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Progress in understanding youth-onset type 2 diabetes in the United States: recent lessons from clinical trials

  • Philip ZeitlerEmail author
Review Article
  • 21 Downloads

Abstract

Background

Due to the dramatic increase in the rates of childhood obesity and youth-onset type 2 diabetes (T2D) in the late 1990s in the United States, the US government, through the National Institute of Diabetes, Digestive Disease, and Kidney (NIDDK) and the Centers for Disease Control, funded a series of large studies and trials which, together, have formed the basis for much of what we currently understand about youth-onset T2D.

Data sources

The review focus on the recent results and implications of the treatment options for Type 2 Diabetes in Adolescents and Youth (TODAY) study and the Restoring Insulin Secretion (RISE) study.

Results and Conclusions

Both TODAY and RISE studies have provided critical insight into the unique aspects of the pathophysiology of youth-onset type 2 diabetes and also provided the evidence base for our current approach to the management of this disorder.

Keywords

Insulin resistance Insulin sensitivity Obesity Type 2 diabetes 

Notes

Funding

None.

Compliance with ethical standards

Conflict of interest

No financial or nonfinancial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

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Copyright information

© Children's Hospital, Zhejiang University School of Medicine 2019

Authors and Affiliations

  1. 1.Section of Endocrinology, Department of PediatricsChildren’s Hospital Colorado, University of Colorado Anschutz Medical CampusAuroraUSA

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