circulation. 2010;121:63–70.PubMedCrossRefGoogle Scholar

Copyright information

© International Society of Behavioral Medicine 2012

Authors and Affiliations

  • Joep Perk
    • 1
  • Guy De Backer
    • 2
  • Helmut Gohlke
    • 2
  • Ian Graham
    • 2
  • Željko Reiner
    • 3
  • W. M. Monique Verschuren
    • 2
  • Christian Albus
    • 4
  • Pascale Benlian
    • 2
  • Gudrun Boysen
    • 5
  • Renata Cifkova
    • 6
  • Christi Deaton
    • 2
  • Shah Ebrahim
    • 2
  • Miles Fisher
    • 7
  • Giuseppe Germano
    • 2
  • Richard Hobbs
    • 2
    • 8
  • Arno Hoes
    • 8
  • Sehnaz Karadeniz
    • 9
  • Alessandro Mezzani
    • 2
  • Eva Prescott
    • 2
  • Lars Ryden
    • 2
  • Martin Scherer
    • 8
  • Mikko Syvänne
    • 10
  • Wilma J. M. Scholte Op Reimer
    • 2
  • Christiaan Vrints
    • 2
  • David Wood
    • 2
  • Jose Luis Zamorano
    • 2
  • Faiez Zannad
    • 2
  • Developed with the special contribution of the European Association for Cardiovascular Prevention & Rehabilitation (EACPR)
  1. 1.School of Health and Caring SciencesLinnaeus UniversityKalmarSweden
  2. 2.European Society of Cardiology (ESC)Sophia AntipolisFrance
  3. 3.European Atherosclerosis Society (EAS)GöteborgSWEDEN
  4. 4.International Society of Behavioural Medicine (ISBM)UlmGermany
  5. 5.European Stroke Organisation (ESO)BaselSwitzerland
  6. 6.European Society of Hypertension (ESH)PragueCzech Republic
  7. 7.European Association for the Study of Diabetes (EASD)DüsseldorfGermany
  8. 8.European Society of General Practice/Family Medicine (ESGP/FM/WONCA)LubljanaSlovenia
  9. 9.International Diabetes Federation Europe (IDF-Europe)BrusselsBelgium
  10. 10.European Heart Network (EHN)BrusselsBelgium

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