World Journal of Pediatrics

, Volume 14, Issue 4, pp 373–377 | Cite as

Assessment of cardiac function in infants with transposition of the great arteries after surgery: comparison of two methods

  • Fan Yang
  • Roberta Iacobelli
  • Jian-Ming Wang
  • Fiore Salvatore IorioEmail author
Original Article



Assessment of cardiac function is crucial in pediatric patients undergoing cardiovascular surgery, monitoring cardiac output and changing hemodynamic conditions during surgery accordingly is important to improve post-surgical outcome. We aimed to measure cardiac index (CI) and maximal rate of the increase of left ventricular pressure dp/dt(max) with the pressure recording analytic method (PRAM, MostCare®) and compared it with transthoracic echocardiographic cardiac index estimation in infants with transposition of the great arteries (TGA) undergoing surgical correction.


We enrolled 74 infants with TGA consecutively into this study. CI and dp/dt(max) were measured with PRAM and echocardiography at 0, 4, 8, 12, 24 and 48 h postoperatively. Blood brain natriuretic peptide (BNP) and blood lactate (Lac) were measured at baseline and after operation.


The median age at surgery was 13 days (range 1–25 days) with an average weight of 3.24 kg (range 2.31–4.17 kg). CI estimated by PRAM was 1.11 ± 0.12 L/min/m2 (range 0.69–1.36) and by Doppler echocardiography was 1.13 ± 0.13 L/min/m2 (range 0.76–1.40). dp/dt(max) estimated by PRAM was 1.31 ± 0.03 mmHg/s (range 1.23–1.43) and by Doppler echocardiography was 1.31 ± 0.04 L/min/m2 (range 1.25–1.47). CI (r = 0.817, < 0.001) and dp/dt(max) (r = 0.794, P < 0.001) measured by two methods were highly correlated with a linear relation. Blood BNP and lactate increased to the highest level at 8–12 h post-operatively.


In the early post-operative period, PRAM provides reliable estimates of cardiac index and dp/dt(max) value compared with echocardiographic measurements. PRAM through mostcare® is a reliable continuous monitoring method for peri-operative management in children with congenital heart disease.


Cardiac index Doppler echocardiography dp/dt(max) Pressure recording analytic method Transposition of the great arteries 



We thank everybody of this study group members. We also thank the physicians and nurses of HBCH and OPBG-units for their dedicated work and the patients and their families for their cooperation.

Author contributions

YF designed the study, collected cases, analyzed the data and wrote the paper. RI designed the study, wrote part of the paper and corrected the original paper. WJM and FSI contributed to offer the suitable cases and related equipments. All authors contributed to the critical revision and final approval of the manuscript.


No funding was secured for this study.

Compliance with ethical standards

Ethical approval

The study protocol was approved by Local Ethics Committee of Hebei Province Children’s Hospital.

Conflict of interest

No financial or nonfinancial benefits have been received or will be received from any party related directly or indirectly to the subject of this article.

Supplementary material

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Supplementary material 1 (TIFF 54703 kb)
12519_2018_178_MOESM2_ESM.docx (15 kb)
Supplementary material 2 (DOCX 15 kb)


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Copyright information

© Children's Hospital, Zhejiang University School of Medicine 2018

Authors and Affiliations

  1. 1.Cardiac Surgery DepartmentHebei Province Children’s HospitalShijiazhuangChina
  2. 2.Pediatric Cardiology Center of Ospedale Pediatrico Bambino GesùRomeItaly

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