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Features distinguishing juvenile idiopathic arthritis among children with musculoskeletal complaints

  • Satita Jeamsripong
  • Sirirat CharuvanijEmail author
Original Article
  • 66 Downloads

Abstract

Background

Musculoskeletal (MSK) complaints in children vary, ranging from benign, self-limited conditions to serious disorders. Juvenile idiopathic arthritis (JIA) is the most common rheumatic disease, initially presenting with MSK complaints. Delayed diagnosis and appropriate treatment have an enormous impact on the long-term outcomes and the level of disability. This study aimed to identify the features distinguishing JIA among children presenting with MSK complaints and to describe the spectrum of diseases at a large, single, tertiary center.

Methods

A retrospective chart review was performed of patients evaluated by pediatric rheumatology consultation at the Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand, from July 2011 to June 2015.

Results

Of 531 patients, 285 (53.6%) had at least one MSK complaint. The mean age of the patients was 9.1 ± 4.1 years. Joint pain was the most common MSK complaint (86.3%), followed by limping (33%) and refusal to walk (19.6%). Joint swelling and limited range of motion were found in 146 (51.2%) and 115 (40.4%) patients, respectively. Seventy-three (25.6%) patients were diagnosed as JIA. The other common diagnoses included Henoch–Schönlein purpura (16.1%), reactive arthritis (14.2%), and systemic lupus erythematosus (13.7%). Morning stiffness  ≥ 15 minutes [odds ratio (OR) 8.217 (3.404–19.833)]; joint swelling on MSK examination [OR 3.505 (1.754–7.004)]; a duration of MSK complaints of more than 6 weeks [OR 2.071 (1.120–3.829)]; and limping [OR 1.973 (1.048–3.712)] were significantly associated with the ultimate diagnosis of JIA.

Conclusions

Morning stiffness ≥ 15 minutes is a strong predictor of JIA. Comprehensive history taking and an MSK examination will provide clues for making the ultimate diagnosis for children with MSK complaints.

Keywords

Joint pain Juvenile idiopathic arthritis Limping Morning stiffness Musculoskeletal 

Notes

Author contributions

SJ contributed to concept and design, acquisition of data, analysis and drafting the manuscript. SC contributed to concept and design, acquisition of data, analysis, interpretation of data, drafting and revising the manuscript and corresponding author. Both authors approved the final version of the manuscript.

Funding

None.

Compliance with ethical standards

Ethical approval

Research procedures were performed in accordance with the Declaration of Helsinki. Ethical approval for the study was obtained from Siriraj Institutional Review Board (Si 325/2016), Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok, Thailand.

Conflict of interest

No financial or nonfinancial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

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Copyright information

© Children's Hospital, Zhejiang University School of Medicine 2018

Authors and Affiliations

  1. 1.Department of Pediatrics, Faculty of Medicine, Siriraj HospitalMahidol UniversityBangkokThailand
  2. 2.Division of Rheumatology, Department of Pediatrics, Faculty of Medicine, Siriraj HospitalMahidol UniversityBangkokThailand

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