World Journal of Pediatrics

, Volume 14, Issue 4, pp 410–411 | Cite as

Consecutive occurrence of benign epilepsy with centro-temporal spike and childhood absence epilepsy: true coexistence or atypical evolution?

  • Eun Hye LeeEmail author
  • Hoi Soo Yoon
Letter to the Editor

We read with great interest the recent review of benign epilepsy with centro-temporal spikes (BECTS) and childhood absence epilepsy (CAE) by Verrotti et al. [1]. BECTS and CAE are the most common epilepsy syndromes in childhood and share certain clinical features: similar age at onset, overall good prognosis, and genetic predisposition. Several studies have reported the coexistence of the two syndromes, and recently, Verrotti et al. analyzed 19 cases reported to have clinical features of CAE and BECTS. Among the total 19 cases, three cases had features of both syndromes contemporarily; three cases experienced absence seizures initially followed by BECTS; and the other 13 cases experienced BECTS at onset and had absence seizures later.

Here, we would like to consider the patients who presented with BECTS at onset and absence seizures later. Of the 13 patients, seven had typical or simple absence seizures and the other six had atypical absence seizures, atonic absences, absence seizure with fluttering, or eyelid myoclonia. According to inclusion and exclusion criteria for CAE proposed by Panayiotopoulos, these feature are not compatible with CAE [2]. Atypical absence seizures are differentiated from absence seizures in the frequency of spikes and wave discharges, refractoriness to medical therapy, and severely abnormal cognitive and neurodevelopmental outcome. Both typical and atypical absence epilepsy are thought to be generated by a rhythmogenic interplay between the cortex and the thalamus. However, it is hypothesized that atypical absence seizures engage different neuronal networks within the thalamo-cortical circuitry, as compared to typical absence seizures [3].

In some patients with BECTS, atypical evolution occur during the natural course or medical treatment. Atypical features at onset, such as frequent spikes or spike-wave discharges, or early age at onset, are considered risk factors for, and atypical evolution of, BECTS [4].

We suggest that some of the 13 patients with BECTS who later developed CAE might be examples of atypical evolution of BECTS rather than a true coincidence of two syndromes. Notably, three of 13 patients have experienced atypical absence seizures after the administration of antiepileptic drugs, which improved after drug withdrawal. Several authors have reported children with BECTS who developed CAE after admiration of antiepileptic drugs such as oxcarbazepine, phenobarbital, and lamotrigine [5, 6, 7]. This implies that the evolution to atypical BECTS was triggered by certain antiepileptic drugs in prone subjects. Similarly, five of the six patients in Dimova et al. were treated with carbamazepine, and they also suggested the possibility of aggravation of BECTS by the drugs [8].

Obviously, it is possible CAE and BECTS can simply co-exist. The three patients with contemporary onset of CAE and BECTS in this review are such cases, in whom neurocognitive function is normal and they have good responses to drugs. However, when CAE and BECTS occur consecutively in one patient, they should be distinguished from atypical evolution of BECTS. Especially in these cases, the effect of antiepileptic drug should be considered.


Author contributions

EHL and HSY revised the main conceptual ideas and proof outline. EHL wrote the manuscript in consultation with HSY.


This study was supported by the Basic Science Research Program of the National Research Foundation of Korea funded by the Ministry of Science, ICT and Future Planning (NRF- 2017R1C1B5076772).

Compliance with ethical standards

Ethical approval

Not needed.

Conflict of interest

The authors have no conflicts of interest relevant to this article.


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Copyright information

© Children's Hospital, Zhejiang University School of Medicine 2018

Authors and Affiliations

  1. 1.Department of Pediatrics, College of MedicineKyung Hee UniversitySeoulKorea

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