Does time taken to achieve jaundice-clearance influence survival of the native liver in post-Kasai biliary atresia?
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We reviewed the time taken for post-portoenterostomy (PE) biliary atresia (BA) patients to obtain jaundice-clearance (total bilirubin ≤ 1.2 mg/dL; JC) post-PE to determine if JC time (JCT) is prognostic for survival of the native liver (SNL).
The subjects were 66 BA patients treated with PE at our institute between 1989, the year when liver transplantation (LTx) became available in Japan, and 2014. JCT was used to create three groups (≤ 30 days: n = 14; 31–60 days: n = 31; ≥ 61 days: n = 21). Medical records were reviewed retrospectively to evaluate: age at onset of symptoms, duration of symptoms pre-PE, age and weight at PE, serum liver function tests, incidence of cholangitis, and micro-bile duct size at PE.
Age at onset of symptoms, age and weight at PE, duration of symptoms pre-PE, and micro-bile duct size were similar for all patients in all three groups. JCT and SNL appeared to correlate because preoperative total bilirubin (7.1, 9.6, 10.2 mg/dL; P < 0.05) was significantly lower in the JCT ≤ 30 days group (P < 0.05) while there was a significant decrease in SNL (P < 0.03) and a significant increase in LTx (P < 0.01) in the JCT ≥ 61 days group. All LTx subjects who achieved JC were found to have developed cholangitis within 3 months of PE.
During the follow-up of post-PE subjects, longer JCT and cholangitis occurrence within 3 months of PE would appear to be negative prognostic factors for SNL while preoperative total bilirubin would appear to be a positive prognostic factor for SNL.
KeywordsBiliary atresia Jaundice free Liver transplantation Native liver survival Portoenterostomy
HN contributed to the collection of data, and wrote the first version of the paper. HK contributed to the design, data analysis of this study, and wrote the first version of the paper. MO and HN contributed to the collection of data. GJL wrote the first version of the paper. AY contributed to the design and data analysis of this study. All authors approved the final version of the manuscript.
Compliance with ethical standards
This study was approved by the Juntendo University School of Medicine Institutional Review Board and complies with the Helsinki Declaration of 1975 (revised 1983).
Conflict of interest
The authors declare no conflict of interest.
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