Magnetic resonance spectroscopy in Leigh-MELAS overlap syndrome

  • Ara Ko
  • Young-Mock LeeEmail author
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Author contributions

YML conceptualized the study, coordinated and supervised data collection, and critically reviewed and revised the manuscript. AK wrote the paper, checked and studied literature about the disease. All authors approved the final manuscript as submitted and agree to be accountable for the content of the work.



Compliance with ethical standards

Ethical approval

This study was carried out in accordance with the recommendations of the Institutional Review Board of Gangnam Severance Hospital, Yonsei University College of Medicine with written informed consent from the patient.

Conflict of interest

No financial or nonfinancial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.


  1. 1.
    Finsterer J. Leigh and Leigh-like syndrome in children and adults. Pediatr Neurol. 2008;39:223–35.CrossRefGoogle Scholar
  2. 2.
    Ito H, Mori K, Kagami S. Neuroimaging of stroke-like episodes in MELAS. Brain Dev. 2011;33:283–8.CrossRefGoogle Scholar
  3. 3.
    Crimi M, Galbiati S, Moroni I, Bordoni A, Perini MP, Lamantea E, et al. A missense mutation in the mitochondrial ND5 gene associated with a Leigh-MELAS overlap syndrome. Neurology. 2003;60:1857–61.CrossRefGoogle Scholar

Copyright information

© Children's Hospital, Zhejiang University School of Medicine 2019

Authors and Affiliations

  1. 1.Department of Pediatrics, Pusan National University Children’s HospitalPusan National University School of MedicineYangsanKorea
  2. 2.Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanRepublic of Korea
  3. 3.Department of Pediatrics, Gangnam Severance HospitalYonsei University College of MedicineSeoulSouth Korea

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